Almotriptan

ChemicalBook > CAS DataBase List > Almotriptan

Product Name: Almotriptan
CAS No.: 154323-57-6
Chemical Name: Almotriptan
Synonyms: LAS-31416;Almotriptan;LAS-31416-d6;ALMOTRIPTAN-D6;AlMotriptan API;ALMOTRIPTAN(SUBJECTTOPATENETFREE);1-[[3-(2-dimethylaminoethyl)-5-indolyl]methanesulphonyl]pyrrolidine;N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-Indole-3-ethanamine;1-[[3-(2-dimethylaminoethyl)-5-indolyl]methanesulphonyl]pyrrolidine-d6;1-[[[2-(Dimethyl-amino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine
CBNumber: CB7716603
Molecular Formula: C17H25N3O2S
Formula Weight: 335.46
MOL File: 154323-57-6.mol

Less

Almotriptan Property

Boiling point:: 538.7±60.0 °C(Predicted)
Density: 1.27±0.1 g/cm3(Predicted)
pka: 16.92±0.30(Predicted)
CAS DataBase Reference: 154323-57-6(CAS DataBase Reference)

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P233Keep container tightly closed.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304IF INHALED:

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P340Remove victim to fresh air and keep at rest in a position comfortable for breathing.

P362Take off contaminated clothing and wash before reuse.

P403Store in a well-ventilated place.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0002140
Product name: Almotriptan for system suitability
Purity: CRS, European Pharmacopoeia (EP) Reference Standard
Packaging: Y0002140
Price: $156
Updated: 2024/03/01

Usbiological

Product number: A1358-90
Product name: Almotriptan
Packaging: 10mg
Price: $375
Updated: 2021/12/16

Matrix Scientific

Product number: 091207
Product name: N,N-Dimethyl-2-(5-((pyrrolidin-1-ylsulfonyl)-methyl)-1H-indol-3-yl)ethanamine
Purity: 95+%
Packaging: 1g
Price: $457
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: RDL0006650
Product name: ALMOTRIPTAN-D6
Purity: 95.00%
Packaging: 5MG
Price: $497.17
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb134783
Product name: Almotriptan
Purity: >99%
Packaging: 100mg
Price: $510
Updated: 2021/12/16

Less

Almotriptan Chemical Properties,Usage,Production

Description

Almotriptan was first marketed in Spain as a new medicine against acute attacks of migraine. It is the fifth agent belonging to the “triptan” class to be launched after sumatriptan, naratriptan, zolmitriptan and rizatriptan. This close structural analog of sumatriptan can be prepared in six steps from 4-nitrobenzylsulfonyl chloride with a Fischer indole synthesis as the key step. Almotriptan acts as a dual 5-HT_1D/1B agonist with a 35 to 51-fold selectivity versus 5-HT_1A and 5-HT₇ receptors respectively as well as having insignificant affinity for the most relevant nonserotonergic receptors (K1＞1μM). Its agonistic effect on 5-HT,n receptors of trigeminal sensory neurons turns off neurogenic inflammation by inhibiting the release of neuropeptides such as calcitonin gene-related peptide, neurokinin A and substance P. Concomitantly, its action on the 5-HT_1B receptors in meningeal arteries relieves the vasodilatation of these vessels associated with migraine attacks. Almotriptan causes selective concentration-dependent vasoconstriction of human meningeal and temporal arteries (with EC₅₀ of 0.03 and 0.7 μM) compared to basilar (EC₅₀ = 3.5 μM) and pulmonary arteries (EC₅₀＞10μM) or rabbit mesenteric and renal arteries (EC₅₀＞100 μM). Although it is predominantly cleared by the kidneys as unchanged drug (45%) or transformed into inactive metabolites by monoamine oxidase A (MAO-A) and CYP3A4 enzymes in the liver, almotriptan has the highest oral bioavailability (70%) of the triptans and has a half-life of 3.5 h. The therapeutic dose of 12.5 mg is well tolerated, shows a rapid onset of action (30 min) and low recurrence rate compared to sumatriptan.

Originator

Almirall Prodesfarma (Spain)

Uses

Serotonin 5HT1B /1D-receptor agonist

Definition

ChEBI: An indole compound having a 2-(dimethylamino)ethyl group at the 3-position and a (pyrrolidin-1-ylsulfonyl)methyl group at the 5-position.

Manufacturing Process

To a solution of previously dried 1-[[2-carboxy-3-(2-dimethylaminoethyl)-5- indolyl]methanesulphonyl]-pyrrolidine (1.6 g; 0.0442 moles) in anhydrous quinoline (75 ml) and under atmosphere of nitrogen, cuprous oxide (160 mg; 0.0011 moles) was added. The reaction mixture was heated to 190°C for 15 minutes, stirred to room temperature, poured into a mixture of 1 N hydrochloric acid (150 ml) and ethyl acetate (50 ml), shaken and decanted. The aqueous solution was washed several times with ethyl acetate, then solid sodium bicarbonate was added until pH = 7.8, and washed with n-hexane to eliminate the quinoline. The aqueous solution was made alkaline with solid potassium carbonate and extracted with ethyl acetate. The organic solution was dried (Na2SO4), the solvent removed under reduced pressure when a dark oil was obtained (1.3 g; yield 92%). This product was purified by column chromatography with silica gel and methylene chloride:ethanol:ammonium hydroxide (60:8:1) as eluent and a white foam (0.8 g) of 1-[[3-(2- dimethylaminoethyl)-5-indolyl]methanesulphonyl]-pyrrolidine was obtained. To a solution of the above product (0.8 g) in acetone (30 ml), a few drops of hydrogen chloride saturated dioxan solution, were added. The precipitated solid was collected by filtration, washed with acetone and dried to give 1-[(3- (2-(dimethylamino)ethyl)-5-indolyl)methanesulphonyl]-pyrrolidine hydrochloride (0.75 g). Melting point 218°-220°C.
In practice it is usually used as malate salt.

brand name

Almogran

Therapeutic Function

Migraine therapy

Clinical Use

5HT1 receptor agonist:
Acute relief of migraine

Drug interactions

Potentially hazardous interactions with other drugs
Antidepressants: increased risk of CNS toxicity with citalopram - avoid; possibly increased serotonergic effects with duloxetine or venlafaxine; increased serotonergic effects with St John’s wort - avoid.
Antifungals: concentration increased by ketoconazole (increased risk of toxicity).
Dapoxetine: possible increased risk of serotonergic effects - avoid for 2 weeks after stopping 5HT1 agonists.
Ergot alkaloids: increased risk of vasospasm - avoid.

Metabolism

The major biotransformation route is via monoamine oxidase (MAO-A) mediated oxidative deamination to the indole acetic metabolite. Cytochrome P450 (3A4 and 2D6 isozymes) and flavin mono-oxygenase are other enzymes involved in the metabolism of almotriptan. None of the metabolites are significantly active pharmacologically. More than 75% of a dose is eliminated in urine, and the remainder in faeces. Approximately, 50% of the urinary and faecal excretion is unchanged almotriptan.

Almotriptan Preparation Products And Raw materials

Raw materials

Preparation Products

Less

Almotriptan Suppliers

Canada 3 China 79 Europe 2 Germany 1 India 8 United Kingdom 1 United States 14 Global 108

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 18089
Advantage: 64

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7815
Advantage: 57

S.Z. PhyStandard Bio-Tech. Co., Ltd.

Tel: 0755-83725681-603
Fax: +86 755 28094224
Country: China
ProdList: 4505
Advantage: 50

Beijing Yisiyan Technology Research Center

Tel: 010-56645598 13366904824
Fax: 01062230033
Email: bjkaida@163.com
Country: China
ProdList: 1663
Advantage: 59

TargetMol Chemicals Inc.

Tel: 021-021-33632979 15002134094
Fax: 021-33632979
Email: marketing@targetmol.com
Country: China
ProdList: 7854
Advantage: 58

Shanghai Worldyang Chemical Co.,Ltd.

Tel: 021-021-56795766
Fax: +86-21-56795266
Email: sales@worldyachem.com
Country: China
ProdList: 9352
Advantage: 58

ChemStrong Scientific Co.,Ltd

Tel: 0755-0755-66853366 13670046396
Fax: 0755-28363542
Email: sales@chem-strong.com
Country: China
ProdList: 17994
Advantage: 56

Mashilabs (Shanghai) Co.,Ltd.

Tel: 19916721580
Fax: QQ：3154870176
Email: info@mashilabs.com
Country: China
ProdList: 4115
Advantage: 58

LETOPHARM LIMITED

Tel: +86-21-5821 5861
Fax: +86-21-5106 2861
Email: sales@letopharm.com
Country: China
ProdList: 2384
Advantage: 58

Chizhou Kailong Import and Export Trade Co., Ltd.

Tel
Fax: -
Email: xg01_gj@163.com
Country: China
ProdList: 9503
Advantage: 50

AN PharmaTech Co Ltd

Tel: 86(21)68097365
Fax: 86(21)33321566
Email: sales@anpharma.net
Country: China
ProdList: 4901
Advantage: 55

Artis Biotech Co. Ltd.

Tel: 19138486554 18582380095
Fax: 0575-89298961
Email: sales@artisbio.com
Country: China
ProdList: 2862
Advantage: 58

Shanghai Qiao Chemical Science Co., Ltd

Tel: 021-58892003
Email: info@qiaochem.com
Country: China
ProdList: 5881
Advantage: 65

parabiochem

Tel: 025-83453382-8005
Fax: 025-83453382
Email: sale@parabiochem.com
Country: China
ProdList: 9604
Advantage: 55

Shanghai Chaolan Chemical Technology Center

Tel: QQ:65489617 15618227136
Fax: 21-5161 9052
Email: info@SuperLan-chem.com
Country: China
ProdList: 9756
Advantage: 58

Shanghai SuperLan Chemcial Technique Centre

Tel: 021-2022843681 15618226720
Fax: +86-21-51601218
Email: chaolaichem@foxmail.com
Country: China
ProdList: 9038
Advantage: 58

Wellman Pharmaceutical Group Limited

Tel: 027-027-83778875 15807197853
Fax: 027-83991220
Email: 15807197853@163.com
Country: China
ProdList: 3979
Advantage: 58

Chemleader Biomedical Co., Limited.

Tel: 021-58180488
Fax: 021-58180499
Email: sales@MedChemLeader.com
Country: China
ProdList: 999
Advantage: 58

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28821
Advantage: 58

Wuhan FengyaoTonghui Chemical Products Co., Ltd.

Tel: 027-87466105 15377573527
Email: 2678564200@qq.com
Country: China
ProdList: 17997
Advantage: 58

Nanjing NingFan Pharm-Tech CO. LTD.

Tel: 17368696818
Country: China
ProdList: 1986
Advantage: 58

Shanghai He Huan Chemical Co., Ltd.

Tel: 021-60345187 13917602471
Fax: 021-60345187
Email: lzz841106@aliyun.com
Country: China
ProdList: 9908
Advantage: 58

Alchemist-pharm chemical Technology Co. Ltd.

Tel: 0371-67991738 13783628208
Fax: QQ 412703949
Email: carl@alchemist-pharm.com
Country: China
ProdList: 1877
Advantage: 58

Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.

Tel: 027-51831887 15337167856
Fax: 027-51837635 QQ1165326703
Email: hubeixinyuanshun@163.com
Country: China
ProdList: 10305
Advantage: 58

Chengdu Saint - Kay Biotechnology Co., Ltd.

Tel: 028-85157043 15882256948
Email: 676046971@qq.com
Country: China
ProdList: 4393
Advantage: 58

Hefei TNJ Chemical Industry Co.,Ltd.

Tel: 0551-65418684 +8618949823763
Fax: 0086-551-65418684
Email: sales@tnjchem.com
Country: China
ProdList: 25363
Advantage: 58

Dayang Chem (Hangzhou) Co.,Ltd.

Tel: 571-88938639 +8617705817739
Fax: +86-571-88938652，+86-571- 88492614
Email: info@dycnchem.com
Country: CHINA
ProdList: 52867
Advantage: 58

AFINE CHEMICALS LIMITED

Tel: 0571-85134551 18958018566;
Fax: 008657185134895
Email: info@afinechem.com
Country: China
ProdList: 15377
Advantage: 58

SIMAGCHEM CORP

Tel: +86-13806087780
Email: sale@simagchem.com
Country: China
ProdList: 17367
Advantage: 58

Chemwill Asia Co.,Ltd.

Tel: 86-21-51086038
Fax: 86-21-51861608
Email: chemwill_asia@126.com
Country: CHINA
ProdList: 23931
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9414
Advantage: 58

Xiamen AmoyChem Co., Ltd

Tel: +86-592-6051114 +8618959220845
Email: sales@amoychem.com
Country: China
ProdList: 6387
Advantage: 58

Zhongxiang Yaowei Biological Technology Co., Ltd.

Tel: 15337241005 13260682861
Email: w13260682861@qq.com
Country: China
ProdList: 2437
Advantage: 58

Chongqing Chemdad Co., Ltd

Tel: +86-023-61398051 +8613650506873
Email: sales@chemdad.com
Country: China
ProdList: 39916
Advantage: 58

CONIER CHEM AND PHARMA LIMITED

Tel: +8618523575427
Email: sales@conier.com
Country: China
ProdList: 49391
Advantage: 58

Absin Bioscience Inc.

Tel: 021-38015121 15000105423
Email: chenjw@absin.cn
Country: China
ProdList: 24734
Advantage: 58

Nanjing shengyilai Chemical Co., Ltd

Tel: 19951936396
Email: 3158688292@qq.com
Country: China
ProdList: 4840
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 025-85560043 15850508050
Fax: 025-85563444
Email: info@synzest.com
Country: China
ProdList: 9287
Advantage: 58

Mainchem Co., Ltd.

Tel: --
Fax: --
Email: sarah@mainchem.com
Country: China
ProdList: 6572
Advantage: 58

Hubei Baidu Chemical Co., Ltd

Tel: 13627137652
Fax: 027-59223020
Email: 1438180055@qq.com
Country: China
ProdList: 9994
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 29778
Advantage: 58

Beijing Stronger Science Co., Ltd.

Tel: 0531-88924771 15614660963
Email: elsa.hang@strongerscience.com
Country: China
ProdList: 10624
Advantage: 58

Nanjing Shizhou Biology Technology Co.,Ltd

Tel: 18351873721
Email: helen.zhang@synzest.com
Country: China
ProdList: 8298
Advantage: 58

Jiangxi ravel Biotechnology Co.,Ltd

Tel: 400-880-2824 15608648206
Email: 1987516016@qq.com
Country: China
ProdList: 2608
Advantage: 58

WEITIXIHAUGONG

Tel: 0371-53370800 18037197114
Email: 2853031799@qq.com
Country: China
ProdList: 10011
Advantage: 58

Shanghai Maclean Biochemical Technology Co., LTD

Tel: 021-50706066 15221275939
Email: shenlinxing@macklin.cn
Country: China
ProdList: 29803
Advantage: 58

Suzhou Zhixin Biotechnology Co., Ltd.

Tel: 0512-65118909 15162312715
Email: sales@szzxbio.com
Country: China
ProdList: 3001
Advantage: 58

Pushan Industry (Shaanxi) Co., Ltd.

Tel: 029-81310890 13571859809
Email: info@pushanshiye.com
Country: China
ProdList: 10004
Advantage: 58

Hubei Enxing Biotechnology Co., Ltd

Tel: 16621771607
Email: exbio_tech@163.com
Country: China
ProdList: 8352
Advantage: 58

Hubei Chenghai Chemical Co., Ltd

Tel: 18327245847 18327245847
Email: 1400838877@qq.com
Country: China
ProdList: 9992
Advantage: 58

Less

View Lastest Price from Almotriptan manufacturers

Career Henan Chemical Co

Product: Almotriptan 154323-57-6
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-21

154323-57-6, AlmotriptanRelated Search:

Minocycline Dimethyl carbonate Eletriptan hydrobromide Amorolfine Rizatriptan Zolmitriptan Sumatriptan 1,3-Bis(aminomethyl)benzene ETHANE Dimethyl ether N,N-Dimethylformamide Dimethyl fumarate Dimethyl sulfide Dacthal Eletriptan Dimethylamine hydrochloride Dimethyl sulfoxide Dimethylamine

LAS-31416-d6

ALMOTRIPTAN(SUBJECTTOPATENETFREE)

Almotriptan

N,N-Dimethyl-2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]-ethanamine

dimethyl-[2-[5-(pyrrolidin-1-ylsulfonylmethyl)-1H-indol-3-yl]ethyl]amine

AlMotriptan API

N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-1H-Indole-3-ethanamine

ALMOTRIPTAN-D6

1-[[[2-(Dimethyl-amino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine

1-[[3-(2-dimethylaminoethyl)-5-indolyl]methanesulphonyl]pyrrolidine

LAS-31416

1-[[[2-(Dimethyl-amino)ethyl]-1H-indol-5-yl]methyl]sulfonyl]pyrrolidine-d6

1-[[3-(2-dimethylaminoethyl)-5-indolyl]methanesulphonyl]pyrrolidine-d6

1H-Indole-3-ethanamine, N,N-dimethyl-5-[(1-pyrrolidinylsulfonyl)methyl]-

AlmotriptanQ: What is Almotriptan Q: What is the CAS Number of Almotriptan Q: What is the storage condition of Almotriptan Q: What are the applications of Almotriptan

154323-57-6

C17H19D6N3O2S

Intermediates & Fine Chemicals

Isotope Labeled Compounds

Pharmaceuticals

APIs

Isotope Labelled Compounds

Heterocyclic Compounds