4-AMINOMETHYLINDOLE

Product Name: 4-AMINOMETHYLINDOLE
CAS No.: 3468-18-6
Chemical Name: 4-AMINOMETHYLINDOLE
Synonyms: NSC 131886;4-AMINOMETHYLINDOLE;CHEMBRDG-BB 4003293;INDOLE-4-METHYLAMINE;1H-INDOLE-4-METHANAMINE;1H-Indol-4-ylmethanamine;(1H-Indol-4-ymetyl)amine;4-(Aminomethyl)indole 95%;(1H-INDOL-4-YLMETHYL)AMINE;C-(1H-INDOL-4-YL)-METHYLAMINE
CBNumber: CB7744486
Molecular Formula: C9H10N2
Formula Weight: 146.19
MOL File: 3468-18-6.mol

More

Less

4-AMINOMETHYLINDOLE Property

Melting point:: 132℃
Boiling point:: 335.6±17.0 °C(Predicted)
Density: 1.199
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: Soluble in ethanol, dimethyl sulfoxide and dimethyl formamide.
pka: 17.21±0.30(Predicted)
form: A crystalline solid

More

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-41-37/38-22
Safety Statements: 26-36/37/39
HazardClass: IRRITANT
HS Code: 2933998090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H318Causes serious eye damage

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More

Less

N-Bromosuccinimide Price

Cayman Chemical

Product number: 10007085
Product name: 4-Aminomethylindole
Purity: ≥99%
Packaging: 500mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 10007085
Product name: 4-Aminomethylindole
Purity: ≥99%
Packaging: 1g
Price: $110
Updated: 2024/03/01

Cayman Chemical

Product number: 10007085
Product name: 4-Aminomethylindole
Purity: ≥99%
Packaging: 5g
Price: $468
Updated: 2024/03/01

TRC

Product number: A633448
Product name: 4-Aminomethylindole
Packaging: 100mg
Price: $55
Updated: 2021/12/16

TRC

Product number: A633448
Product name: 4-Aminomethylindole
Packaging: 250mg
Price: $100
Updated: 2021/12/16

More

Less

4-AMINOMETHYLINDOLE Chemical Properties,Usage,Production

Description

4-Aminomethylindole is a synthetic intermediate useful for pharmaceutical synthesis.

Uses

4-Aminomethylindole is a useful research intermediate used in the preparation of dopamine receptor antagonist.

Uses

Reactant for preparation of dopamine receptor antagonists 1 Reactant for preparation of high-affinity ligands to α2δ subunit of voltage-gated calcium channels 2

Uses

4-(Aminomethyl)indole is used as a reactant for preparation of dopamine receptor antagonists and for preparation of high-affinity ligands to α2δ subunit of voltage-gated calcium channels. It is used as a synthetic intermediate.

Definition

ChEBI: 4-Aminomethylindole is a member of indoles.

Synthesis

16136-52-0

3468-18-6

The general procedure for the synthesis of 4-(aminomethyl)indole from 4-cyanoindole was as follows:Preparation of C-(1H-indol-4-yl)-methylamine. At room temperature, 4-cyanoindole (7.5 g, 53 mmol) was dissolved in THF (100 ml) and then slowly added to 1.0 M lithium aluminum hydride solution in THF (100 ml). The reaction mixture was heated to reflux for 30 min and subsequently cooled to room temperature. After completion of the reaction, the reaction mixture was quenched with 1N NaOH solution and filtered. The filtrate was acidified with 1N HCl and stirred at room temperature for 10 minutes. Subsequently, the pH was adjusted to about 10, saturated NaHCO3 solution was added and extracted with n-butanol. The organic layer was separated and concentrated to dryness. The residue was ground with methanol, filtered to remove insoluble matter and the filtrate was concentrated under reduced pressure to give the target product. The final product was dried under high vacuum at 50 °C to give a white solid (7.27 g, 94% yield).

References

[1] Journal of Medicinal Chemistry, 2010, vol. 53, # 6, p. 2646 - 2650
[2] Patent: US2012/238569, 2012, A1. Location in patent: Page/Page column 29
[3] European Journal of Medicinal Chemistry, 2017, vol. 134, p. 13 - 23
[4] Catalysis Science and Technology, 2014, vol. 4, # 3, p. 629 - 632

4-AMINOMETHYLINDOLE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

4-AMINOMETHYLINDOLE Suppliers

China 85 Germany 2 India 1 Switzerland 1 United Kingdom 4 United States 21 Global 114

Bridge Organics

Tel: +1269-649-4200
Fax: +1269-649-0611
Email: ab@bridgeorganics.com
Country: United States
ProdList: 162
Advantage: 55

Alchem Pharmtech,Inc.

Tel: 8485655694
Email: sales@alchempharmtech.com
Country: United States
ProdList: 63687
Advantage: 58

Aladdin Scientific

Tel
Email: tp@aladdinsci.com
Country: United States
ProdList: 57505
Advantage: 58

Sphinx Scientific Laboratory, LLC

Tel: --
Fax: --
Email: sales@sphinxscientificlab.com
Country: United States
ProdList: 3343
Advantage: 50

Carbocore, Inc.

Tel: --
Fax: --
Email: sales@carbocore.com
Country: United States
ProdList: 1436
Advantage: 60

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

Labseeker Inc

Tel: --
Fax: --
Email: marketing@labseeker.com
Country: United States
ProdList: 1495
Advantage: 55

Beta Pharma Scientific, Inc.

Tel: --
Fax: --
Email: sales@betapharma.com
Country: United States
ProdList: 251
Advantage: 0

Biofine International Inc.

Tel: --
Fax: --
Email: sales@biofineintl.com
Country: United States
ProdList: 653
Advantage: 38

Aagile Labs Division of Tyger Scientific

Tel: --
Fax: --
Email: tygersci@yahoo.com
Country: United States
ProdList: 6568
Advantage: 68

Chem-Impex International, Inc.

Tel: --
Fax: --
Country: United States
ProdList: 6730
Advantage: 64

Beta Pharma, Inc.

Tel: --
Fax: --
Email: sales@betapharma.com
Country: United States
ProdList: 6226
Advantage: 60

3B Scientific Corporation

Tel: --
Fax: --
Email: sales@3bsc.com
Country: United States
ProdList: 6718
Advantage: 47

ChemBridge Corporation

Tel: --
Fax: --
Email: resupply@chembridge.com
Country: United States
ProdList: 6648
Advantage: 70

Anichem LLC

Tel: --
Fax: --
Email: sales@anichemllc.com
Country: United States
ProdList: 4112
Advantage: 34

J & W PharmLab, LLC

Tel: --
Fax: --
Email: services@jwpharmlab.com
Country: United States
ProdList: 4156
Advantage: 63

Kalexsyn, Inc.

Tel: --
Fax: --
Email: jdbaker@kalexsyn.com
Country: United States
ProdList: 37
Advantage: 64

More

Less

View Lastest Price from 4-AMINOMETHYLINDOLE manufacturers

Career Henan Chemical Co

Product: 1H-indol-4-ylmethanamine 3468-18-6
Price: US $9.80/KG
Min. Order: 1KG
Purity: ≥98%
Supply Ability: 20 tons
Release date: 2020-01-09

3468-18-6, 4-AMINOMETHYLINDOLERelated Search:

Arbidol hydrochloride 4-AMINOMETHYLINDOLE 1H-INDOLE-6-METHANAMINE 2-BENZYL-5-AMINOMETHYLINDOLE (1H-INDOL-3-YL)METHANAMINE 4'-demethylamino-4'-hydroxystaurosporine K-252A ANTIBIOTIC UCN-02 STAUROSPORINE 3,6A,11,14-TETRAHYDRO-9-METHOXY-2-METHYL-(12H)-ISOQUINO[1,2-B]PYRROLO[3,2-F][1,3]BENZOXAZINE-1-CARBOXYLIC ACID, ETHYL ESTER K-252C ARCYRIAFLAVIN A SB218078 GO 6976 N-methyl-3-aminomethylindole N-nitroso-N-methyl-3-aminomethylindole 12-ETHYL-12,13-DIHYDRO-5H-INDOL[2,3A]PYRROLO[3,4C]CARBAZOLE-5,7(6H)-DIONE RARECHEM AL BT 0556

1H-INDOLE-4-METHANAMINE

(1H-INDOL-4-YLMETHYL)AMINE

4-AMINOMETHYLINDOLE

INDOLE-4-METHYLAMINE

CHEMBRDG-BB 4003293

C-(1H-INDOL-4-YL)-METHYLAMINE

NSC 131886

(1H-Indol-4-ymetyl)amine

1H-Indol-4-ylmethanamine

4-(Aminomethyl)indole 95%

(1H-indol-4-ylmethyl)amine(SALTDATA: FREE)

4-<WBR>(Aminomethyl)<WBR>indole

3468-18-6

pharmacetical