Paeonol
- Product Name
- Paeonol
- CAS No.
- 552-41-0
- Chemical Name
- Paeonol
- Synonyms
- Ethanone, 1-(2-hydroxy-4-methoxyphenyl)-;PEONOL;Paeonal;1-(2-HYDROXY-4-METHOXYPHENYL)ETHANONE;1-(2-HYDROXY-4-METHOXYPHENYL)ETHAN-1-ONE;Paeonol std.;2-Hydroxy-4-methoxy;Paeol;PAEONOL;Paeonolum
- CBNumber
- CB7745872
- Molecular Formula
- C9H10O3
- Formula Weight
- 166.17
- MOL File
- 552-41-0.mol
Paeonol Property
- Melting point:
- 48-50 °C(lit.)
- Boiling point:
- 154 °C / 20mmHg
- Density
- 1.3102
- refractive index
- 1.5452 (estimate)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- Acetonitrile (Slightly), Chloroform (Slightly), Methanol (Slightly)
- form
- Crystalline Powder
- pka
- 9.79±0.10(Predicted)
- color
- White to beige
- Odor
- Warm-aromatic odor
- Odor Type
- pungent
- BRN
- 1282794
- InChI
- InChI=1S/C9H10O3/c1-6(10)8-4-3-7(12-2)5-9(8)11/h3-5,11H,1-2H3
- InChIKey
- UILPJVPSNHJFIK-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=CC=C(OC)C=C1O)C
- LogP
- 1.980
- CAS DataBase Reference
- 552-41-0(CAS DataBase Reference)
- NIST Chemistry Reference
- Ethanone, 1-(2-hydroxy-4-methoxyphenyl)-(552-41-0)
Safety
- Hazard Codes
- Xn,Xi
- Risk Statements
- 20/21/22-36/37/38
- Safety Statements
- 26-28-36/37/39-45
- WGK Germany
- 3
- RTECS
- RT1215000
- Hazard Note
- Irritant
- HS Code
- 29145090
- Toxicity
- LD50 orl-mus: 3430 mg/kg YKKZAJ 89,1205,69
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- H35803
- Product name
- 2′-Hydroxy-4′-methoxyacetophenone
- Purity
- 99%
- Packaging
- 1g
- Price
- $27.3
- Updated
- 2024/03/01
- Product number
- H35803
- Product name
- 2′-Hydroxy-4′-methoxyacetophenone
- Purity
- 99%
- Packaging
- 10g
- Price
- $99.6
- Updated
- 2024/03/01
- Product number
- H0789
- Product name
- 2'-Hydroxy-4'-methoxyacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $21
- Updated
- 2024/03/01
- Product number
- H0789
- Product name
- 2'-Hydroxy-4'-methoxyacetophenone
- Purity
- >98.0%(GC)
- Packaging
- 25g
- Price
- $59
- Updated
- 2024/03/01
- Product number
- B22173
- Product name
- 2'-Hydroxy-4'-methoxyacetophenone, 99%
- Packaging
- 5g
- Price
- $45.65
- Updated
- 2024/03/01
Paeonol Chemical Properties,Usage,Production
Description
Paeonol is the main active ingredient of the cortex of thePaeonol raw materials with high purity can be derived from plant extracts by chemical synthesis. The commonly used extraction methods of paeonol include boiling method, alcohol extraction, steam distillation, and CO2 supercritical fluid extraction . But due to the limitation of plant resources and the lower content of paeonol in the natural plants, there are many separation and purification difficulties existed in the extraction methods. The chemical synthesis process is relatively easy, and the final product usually can be obtained through two- to three-step reaction and separation process . Ranunculaceae plants including Paeonia suffruticosa Andr. (Moutan cortex, Mudanpi) and Rhododendron plant Cynanchum paniculatum (Bge.) Kitag. (Cynanchi paniculati radix et rhizome, Xuchangqing). Moutan cortex and Xuchangqing are commonly used as traditional Chinese medicine. Moutan cortex has the effects on clearing heat, cooling blood, activating blood, resolving stasis, and retreating heat; Xuchangqing also has many effects, such as dispelling wind, relieving pain and itching, and so on.
Chemical Properties
white to beige crystalline powder
Physical properties
Appearance: white or light yellow, shining, needlelike crystals. Solubility: freely soluble in ethanol and methanol; soluble in diethyl ether, acetone, benzene, chloroform, and carbon disulfide; slightly soluble in water; and soluble in hot water, practically insoluble in cold water, and volatilizing in water vapor. Melting point: 48–51?°C.
History
As the main active ingredient of Moutan cortex and Xuchangqing, paeonol has been used in clinical practice since ancient times. Paeonol was first isolated from Moutan cortex by Japanese scholar Changjing Changyi in 1884 . This clinical observation was proceeded at more than 10 medical units in Shanghai and other places and lasted more than 1 year since 1971. Paeonol injection was the earliest recorded in the Chinese pharmacopoeia 1977 edition; it is the main formulation until now. But because of the poor water solubility of paeonol, it is necessary to improve its solubility to be used as injection. Ten times amount of Tween compared to paeonol was used in the injection to increase the dissolution. In the 1970s, paeonol was made into oil solution for intramuscular injection. But these are with security risks and the use of inconvenience and other shortcomings. Pharmacist obtained paeonol sodium sulfonate by sulfonated paeonol, so the problem of water solubility had been resolved, and the injection of paeonol sodium sulfonate also came into being . In 2003, the quality standard of paeonol sodium sulfonate was also promoted from the local standard to the national standard. The dosage form of paeonol for skin is mainly ointment.
Uses
Paeonol acting as a β-Secretase inhibitor an anti-apoptotic agent is used in the treatment of memory loss after ischemic stroke. Anti-inflammatory and analgesic.
Uses
antibacterial, antimutagen, anti-alzheimer
Uses
An anti-inflammatory & anti-lipid peroxidation agent
Preparation
Preparation by reaction of methyl iodide, or dimethyl sulfate on resacetophenone in sodium hydroxide or potassium hydroxide solution (quantitative yield) (70–75%).
Indications
This drug has been recorded in Pharmacopoeia of the People’s Republic of China (1977). At present, the dosage forms of paeonol for clinical use include tablet, ointment, injection, and plaster. Paeonol is clinically used for the treatment of fever, headache, neuralgia, muscle pain, abdominal pain, rheumatoid arthritis and rheumatoid arthritis; its ointment can also be used for a variety of eczema, dermatitis, skin itching, mosquito bite redness, and other skin diseases, also has a certain effect for allergic rhinitis, and is used for prevention of cold.
Definition
ChEBI: A natural product found in Paeonia rockii subspecies rockii.
General Description
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Pharmacology
Paeonol has a wide range of pharmacological activities, and its antibacterial, antiinflammatory, antipyretic, analgesic, and antispasmodic pharmacological effects have been well known. With the recent further study of pharmacological effects of paeonol, the improvement of cardiovascular and cerebrovascular function, liver and kidney care, and antitumor, immune regulation, antioxidant, and other new pharmacological activities have also been reported successively. Studies have shown that the protective effects of paeonol on cardiovascular and cerebrovascular systems are displayed in three aspects: it has antiarrhythmic activity because of the blocking effect on calcium channel current; it can affect the endothelial cell inflammatory response, thus protecting the blood vessels and improving blood circulation; and it can stabilize the cell membrane and inhibit myocardial ischemia and membrane damage. Paeonol inhibits the proliferation of a variety of tumor cells, such as human leukemia cell line K562, human breast cancer gene T6-17, hepatocellular carcinoma cell line BEL-7404, hepatoma cell line HepA, human leukemia tumor cell line K562/ADM, cervical cancer cell line HeLa, human large intestine cancer cell line HT-29, and so on. It can also sensitize the multidrug resistance of tumor cells to the chemotherapy drugs. Low concentration of paeonol can increase the proportion of T lymphocytes in the blood circulation and also make T lymphocytes play a stronger lymphokine separation function but also can promote the non-specific phagocytic removal of bacteria function of neutrophil. The role of systemic cellular immunity and humoral immune function has also been experimentally confirmed. In addition, paeonol has a strong effect on scavenging free radical; its antioxidant effect also enables paeonol’s applications in the pharmaceutical field and food preservation industry.
Clinical Use
In clinical practice, paeonol is mainly used as a major active ingredient of multiflavor traditional Chinese medicine. For example, paeonol is the main active ingredient and quality control index of more than ten kinds of commonly used Chinese medicine preparations, such as Feng Shi Ding tablets, Liu Wei Di Huang pills, Zheng Gu Shui water, Gui Shao Di Huang Tang pills, Mai Wei Di Huang pills, Qi Ju Di Huang tablets, Ming Mu Di Huang pills, Zhi Bai Di Huang pills, Gu Ci pills, Gu Ci Xiao Tong tablets, Fu Fang Yi Gan pills, Yang Yin Qing Fei Tang pills, JiSheng Shen Qi Wan pills, and Danggui Yangxue pills. In addition, paeonol can also be administered as a monomeric drug. The listed preparations are mainly paeonol injection, paeonol tablets, and paeonol ointment, clinically for the treatment of rheumatism, stomachache, and other pains, eczema, allergic dermatitis, etc. Paeonol and its preparations have the characteristics of less side effect, no addictive, nonrebound, and high security.
Safety Profile
Poison by intravenous route. Moderately toxic by ingestion and intraperitoneal routes. When heated to decomposition it emits acrid smoke and irritating fumes.
Paeonol Preparation Products And Raw materials
Raw materials
Preparation Products
Paeonol Suppliers
- Tel
- 029-84385017-8006 15891391030
- info@konochemical.com
- Country
- China
- ProdList
- 806
- Advantage
- 58
- Tel
- +86-0796-8118889-8030 +86-15907062626
- Fax
- 0796-8112278
- sales001@jxhcxl.com
- Country
- China
- ProdList
- 113
- Advantage
- 58
- Tel
- 021-52230662 13795399395
- sales@frchem.cn
- Country
- China
- ProdList
- 192
- Advantage
- 58
- Tel
- 027-87058617 13419515565
- Fax
- 13554237927
- 195755151@qq.com
- Country
- China
- ProdList
- 305
- Advantage
- 58
- Tel
- 0513-68819626; 15152877458
- Fax
- 0513-68669626
- feiyubio@163.com
- Country
- China
- ProdList
- 4821
- Advantage
- 58
- Tel
- 18679669723 18679669723
- 2134411736@qq.com
- Country
- China
- ProdList
- 290
- Advantage
- 58
- Tel
- 18266960953 18266960953
- 907697096@qq.com
- Country
- China
- ProdList
- 3033
- Advantage
- 58
- Tel
- 010-82848833 400-666-7788
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-61259108 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40240
- Advantage
- 62
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- sales@jonln.com
- Country
- China
- ProdList
- 1998
- Advantage
- 65
- Tel
- +86-21-20908456
- Fax
- 021-58180499
- sales@BioChemBest.com
- Country
- China
- ProdList
- 6008
- Advantage
- 61
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30132
- Advantage
- 84
- Tel
- +86 351 7031519
- Fax
- +86 351 7031519
- sales@RHFChem.com
- Country
- China
- ProdList
- 2341
- Advantage
- 56
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24539
- Advantage
- 81
- Tel
- 400-021-7337 2355568890
- Fax
- 0086-21-50182339
- sales@demochem.com
- Country
- China
- ProdList
- 2572
- Advantage
- 57
- Tel
- 010-60275820 13031183356
- Fax
- 010-60270825
- elainezt@sina.com
- Country
- China
- ProdList
- 1392
- Advantage
- 62
- Tel
- 010-89508211 18501085097
- Fax
- 010-89508210
- sales.bj@hwrkchemical.com
- Country
- China
- ProdList
- 8415
- Advantage
- 55
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44700
- Advantage
- 61
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- sales@capotchem.com
- Country
- China
- ProdList
- 18217
- Advantage
- 66
- Tel
- 010-82967028 13552068683
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12439
- Advantage
- 60
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9984
- Advantage
- 60
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11657
- Advantage
- 64
- Tel
- 86-027-88774375
- Fax
- 86-027-88416321
- mwmwhot@163.com
- Country
- China
- ProdList
- 233
- Advantage
- 65
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9816
- Advantage
- 59
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42959
- Advantage
- 64
- Tel
- 15527768850
- 1791901229@qq.com
- Country
- China
- ProdList
- 8846
- Advantage
- 52
- Tel
- 4009903999 13355009207
- Fax
- 0539-6365991
- 3007715519@qq.com
- Country
- China
- ProdList
- 18738
- Advantage
- 57
- Tel
- Fax
- E-Mail Inquiry
- info@syntechem.com
- Country
- China
- ProdList
- 12990
- Advantage
- 57
- Tel
- 400-1166-196 18981987031
- Fax
- 028-84555506 800101999
- cdhxsj@163.com
- Country
- China
- ProdList
- 11726
- Advantage
- 57
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7815
- Advantage
- 57
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14443
- Advantage
- 57
- Tel
- 86-21-63210123
- Fax
- 86-21-63290778 86-21-63218885
- sj_scrc@sinopharm.com
- Country
- China
- ProdList
- 9823
- Advantage
- 79
- Tel
- 86-28-85159085
- Fax
- 86-28-85152372
- info@aktinchem.com
- Country
- China
- ProdList
- 297
- Advantage
- 62
- Tel
- +86-0755-89668383
- Fax
- +86-0755-89594066/4038
- sales@sungening.com
- Country
- China
- ProdList
- 1319
- Advantage
- 65
- Tel
- 0370-2785118 17550508557
- Fax
- QQ：3470079902
- 675141927@qq.com
- Country
- China
- ProdList
- 3207
- Advantage
- 55
- Tel
- 027-59207852 13308628970
- Fax
- QQ3130921841
- buy@fortunachem.com
- Country
- China
- ProdList
- 2877
- Advantage
- 58
- Tel
- 0411-62910999 13889544652
- meilunui@163.com
- Country
- China
- ProdList
- 4672
- Advantage
- 58
- Tel
- 0871-65217109 13211707573;
- Fax
- 0871-65215563
- y.liu@mail.biobiopha.com
- Country
- China
- ProdList
- 5654
- Advantage
- 65
- Tel
- 021-61312847 13636370518
- Fax
- 021-55068248
- shyysw007@163.com
- Country
- China
- ProdList
- 4941
- Advantage
- 60
- Tel
- 4008-755-333 18080918076
- Fax
- 028-86757656
- 800078821@qq.com
- Country
- China
- ProdList
- 9725
- Advantage
- 55
- Tel
- 021-61551611 13296011611
- Fax
- ＋86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9900
- Advantage
- 58
- Tel
- 028-83311324 1278112614
- Fax
- 028-83311324
- climaxbiotech@gmail.com
- Country
- China
- ProdList
- 925
- Advantage
- 58
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9872
- Advantage
- 52
- Tel
- 86-029-85456576
- Fax
- 86-029-85456576-808
- daisy_wang@vip.163.com
- Country
- China
- ProdList
- 292
- Advantage
- 55
- Tel
- 025-84430028 13815430202
- sale02@cqherb.com
- Country
- China
- ProdList
- 280
- Advantage
- 59
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17779
- Advantage
- 75
- Tel
- 010-56205725
- Fax
- 010-65763397
- waley188@sohu.com
- Country
- China
- ProdList
- 12338
- Advantage
- 58
- Tel
- 400-810-7969 010-59572699
- Fax
- 010-59572688
- ningzi.li@inno-chem.com.cn
- Country
- China
- ProdList
- 6139
- Advantage
- 55
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18216
- Advantage
- 56
- Tel
- 400-400-6206333 18521732826
- Fax
- 021-50323701
- market@aladdin-e.com
- Country
- China
- ProdList
- 25009
- Advantage
- 65
View Lastest Price from Paeonol manufacturers
- Product
- Paeonol; Peony root bark extract 552-41-0
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- ≥98% HPLC
- Supply Ability
- 1000KG
- Release date
- 2022-09-28
- Product
- Paeonol 552-41-0
- Price
- US $50.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 5000kg/Week
- Release date
- 2024-04-23
- Product
- Paeonol 552-41-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50 ton
- Release date
- 2024-08-20