Monensin sodium salt

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Monensin sodium salt

Product Name: Monensin sodium salt
CAS No.: 22373-78-0
Chemical Name: Monensin sodium salt
Synonyms: Coban;RUMENSIN;Coban45;Sodiummonensin;MONENSINSODIUM,USP;Monensin sodium 40%;Monensin sodium salt;Previouscas:22136-43-2;Monensin sodium, 90-95%;monensin,monosodiumsalt
CBNumber: CB7748020
Molecular Formula: C36H63NaO12
Formula Weight: 710.87
MOL File: 22373-78-0.mol

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Monensin sodium salt Property

Melting point:: 267-269 C
alpha: 57.3 º (c=4.0, in MeOH)
storage temp.: 2-8°C
solubility: Soluble in methanol at 50mg/ml
form: Off-white to beige solid
color: White
BRN: 4122200
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey: XOIQMTLWECTKJL-BEMBKCOJSA-M
LogP: 3.716 (est)
EPA Substance Registry System: Monensin, monosodium salt (22373-78-0)

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Safety

Hazard Codes: T,T+
Risk Statements: 25-26/27/28
Safety Statements: 36/37/39-45-22
RIDADR: UN 3462 6.1/PG 2
WGK Germany: 3
RTECS: JH2830000
HazardClass: 6.1(a)
PackingGroup: II
HS Code: 29419090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H373May cause damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHR2775
Product name: Monensin sodium
Purity: PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial,certifiedrefer
Packaging: 300MG
Price: $158
Updated: 2024/03/01

Sigma-Aldrich

Product number: 46468
Product name: Monensin sodium salt hydrate
Purity: VETRANAL
Packaging: 100mg
Price: $57.7
Updated: 2024/03/01

Sigma-Aldrich

Product number: 1445481
Product name: Monensin sodium
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 200mg
Price: $436
Updated: 2024/03/01

Alfa Aesar

Product number: J61669
Product name: Monensin sodium salt, 90% min.
Packaging: 1g
Price: $66.2
Updated: 2024/03/01

Cayman Chemical

Product number: 16488
Product name: Monensin (sodium salt)
Purity: ≥98%
Packaging: 1g
Price: $50
Updated: 2024/03/01

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Monensin sodium salt Chemical Properties,Usage,Production

Description

Monensin is a naturally occuring ionophorous antibiotic that preferentially forms complexes with monovalent cations to enable transport across lipid membranes. Through its ability to affect pH and the sodium-potassium balance of a cell, monensin can induce cell death in Gram-positive bacteria such as Micrococcus, Bacillus, and Staphylococcus (MICs = 1-12.5 μg/ml), reduce proliferation of P. falciparum and Coccicdium protozoa, and also prevent replication of certain viruses.

Chemical Properties

LIGHT CREAM AMORPHOUS POWDER

Uses

Poliether antibiotic. Coccidiostat.

Uses

antifungal

Uses

antibacterial

Uses

Monensin sodium salt is used in potentiometric and spectroscopic studies of alkali metal ion complexes. Monensin (Na) is a polyether small molecule ionophore, capable of forming stable complexes to monovalent cations with specific affinity for Na+. Monensin presents a highly lipophilic scaffold around the bound ion, allowing movement of the complex through the lipid bilayer and consequent transport of the ion out of the cell. Excessive flux of ions out of the cell produces a cytotoxic effect and generates the antibiotic properties of Monensin.

General Description

Monensin is a polyether ionophoric antibiotic, which is produced by Streptomyces cinnamonensis. It is used to treat bacterial, fungal and parasitic infections. Monensin prevents the growth of colon cancer cells. It facilitates the transport of sodium and potassium ions between intracellular and extracellular spaces. Monensin prevents coccidiosis?in poultry production.

Biochem/physiol Actions

Na+ ionophore; blocks glycoprotein secretion; may induce catecholamine secretion from chromaffin cells. Useful in potentiometric and spectroscopic studies of alkali metal ion complexes.

storage

-20°C

Purification Methods

Crystallise it from EtOH/H2O [Cox et al. J Am Chem Soc 107 4297 1985].

References

Aowicki and Huczynski (2013), Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements; Res. Int. 2013 742149 Kallen et al. (1993), Monensin inhibits synthesis of plasma membrane sphingomyelin by blocking transport of ceramide through the Golgi: evidence for two sites of sphingomyelin synthesis in BHK cells; Biophys. Acta 1166 305 Boss et al. (1984), Monensin-induced swelling of Golgi apparatus cisternae mediated by a proton gradient; J. Cell. Biol. 34 1 Mollenhauer et al. (1990), Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity; Biophys. Acta 1031 225 Hafner et al. (2021), The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells; Pharmacol. 12 611657 Oh-Hashi et al. (2021), Comparative Analysis of CREB3 and CREB3L2 Protein Expression in HEK293 Cells; J. Mol. Sci. 22 2767

Monensin sodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Monensin sodium salt manufacturers

Henan Fengda Chemical Co., Ltd

Product: Monensin sodium salt 22373-78-0
Price: US $3.00-1.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-16

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Monensin Sodium 22373-78-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000kg
Release date: 2024-04-07

Hebei Duling International Trade Co. LTD

Product: Monensin sodium salt 22373-78-0
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 1
Release date: 2022-09-20

22373-78-0, Monensin sodium saltRelated Search:

Abamectin Natamycin Sodium hydroxide Ivermectin Nystatin Sodium benzoate Sodium bicarbonate Disodium phosphonomycin Diclofenac sodium Rifamycin Sodium Sodium acetate Sodium chloride 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT 3,6,9,12-tetraoxatetradecan-1-ol 2-[2-[(2-ETHYLHEXYL)OXY]ETHOXY]ETHANOL PENTACOSANOIC ACID Monensin GLYCOFUROL

Coban45

gamma,2,8-tetramethyl--furyl)-2-furyl)-9-hydroxy-beta-methoxy-alphmonosod

methyl-5-(tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2h-pyran-2-yl)-2

monensin,monosodiumsalt

Monensin,monosodiumsalt(9CI)

Previouscas:22136-43-2

Sodiummonensin

2-[5-Ethyltetrahydro-5-[tetrahydro-3-Methyl-5-[tetrahydro-6-hydroxy-6-(hydroxyMethyl)-3,5-diMethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β-Methoxy-α,γ,2,8-tetraMethyl-

MONENSIN SODIUM (Monensin A is shown)

1,6-Dioxaspiro[4.5]decane-7-butyric acid, 2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β-methoxy-α,γ,2,8-tetramethyl-, monosodium salt (8CI)

Monensin sodium, 90-95%

Monensin sodium 20/40%/90%

1,6-Dioxaspiro[4.5]decane-7-butyricacid,2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-.beta.-methoxy-.alpha.,.gamma.-2,8-tetramethyl-,monosodiumsal

1,6-Dioxaspiro[4.5]decane-7-butyricacid,2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-.beta.-methoxy-.alpha.,.gamma.-2,8-tetramethyl-,monosodiumsalt

Coban

MONENSIN SODIUM SALT 97%

MONENSIN SODIUM SALT HYDRATE

RUMENSIN

MONENSINSODIUM,USP

1,6-Dioxaspiro[4.5] decane-7-butyric acid, 2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5- [tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9- hydroxy-.beta.-methoxy-.alpha.,.gamma.-2,8-tetramethyl-, monosodium salt

Monensin sodium salt

4-[2-[5-Ethyl-5-[5-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-oxan-2-yl]-3-methyl-oxolan-2-yl]oxolan-2-yl]-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl]-3-methoxy-2-methyl-pentanoic acid monosodium salt

Monensin, sodium salt,97%

1,6-Dioxaspiro[4.5]decane-7-butyric acid, 2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydrox y-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-.beta.-metho xy-.alpha.,.gamma.,2,8-tetramethyl-, monosodium salt (8CI

Sodium 4-[2-[2-Ethyl-3'-methyl-5'-(tetrahydro-6-hydroxy-6-hydroxymethyl-3,5-dimethylpyran-2-yl)perhydro-2,2'-bifuran-5-yl]-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl}-3-methoxy-2-methylpentanoate

Monensin Sodium (200 mg)

Monensin sodium salt,Monensin A sodium salt

Monensin sodiuM salt(Coban)

Monensin sodium 40%

2-[5-Ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-β-methoxy-α,γ,2,8-tetramethyl-1,6-Dioxaspiro[4.5]decane-7-butyric acid sodium salt

Monensin, Sodium Salt, High Purity - CAS 22373-78-0 - Calbiochem

Monensin sodium salt, 90+ %

Sodium (2S,3R,4S)-4-[(2S,5R,7S,8R,9S)-2-[(2S,2'R,3'S,5R,5'R)-2-Ethyl-5'-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl]-3'-methyloctahydro-[2,2'-bifuran]-5-yl]-9-hydroxy-2,8-dimethyl-

Monensin sodium salt USP/EP/BP

Sodium (2S,3R,4S)-4-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,5R,5'R)-2-ethyl-5'-((2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-3'-methyloctahydro-[2,2'-bifuran]-5-yl)-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]decan-7-yl)-3-methoxy-2-methylpentanoate

Monensin Sodium Salt (MSN), 90-95%

22373-78-0

C36H61NaO11

C36H63NaO12

C36H61NaO11xH2O

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22373-78-0