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Monensin sodium salt

Product Name
Monensin sodium salt
CAS No.
22373-78-0
Chemical Name
Monensin sodium salt
Synonyms
Coban;RUMENSIN;Coban45;Sodiummonensin;Monomycin sodium;MONENSINSODIUM,USP;Monensin sodium 40%;Monensin sodium salt;Previouscas:22136-43-2;Monensin sodium, 90-95%
CBNumber
CB7748020
Molecular Formula
C36H63NaO12
Formula Weight
710.87
MOL File
22373-78-0.mol
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Monensin sodium salt Property

Melting point:
267-269 C
alpha 
57.3 º (c=4.0, in MeOH)
storage temp. 
2-8°C
solubility 
Soluble in methanol at 50mg/ml
form 
Off-white to beige solid
color 
White
BRN 
4122200
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey
XOIQMTLWECTKJL-BEMBKCOJSA-M
LogP
3.716 (est)
EPA Substance Registry System
Monensin, monosodium salt (22373-78-0)
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Safety

Hazard Codes 
T,T+
Risk Statements 
25-26/27/28
Safety Statements 
36/37/39-45-22
RIDADR 
UN 3462 6.1/PG 2
WGK Germany 
3
RTECS 
JH2830000
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
29419090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H300Fatal if swallowed

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H373May cause damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2775
Product name
Monensin sodium
Purity
PharmaceuticalSecondaryStandard;CertifiedReferenceMaterial,certifiedrefer
Packaging
300MG
Price
$158
Updated
2024/03/01
Sigma-Aldrich
Product number
46468
Product name
Monensin sodium salt hydrate
Purity
VETRANAL
Packaging
100mg
Price
$57.7
Updated
2024/03/01
Sigma-Aldrich
Product number
1445481
Product name
Monensin sodium
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Alfa Aesar
Product number
J61669
Product name
Monensin sodium salt, 90% min.
Packaging
1g
Price
$66.2
Updated
2024/03/01
Cayman Chemical
Product number
16488
Product name
Monensin (sodium salt)
Purity
≥98%
Packaging
1g
Price
$50
Updated
2024/03/01
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Monensin sodium salt Chemical Properties,Usage,Production

Description

Monensin is a naturally occuring ionophorous antibiotic that preferentially forms complexes with monovalent cations to enable transport across lipid membranes. Through its ability to affect pH and the sodium-potassium balance of a cell, monensin can induce cell death in Gram-positive bacteria such as Micrococcus, Bacillus, and Staphylococcus (MICs = 1-12.5 μg/ml), reduce proliferation of P. falciparum and Coccicdium protozoa, and also prevent replication of certain viruses.

Chemical Properties

LIGHT CREAM AMORPHOUS POWDER

Uses

Poliether antibiotic. Coccidiostat.

Uses

antifungal

Uses

antibacterial

Uses

Monensin sodium salt is used in potentiometric and spectroscopic studies of alkali metal ion complexes. Monensin (Na) is a polyether small molecule ionophore, capable of forming stable complexes to monovalent cations with specific affinity for Na+. Monensin presents a highly lipophilic scaffold around the bound ion, allowing movement of the complex through the lipid bilayer and consequent transport of the ion out of the cell. Excessive flux of ions out of the cell produces a cytotoxic effect and generates the antibiotic properties of Monensin.

General Description

Monensin is a polyether ionophoric antibiotic, which is produced by Streptomyces cinnamonensis. It is used to treat bacterial, fungal and parasitic infections. Monensin prevents the growth of colon cancer cells. It facilitates the transport of sodium and potassium ions between intracellular and extracellular spaces. Monensin prevents coccidiosis?in poultry production.

Biochem/physiol Actions

Na+ ionophore; blocks glycoprotein secretion; may induce catecholamine secretion from chromaffin cells. Useful in potentiometric and spectroscopic studies of alkali metal ion complexes.

storage

-20°C

Purification Methods

Crystallise it from EtOH/H2O [Cox et al. J Am Chem Soc 107 4297 1985].

References

Aowicki and Huczynski (2013), Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements; Res. Int. 2013 742149 Kallen et al. (1993), Monensin inhibits synthesis of plasma membrane sphingomyelin by blocking transport of ceramide through the Golgi: evidence for two sites of sphingomyelin synthesis in BHK cells; Biophys. Acta 1166 305 Boss et al. (1984), Monensin-induced swelling of Golgi apparatus cisternae mediated by a proton gradient; J. Cell. Biol. 34 1 Mollenhauer et al. (1990), Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity; Biophys. Acta 1031 225 Hafner et al. (2021), The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells; Pharmacol. 12 611657 Oh-Hashi et al. (2021), Comparative Analysis of CREB3 and CREB3L2 Protein Expression in HEK293 Cells; J. Mol. Sci. 22 2767

Monensin sodium salt Preparation Products And Raw materials

Raw materials

Preparation Products

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Monensin sodium salt Suppliers

Austria 1 Belgium 1 Brazil 1 Canada 3 China 268 Czech Republic 1 Europe 3 France 1 Germany 4 India 8 Italy 1 Japan 3 Poland 1 Singapore 1 South Korea 1 Switzerland 3 United Kingdom 11 United States 33 Global 345
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
Wako Pure Chemical Industries, Ltd.
Tel
--
Fax
--
Email
labchem-tec@wako-chem.co.jp
Country
Japan
ProdList
6819
Advantage
80
Kanto Chemical Co., Inc.
Tel
--
Fax
--
Email
reag-info@gms.kanto.co.jp
Country
Japan
ProdList
6756
Advantage
74
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View Lastest Price from Monensin sodium salt manufacturers

Shandong Deshang Chemical Co., Ltd.
Product
Monensin sodium salt 22373-78-0
Price
US $6.90-4.20/kg
Min. Order
1kg
Purity
99%
Supply Ability
10 tons
Release date
2024-06-28
Hebei Yanxi Chemical Co., Ltd.
Product
Monensin sodium salt 22373-78-0
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20tons
Release date
2023-09-21
Hebei Chuanghai Biotechnology Co,.LTD
Product
Monensin Sodium Salt 22373-78-0
Price
US $100.00-80.00/KG
Min. Order
10KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-22

22373-78-0, Monensin sodium saltRelated Search:

Abamectin Natamycin Sodium hydroxide Ivermectin Nystatin Sodium benzoate Sodium bicarbonate Disodium phosphonomycin Diclofenac sodium Rifamycin Sodium Sodium acetate Sodium chloride 8-CHLOROADENOSINE-3',5'-CYCLIC MONOPHOSPHOROTHIOATE, RP-ISOMER SODIUM SALT 3,6,9,12-tetraoxatetradecan-1-ol 2-[2-[(2-ETHYLHEXYL)OXY]ETHOXY]ETHANOL PENTACOSANOIC ACID Monensin GLYCOFUROL

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  • 1,6-Dioxaspiro[4.5]decane-7-butyricacid,2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-.beta.-methoxy-.alpha.,.gamma.-2,8-tetramethyl-,monosodiumsalt
  • Coban
  • MONENSIN SODIUM SALT 97%
  • MONENSIN SODIUM SALT HYDRATE
  • RUMENSIN
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  • 1,6-Dioxaspiro[4.5] decane-7-butyric acid, 2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5- [tetrahydro-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9- hydroxy-.beta.-methoxy-.alpha.,.gamma.-2,8-tetramethyl-, monosodium salt
  • Monensin sodium salt
  • 4-[2-[5-Ethyl-5-[5-[6-hydroxy-6-(hydroxymethyl)-3,5-dimethyl-oxan-2-yl]-3-methyl-oxolan-2-yl]oxolan-2-yl]-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]dec-7-yl]-3-methoxy-2-methyl-pentanoic acid monosodium salt
  • Monensin, sodium salt,97%
  • 1,6-Dioxaspiro[4.5]decane-7-butyric acid, 2-[5-ethyltetrahydro-5-[tetrahydro-3-methyl-5-[tetrahydro-6-hydrox y-6-(hydroxymethyl)-3,5-dimethyl-2H-pyran-2-yl]-2-furyl]-2-furyl]-9-hydroxy-.beta.-metho xy-.alpha.,.gamma.,2,8-tetramethyl-, monosodium salt (8CI
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  • Monensin, Sodium Salt, High Purity - CAS 22373-78-0 - Calbiochem
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  • Sodium (2S,3R,4S)-4-[(2S,5R,7S,8R,9S)-2-[(2S,2'R,3'S,5R,5'R)-2-Ethyl-5'-[(2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl]-3'-methyloctahydro-[2,2'-bifuran]-5-yl]-9-hydroxy-2,8-dimethyl-
  • Monensin sodium salt USP/EP/BP
  • Sodium (2S,3R,4S)-4-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,5R,5'R)-2-ethyl-5'-((2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-3'-methyloctahydro-[2,2'-bifuran]-5-yl)-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]decan-7-yl)-3-methoxy-2-methylpentanoate
  • Sodium (2S,3R,4S)-4-((2S,5R,7S,8R,9S)-2-((2S,2'R,3'S,5R,5'R)-2-ethyl-5'-((2S,3S,5R,6R)-6-hydroxy-6-(hydroxymethyl)-3,5-dimethyltetrahydro-2H-pyran-2-yl)-3'-methyloctahydro-[2,2'-bifuran]-5-yl)-9-hydroxy-2,8-dimethyl-1,6-dioxaspiro[4.5]decan-7-yl)-3-methox
  • Monensin Sodium Salt (MSN), 90-95%
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  • Monensin sodium salt, 90+ % in methanol
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  • 22373-78-0
  • C36H61NaO11
  • C36H63NaO12
  • C36H61NaO11xH2O
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  • 22373-78-0