Monensin sodium salt

Monensin sodium salt Property

Melting point:

267-269 C

alpha 

57.3 º (c=4.0, in MeOH)

storage temp. 

2-8°C

solubility 

Soluble in methanol at 50mg/ml

form 

Off-white to beige solid

color 

White

BRN 

4122200

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

InChIKey

XOIQMTLWECTKJL-BEMBKCOJSA-M

LogP

3.716 (est)

EPA Substance Registry System

Monensin, monosodium salt (22373-78-0)

Safety

Hazard Codes 

T,T+

Risk Statements 

25-26/27/28

Safety Statements 

36/37/39-45-22

RIDADR 

UN 3462 6.1/PG 2

WGK Germany 

3

RTECS 

JH2830000

HazardClass 

6.1(a)

PackingGroup 

II

HS Code 

29419090

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H373May cause damage to organs through prolonged or repeated exposure

H411Toxic to aquatic life with long lasting effects

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Monensin sodium salt Chemical Properties,Usage,Production

Description

Monensin is a naturally occuring ionophorous antibiotic that preferentially forms complexes with monovalent cations to enable transport across lipid membranes. Through its ability to affect pH and the sodium-potassium balance of a cell, monensin can induce cell death in Gram-positive bacteria such as Micrococcus, Bacillus, and Staphylococcus (MICs = 1-12.5 μg/ml), reduce proliferation of P. falciparum and Coccicdium protozoa, and also prevent replication of certain viruses.

Chemical Properties

LIGHT CREAM AMORPHOUS POWDER

Uses

Poliether antibiotic. Coccidiostat.

Uses

antifungal

Uses

antibacterial

Uses

Monensin sodium salt is used in potentiometric and spectroscopic studies of alkali metal ion complexes. Monensin (Na) is a polyether small molecule ionophore, capable of forming stable complexes to monovalent cations with specific affinity for Na+. Monensin presents a highly lipophilic scaffold around the bound ion, allowing movement of the complex through the lipid bilayer and consequent transport of the ion out of the cell. Excessive flux of ions out of the cell produces a cytotoxic effect and generates the antibiotic properties of Monensin.

General Description

Monensin is a polyether ionophoric antibiotic, which is produced by Streptomyces cinnamonensis. It is used to treat bacterial, fungal and parasitic infections. Monensin prevents the growth of colon cancer cells. It facilitates the transport of sodium and potassium ions between intracellular and extracellular spaces. Monensin prevents coccidiosis?in poultry production.

Biochem/physiol Actions

Na+ ionophore; blocks glycoprotein secretion; may induce catecholamine secretion from chromaffin cells. Useful in potentiometric and spectroscopic studies of alkali metal ion complexes.

storage

-20°C

Purification Methods

Crystallise it from EtOH/H2O [Cox et al. J Am Chem Soc 107 4297 1985].

References

[1] DANIEL AOWICKI  Adam H. Structure and antimicrobial properties of monensin A and its derivatives: summary of the achievements.[J]. BioMed Research International, 2013: 742149. DOI:10.1155/2013/742149
[2] KARL-JOSEF KALLEN  David A  Paul Quinn. Monensin inhibits synthesis of plasma membrane sphingomyelin by blocking transport of ceramide through the Golgi: Evidence for two sites of sphingomyelin synthesis in BHK cells[J]. Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1993, 1166 2: Pages 305-308. DOI:10.1016/0005-2760(93)90111-l
[3] W F BOSS  H H M  D J Morré. Monensin-induced swelling of Golgi apparatus cisternae mediated by a proton gradient.[J]. European journal of cell biology, 1984, 34 1: 1-8.
[4] HILTON H. MOLLENHAUER  Loyd D R  D James Morré. Alteration of intracellular traffic by monensin; mechanism, specificity and relationship to toxicity[J]. Biochimica et Biophysica Acta (BBA) - Reviews on Biomembranes, 1990, 1031 2: Pages 225-246. DOI:10.1016/0304-4157(90)90008-z
[5] SUSANNE HAFNER S J L Michael Schmiech. The Cardenolide Glycoside Acovenoside A Interferes with Epidermal Growth Factor Receptor Trafficking in Non-Small Cell Lung Cancer Cells.[J]. ACS Applied Energy Materials, 2021: 611657. DOI:10.3389/fphar.2021.611657
[6] KENTARO OH-HASHI. Comparative Analysis of CREB3 and CREB3L2 Protein Expression in HEK293 Cells.[J]. International Journal of Molecular Sciences, 2021, 22 5. DOI:10.3390/ijms22052767