ChemicalBook > CAS DataBase List > SKF 96365 HYDROCHLORIDE

SKF 96365 HYDROCHLORIDE

Product Name: SKF 96365 HYDROCHLORIDE
CAS No.: 130495-35-1
Chemical Name: SKF 96365 HYDROCHLORIDE
Synonyms: CS-2170;SKF 96365;SKF 96365 HCI;SKF-96365, HC;SKF-96365, HCl;SK AND F 96365;SKF-96365;SKF 96365;SKF 96365 hydrochlor;SKF 96365 HYDROCHLORIDE;SKF 96365, TRP channel blocker
CBNumber: CB7752278
Molecular Formula: C22H27ClN2O3
Formula Weight: 402.91
MOL File: 130495-35-1.mol

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SKF 96365 HYDROCHLORIDE Property

Melting point:: 119 °C
RTECS: NI6823500
storage temp.: Inert atmosphere,Room Temperature
solubility: H₂O: >20 mg/mL
form: solid
color: white
Water Solubility: Soluble to 100mM in water
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS DataBase Reference: 130495-35-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2933.29.4300

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S7809
Product name: SKF-96365
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $209
Updated: 2025/07/31

Sigma-Aldrich

Product number: 567310-M
Product name: SKF-96365, Hydrochloride
Purity: Inhibits receptor-mediated Ca<sup>2+</sup> entry in activated platelets, neutrophils, and endothelial cells at concentrations that do not affect internal Ca<sup>2+</sup> release.
Packaging: 1 unit
Price: $165
Updated: 2025/07/31

TCI Chemical

Product number: K0066
Product name: SKF-96365
Packaging: 10MG
Price: $230
Updated: 2025/07/31

TCI Chemical

Product number: K0066
Product name: SKF-96365
Packaging: 50MG
Price: $377
Updated: 2025/07/31

Cayman Chemical

Product number: 10009312
Product name: SKF 96365 (hydrochloride)
Purity: ≥98%
Packaging: 1mg
Price: $20
Updated: 2024/03/01

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SKF 96365 HYDROCHLORIDE Chemical Properties,Usage,Production

Description

SKF-96365 (130495-35-1) is an inhibitor of receptor-mediated calcium entry (RMCE) with IC50‘s of 8.5 μM for ADP stimulated platelets and 11.7 μM for thrombin stimulated platelets. Also inhibits Voltage-gated Ca2+ but not ATP-gated Ca2+ entry.1 It has also been shown to block transient receptor potential canonical type (TRPC) channels2, high-voltage-activated (HVA) L-type channels1, K channels3, sarcoplasmic reticulum Ca-ATPase4 and voltage-gated sodium channels5. SKF-96365 is a potent blocker of LVA T-type Ca channels, in particular Ca(V)3.1 (IC50 = 0.56 μM).6

Uses

SKF 96365 Hydrochloride is a novel inhibitor of receptor-mediated calcium entry.

Definition

ChEBI: SKF-96365 hydrochloride is the hydrochloride salt of SKF-96365. It is a TRP channel blocker. It has a role as a TRP channel blocker, an apoptosis inducer, an autophagy inducer, a GABA antagonist, an antineoplastic agent, a calcium channel blocker and a platelet aggregation inhibitor. It contains a SKF-96365 free base(1+).

General Description

Inhibits receptor-mediated Ca²⁺ entry in stimulated platelets (IC₅₀ = 8-12 μM in intact platelets), neutrophils, and endothelial cells (IC₅₀ = 30 μM for human endothelial cells) at concentrations that do not affect internal Ca²⁺ release. Also inhibits voltage-gated Ca²⁺ entry in excitable cells. Inhibits the histamine-induced formation of nitric oxide in human endothelial cells.

Biological Activity

Store-operated Ca 2+ entry (SOCE) inhibitor that inhibits STIM1. Also inhibits TRP channels, voltage-gated Ca 2+ channels and potassium channels.

Biochem/physiol Actions

SKF-96365 with an alkylated imidazole ring is a selective inhibitor of receptor-mediated Ca2+?entry and voltage-gated Ca2+?entry . SKF-96365 mediated depolarization of smooth cardiac muscle membrane and had no impact on the acetylcholine (ACh)-induced depolarization. It is an inhibitor for SOCE (store-operated calcium entry). It also inhibits Homer1 protein expression. SKF-96365 elicits protective functionality in 1-methyl-4-phenylpyridinium(MPP) mediated cytotoxicity.

storage

Store at RT

References

[1] J E MERRITT. SK&F 96365, a novel inhibitor of receptor-mediated calcium entry.[J]. Biochemical Journal, 1990, 271 2: 515-522. DOI:10.1042/bj2710515
[2] KIRILL KISELYOV. Functional interaction between InsP3 receptors and store-operated Htrp3 channels[J]. Nature, 1998, 396 6710: 478-482. DOI:10.1038/24890
[3] G. SCHWARZ B. N G Droogmans. Multiple effects of SK&F 96365 on ionic currents and intracellular calcium in human endothelial cells[J]. Cell calcium, 1994, 15 1: Pages 45-54. DOI:10.1016/0143-4160(94)90103-1
[4] M J MASON L J H B Mayer. Inhibition of Ca2+ transport pathways in thymic lymphocytes by econazole, miconazole, and SKF 96365.[J]. American Journal of Physiology, 1993, 264 3 Pt 1: C654-62. DOI:10.1152/ajpcell.1993.264.3.c654
[5] S. J. HONG C che C Wan Wan Lin. Inhibition of the Sodium Channel by SK&F 96365, an Inhibitor of the Receptor-Operated Calcium Channel, in Mouse Diaphragm.[J]. Journal of Biomedical Science, 1994, 3 1: 172-178. DOI:10.1007/bf02253347
[6] A SINGH. The transient receptor potential channel antagonist SKF96365 is a potent blocker of low-voltage-activated T-type calcium channels[J]. British Journal of Pharmacology, 2010, 160 6: 1464-1475. DOI:10.1111/j.1476-5381.2010.00786.x

SKF 96365 HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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SKF 96365 HYDROCHLORIDE Suppliers

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130495-35-1, SKF 96365 HYDROCHLORIDERelated Search:

(+/-)-BAY K 8644 Vanoxerine dihydrochloride AFC Nicardipine hydrochloride Octyl 4-methoxycinnamate Cinnamyl alcohol 4-Methoxyphenol Methoxyacetic acid 4-Methoxybenzoic acid MSK-195 L-Menthol IMIDAZOLE HYDROCHLORIDE 1-Phenyl-2-(1-imidazolyl)ethanol SKF 96365 HYDROCHLORIDE 2-HYDROXY-2-(4-METHOXYPHENYL)ETHYLAMINE HYDROCHLORIDE

1-[BETA-[3-(4-METHOXYPHENYL)PROPOXY]-4-METHOXYPHENETHYL]-1H-IMIDAZOLE HCL

1-(BETA-[3-(4-METHOXYPHENYL)PROPOXY]-4-METHOXYPHENETHYL)-1H-IMIDAZOLE HYDROCHLORIDE

1-[2-(4-METHOXYPHENYL)-2-[3-(4-METHOXYPHENYL)PROPOXY]ETHYL]-1H-IMIDAZOLE HYDROCHLORIDE

SK AND F 96365

SKF 96365

SKF 96365 HYDROCHLORIDE

SKF-96365, HCl

1-[β-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenethyl]-1h-imidazole hydrochloride

1-(2-(3-(4-methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole

SKF-96365, Hydrochloride - CAS 130495-35-1 - Calbiochem

SKF-96365;SKF 96365

CS-2170

1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]imidazole

1-(2-(3-(4-Methoxyphenyl)propoxy)-4-methoxyphenylethyl)-1H-imidazole hydrochloride

1H-Imidazole, 1-(2-(4-methoxyphenyl)-2-(3-(4-methoxyphenyl)propoxy)ethyl)-, monohydrochloride

SKF 96365 HCI

1-[2-(4-Methoxyphenyl)-2-[3-(4-methoxyphenyl)propoxy]ethyl]-1H-imidazole monohydrochloride

SKF-96365, HC

SKF 96365 hydrochlor

SKF 96365, TRP channel blocker

SKF-96365 hydrochloride, 10 mM in DMSO

SKF-96365 hydrochloride (SKF96365 hydrochloride)

130495-35-1

C22H26N2O3HCl

Voltage-gated Ion Channels

Ion Channels

Inhibitors and Activators

Cell Signaling and Neuroscience

Cell Biology

Calcium Channel Modulators

BioChemical

Calcium channel

Signalling