ChemicalBook > CAS DataBase List > Ethyl 4-amino-2-hydroxypyrimidine-5-carboxylate

Ethyl 4-amino-2-hydroxypyrimidine-5-carboxylate

Product Name: Ethyl 4-amino-2-hydroxypyrimidine-5-carboxylate
CAS No.: 20187-46-6
Chemical Name: Ethyl 4-amino-2-hydroxypyrimidine-5-carboxylate
Synonyms: 5-CARBETHOXYCYTOSINE;RSYY（Donepezil Hydrochloride)-12;2-hydroxy-4-amino-5-ethoxycarbonyl-pyrimidine;Ethyl4-Amino-2-hydroxy-5-pyrimidinecarboxylate;ethyl 6-amino-2-oxo-1H-pyrimidine-5-carboxylate;ETHYL-4-AMINO-2-HYDROXY PYRIMIDINE-5-CARBOXYLATE;Ethyl 4-aMino-2-hydroxypyriMidine-5-carboxyla...;ethyl 6-amino-2-oxo-1,2-dihydropyrimidine-5-carboxylate;4-AMino-2-hydroxy-pyriMidine-5-carboxylic acid ethyl ester;5-pyriMidinecarboxylic acid, 4-aMino-2-hydroxy-, ethyl ester
CBNumber: CB7756241
Molecular Formula: C7H9N3O3
Formula Weight: 183.16
MOL File: 20187-46-6.mol

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Ethyl 4-amino-2-hydroxypyrimidine-5-carboxylate Property

Melting point:: 276 °C (decomp)
Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 7.91±0.10(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S343374
Product name: 5-CARBETHOXYCYTOSINE
Purity: Aldrich
Packaging: 50mg
Price: $29.8
Updated: 2024/03/01

TRC

Product number: E678635
Product name: EthylCytosine-5-carboxylate
Packaging: 500mg
Price: $725
Updated: 2021/12/16

AK Scientific

Product number: W4263
Product name: Ethyl4-amino-2-hydroxypyrimidine-5-carboxylate
Packaging: 1g
Price: $487
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: NUC0001669
Product name: 6-AMINO-2-OXO-1,2-DIHYDRO-PYRIMIDINE-5-CARBOXYLIC ACID ETHYL ESTER
Purity: 95.00%
Packaging: 5MG
Price: $504.9
Updated: 2021/12/16

Labseeker

Product number: SC-23695
Product name: 2-hydroxy-4-amino-5-ethoxycarbonyl-pyrimidine
Purity: 95
Packaging: 1g
Price: $583
Updated: 2021/12/16

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Ethyl 4-amino-2-hydroxypyrimidine-5-carboxylate Chemical Properties,Usage,Production

Uses

Ethyl Cytosine-5-carboxylate is a reagent for the synthesis of cytidine-5-carboxylic acid, which are potential anticancer agents.

Synthesis

61679-83-2

20187-46-6

General procedure for the synthesis of ethyl 2-hydroxy-4-aminopyrimidine-5-carboxylate from RSSYY (lurasidone hydrochloride)-16: 400 ml of diethyl ether and 500 ml of tetrahydrofuran were added to a 2500 ml round bottomed flask, followed by the addition of 30 ml of sodium tert-butanol to synthesize intermediate 2. After stirring the mixture, 183 g (1 mol) of intermediate 1 and (0.1 mol) of sodium magnesium oxide nanopowder. The reaction mixture was heated to 75°C and maintained at this temperature for 2.5 hours. Upon completion of the reaction, it was quenched, cooled to room temperature and filtered to collect the yellow solid product. The resulting solid was dissolved in 500 ml of water with continuous stirring and gradual addition of water until the yellow solid was completely dissolved. The pH of the solution was adjusted to 6~7 with dilute hydrochloric acid (prepared from concentrated hydrochloric acid and water at a volume ratio of 1:3), at which time a white solid precipitated. The white solid was collected by filtration and washed with a small amount of acetone. After drying, Intermediate 2 was obtained as a white powdery solid with a yield of 168.4 g and 92%.

References

[1] Patent: CN103992278, 2016, B. Location in patent: Paragraph 0092; 0093
[2] Journal of the American Chemical Society, 1953, vol. 75, p. 671,674

Ethyl 4-amino-2-hydroxypyrimidine-5-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ethyl 4-amino-2-hydroxypyrimidine-5-carboxylate manufacturers

PNP Biotech Co. Ltd

Product: Ethyl 4-amino-2-hydroxy-5-pyrimidinecarboxylate 20187-46-6
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%
Supply Ability: Inquiry
Release date: 2023-07-12

Dideu Industries Group Limited

Product: Ethyl 4-amino-2-hydroxypyrimidine-5-carboxylate 20187-46-6
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-10

Career Henan Chemical Co

Product: Ethyl 4-amino-2-hydroxypyrimidine-5-carboxylate 20187-46-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-20

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Ethyl 4-amino-2-hydroxypyrimidine-5-carboxylate ISO 9001：2015 REACH

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20187-46-6

Heterocycle-Pyrimidine series

pyrimidine