Description References
ChemicalBook > CAS DataBase List > 1,3-Butanediol

1,3-Butanediol

Description References
Product Name
1,3-Butanediol
CAS No.
107-88-0
Chemical Name
1,3-Butanediol
Synonyms
BD;Butane-1,3-diol;1,3-BUTYLENE GLYCOL;1,3-Butandiol;(3S)-butane-1,3-diol;3-Butanediol;BUTAN-1,3-DIOL;(±)-butane-1,3-diol;1-Methyl-1,3-propanediol;butane-1,
CBNumber
CB7758265
Molecular Formula
C4H10O2
Formula Weight
90.12
MOL File
107-88-0.mol
More
Less

1,3-Butanediol Property

Melting point:
-54 °C
Boiling point:
203-204 °C(lit.)
Density 
1.005 g/mL at 25 °C(lit.)
vapor density 
3.1 (20 °C, vs air)
vapor pressure 
0.06 mm Hg ( 20 °C)
refractive index 
n20/D 1.44(lit.)
Flash point:
250 °F
storage temp. 
Store below +30°C.
solubility 
>500g/lMiscible
form 
Liquid
pka
14.83±0.20(Predicted)
Specific Gravity
1.004 – 1.007
color 
Clear colorless to yellow, may discolor to brown on storage
PH
6.1 (500g/l, H2O, 20℃)
Odor
odorless
PH Range
6 - 7 at 20 °C
explosive limit
1.9-12.6%(V)
Water Solubility 
SOLUBLE
Sensitive 
Hygroscopic
Merck 
14,1567
BRN 
1731276
Stability:
Stable. Flammable. Hygroscopic - protect from air and moisture. Incompatible with strong oxidizing agents.
LogP
-0.9 at 25℃
CAS DataBase Reference
107-88-0(CAS DataBase Reference)
NIST Chemistry Reference
1,3-Butanediol(107-88-0)
EPA Substance Registry System
1,3-Butylene glycol (107-88-0)
More
Less

Safety

Safety Statements 
24/25
WGK Germany 
1
RTECS 
EK0440000
F 
3
Autoignition Temperature
741 °F
TSCA 
Yes
HS Code 
29053920
Hazardous Substances Data
107-88-0(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 18610 mg/kg LD50 dermal Rabbit > 20000 mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B84785
Product name
(±)-1,3-Butanediol
Purity
ReagentPlus?,99.5%
Packaging
18L
Price
$1230
Updated
2024/03/01
Sigma-Aldrich
Product number
8.01964
Product name
1,3-Butanediol
Purity
for synthesis
Packaging
1L
Price
$51.4
Updated
2024/03/01
Sigma-Aldrich
Product number
8.01964
Product name
1,3-Butanediol
Purity
for synthesis
Packaging
25KG
Price
$491
Updated
2024/03/01
Sigma-Aldrich
Product number
8.01964
Product name
1,3-Butanediol
Purity
for synthesis
Packaging
200KG
Price
$3560
Updated
2024/03/01
Sigma-Aldrich
Product number
09068
Product name
(±)-1,3-Butanediol
Purity
analytical standard
Packaging
1ml
Price
$72
Updated
2024/03/01
More
Less

1,3-Butanediol Chemical Properties,Usage,Production

Description

1,3-Butanediol is an organic chemical which belongs to the family of secondary alcohols. At present, 1,3-butanediol is used mainly in surfactants, inks, solvents for natural and synthetic flavoring agents and serves as a co-monomer in manufacturing certain polyurethane and polyester resins. It can also serve as a humectant to prevent loss of moisture in cosmetics, particularly in hair sprays and setting lotions. Besides, 1,3-Butanediol is pharmaceutically involved in the production of colchicine derivatives as a anticancer agent and in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as a hypoglycaemic agent, which is effective for the treatment of diabetes.

References

https://en.wikipedia.org/wiki/1,3-Butanediol
https://www.trc-canada.com/product-detail/?B690010
http://www.hmdb.ca/metabolites/HMDB31320
https://www.alfa.com/zh-cn/catalog/A11684/

Chemical Properties

colourless liquid

Chemical Properties

Butylene glycol occurs as a clear, colorless, viscous liquid with a sweet flavor and bitter aftertaste.

Chemical Properties

1,3-Butylene glycol has a sweet flavor with bitter aftertaste and is odorless when pure.

Uses

(^+)-1,3-Butanediol acts as a co-monomer in the production of polyurethane and polyester resins. It is used as a humectant (to prevent loss of moisture) in cosmetics, especially in hair sprays and setting lotions. It is used in surfactants, inks, solvents for natural and synthetic flavorings. It is involved in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as euglycemic agents, which is used in the treatment of diabetes.

Uses

Its most extensive use is as an intermediate in the manufacture of polyester plasticisers and other chemical products. It finds some use as a solvent and humectant, a useful chemical intermediate. It has extensive application in the manufacture of structural materials for boats, custom mouldings, and sheets and boards for construction applications. 1,3-Butanediol imparts resistance to weathering plus flexibility and impact resistance. It is also used in the manufacture of saturated polyesters for polyurethane coatings, where the glycol imparts greater flexibility to the polyester molecule. 1,3-Butanediol is currently used in many personal care products.

Uses

1,3-Butanediol is used in the synthesis of colchicine derivatives as anticancer agents. Also used in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as euglycem ic agents in the treatment of diabetes.

Preparation

From formaldehyde and propylene via pressure and a catalyst.

Production Methods

Butylene glycol is prepared by catalytic hydrogenation of aldol using Raney nickel.

Definition

ChEBI: A butanediol compound having two hydroxy groups in the 1- and 3-positions.

Aroma threshold values

Detection: 70 to 100 ppm

General Description

(±)-1,3-Butanediol (BD) is a 1,3-diol. Its vapor pressure upto 270kPa, liquid-phase densities over a temperature range, two-phase (liquid + vapor) heat capacities, critical temperature and critical density have been determined. The obtained data was employed to derive various thermophysical properties.

Flammability and Explosibility

Not classified

Pharmaceutical Applications

Butylene glycol is used as a solvent and cosolvent for injectables. It is used in topical ointments, creams, and lotions, and it is also used as a vehicle in transdermal patches. Butylene glycol is a good solvent for many pharmaceuticals, especially estrogenic substances.
In an oil-in-water emulsion, butylene glycol exerts its best antimicrobial effects at ～8% concentration. Higher concentrations above 16.7% are required to inhibit fungal growth.

Contact allergens

This dihydric alcohol is used for its humectant and preservative potentiator properties in cosmetics, topical medicaments and polyurethane, polyester, cellophane, and cigarettes. It has similar properties, but is less irritant than propylene glycol. Contact allergies seem to be rare.

Safety Profile

Mdly toxic by ingestion and subcutaneous routes. A skin and eye irritant. See also ETHYLENE GLYCOL. Experimental reproductive effects. Combustible when exposed to heat or flame. Incompatible with oxidizing materials. To fight fire, use foam, alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.

Safety

Butylene glycol is used in a wide variety of cosmetic formulations and is generally regarded as a relatively nontoxic material. It is mildly toxic by oral and subcutaneous routes.
In topical preparations, butylene glycol is regarded as minimally irritant. Butylene glycol can cause allergic contact dermatitis, with local sensitivity reported in patch tests. Some local irritation is produced on eye contact.
LD50 (guinea pig, oral): 11.0 g/kg
LD50 (mouse, oral): 12.98 g/kg
LD50 (rat, oral): 18.61 g/kg
LD50 (rat, SC): 20.0 g/kg

Carcinogenicity

There were no tumors found in the 2-year feeding studies on dogs and rats . Thus, it appears that 1,3-butanediol is not carcinogenic.

storage

Butylene glycol is hygroscopic and should be stored in a well-closed container in a cool, dry, well-ventilated place. When heated to decomposition, butylene glycol emits acrid smoke and irritating fumes.

Incompatibilities

Butylene glycol is incompatible with oxidizing reagents.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (transdermal patches). Included in licensed medicines in the UK (topical gel patches/medicated plasters).

1,3-Butanediol Preparation Products And Raw materials

Raw materials

PROPYLENE Butyraldehyde ALDOL

Preparation Products

More
Less

1,3-Butanediol Suppliers

Americas 1 Australia 2 Austria 1 Belgium 4 Brazil 1 Canada 3 CHINA 397 Europe 5 France 4 Germany 30 India 33 Italy 1 Japan 17 Mexico 1 Philippines 1 Slovakia 1 South Korea 2 Spain 2 Switzerland 3 The Netherlands 4 Ukraine 2 United Kingdom 11 United States 70 Global 596
JIANGSU BSECHEM CHEMICAL TECHNOLOGY Co., Ltd
Tel
15651337098
Email
15651337098@163.com
Country
China
ProdList
1034
Advantage
58
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
18521735133 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25015
Advantage
65
Nantong Runfeng Petrochemical Co., Ltd
Tel
0513-66017690 13912270238
Fax
0513-55085866
Email
2143087160@qq.com
Country
China
ProdList
3700
Advantage
58
Zhejiang Invertin Biotechnology Co.,Ltd.td.
Tel
0572-2165030 18017878053
Fax
QQ:1169435659
Email
invertin@yeah.net
Country
China
ProdList
44
Advantage
58
Wohui Biochemical Technology (Huzhou) Co., LTD
Tel
17369573755
Email
sunxiaolei6016@dingtalk.com
Country
China
ProdList
40
Advantage
58
Beijing OKA biological technology co., LTD
Tel
010-62971590 18548936886
Fax
010-62340519
Email
3462612863@qq.com
Country
China
ProdList
6912
Advantage
58
Shandong Qianfanshun Chemical Co., Ltd
Tel
15610119970
Email
1542002666@qq.com
Country
China
ProdList
396
Advantage
58
shandongxinhenghuagongyouxiangongsi
Tel
1526-9160602 15269160602
Email
15269160602@163.com
Country
China
ProdList
240
Advantage
58
shandongxinheng
Tel
15269160605
Email
15269160605@163.com
Country
China
ProdList
239
Advantage
58
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30132
Advantage
84
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24539
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44751
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12458
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9984
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9551
Advantage
66
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696;
Email
info@hanhongsci.com
Country
China
ProdList
42982
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32344
Advantage
50
Shandong Xiya Chemical Co., Ltd
Tel
13355009207 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18739
Advantage
57
BEST-REAGENT
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11726
Advantage
57
China Langchem Inc.
Tel
0086-21-58956006
Fax
0086-21-58956100
Country
China
ProdList
7815
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14443
Advantage
57
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
Country
China
ProdList
9823
Advantage
79
Maya High Purity Chemicals
Tel
+86 (573) 82222445 (0)18006601000 452520369
Fax
+86 (573) 82222643
Email
sales@maya-r.com
Country
China
ProdList
11714
Advantage
57
Beijing Taiya Jie Technology Development Co., Ltd.
Tel
021-33690831-8001 13552411790
Fax
021-33690831
Email
postmaster@tyjchem.cn
Country
China
ProdList
1542
Advantage
55
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847 13636370518
Fax
021-55068248
Email
shyysw007@163.com
Country
China
ProdList
4941
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9725
Advantage
55
Shanghai civi chemical technology co.,Ltd
Tel
86-21-34053660
Fax
86-21-34053661
Email
sale@labgogo.com
Country
China
ProdList
9872
Advantage
52
Beijing Yisiyan Technology Research Center
Tel
010-56645598 13366904824
Fax
01062230033
Email
bjkaida@163.com
Country
China
ProdList
1666
Advantage
59
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17779
Advantage
75
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12338
Advantage
58
Shanghai Jian Chao Chemical Technology Co., Ltd.
Tel
021-50430803 18017383231
Fax
qq：2817624287
Email
983544897@qq.com
Country
China
ProdList
9352
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22519
Advantage
55
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9552
Advantage
55
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4576
Advantage
55
Chengdu AstaTech Trading Co., Ltd./AstaTech (Chengdu) Pharma. Co., Ltd.
Tel
+86-28-85122536 85324413
Fax
+86-28-85326443
Email
market@astatech.cn
Country
China
ProdList
8033
Advantage
55
TargetMol Chemicals Inc.
Tel
021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7934
Advantage
58
Shanghai BeiZhuo Biotech Co., Ltd.
Tel
021-61119791,13386096464
Fax
021-50190009
Email
bzswkf@foxmail.com
Country
China
ProdList
3924
Advantage
50
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3123
Advantage
55
Shanghai Meishui Chemical Technology Co., Ltd
Tel
021-60549325 18616193163
Fax
021-33250306
Country
China
ProdList
4528
Advantage
56
Bide Pharmatech Ltd.
Tel
400-1647117 15221909166
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41438
Advantage
60
RiZhao LiDeShi Chemical Co., Ltd.
Tel
010-51268198
Fax
010-63833209
Email
leadershipchem@126.com
Country
China
ProdList
2549
Advantage
58
Zhengzhou ALFA Chemical Co., Ltd.
Tel
0371-53732842 15981811963
Fax
0371-86239377
Email
1758257485@qq.com
Country
China
ProdList
951
Advantage
56
Mei Lan Industrial (Shanghai) Co., Ltd.
Tel
021-58958189
Fax
021-58957967
Email
wouchina@126.com
Country
China
ProdList
2671
Advantage
55
ChemStrong Scientific Co.,Ltd
Tel
0755-0755-66853366 13670046396
Fax
0755-28363542
Email
sales@chem-strong.com
Country
China
ProdList
17982
Advantage
56
Shanghai ideal Industrial Co., Ltd.
Tel
021-58957966 18930537195
Fax
021-60899437
Email
wouchina@126.com
Country
China
ProdList
3033
Advantage
58
Sichuan Wei Keqi Biological Technology Co., Ltd.
Tel
028-81700200 18116577057
Fax
028-81705658
Email
3003855609@qq.com
Country
China
ProdList
7892
Advantage
56
Chengdu HuaXia Chemical Reagent Co. Ltd
Tel
400-1166-196 13458535857
Fax
QQ：800101999
Email
cdhxsj@163.com
Country
China
ProdList
13358
Advantage
58
GuangTuo Chemical (Shanghai) Co., Ltd.
Tel
021-60899189-8001 18918189673
Fax
021-60899304
Email
gtchem@126.com
Country
China
ProdList
2661
Advantage
58
More
Less

View Lastest Price from 1,3-Butanediol manufacturers

Hebei Yime New Material Technology Co., Ltd.
Product
1,3-Butanediol 107-88-0
Price
US $4.00/KG
Min. Order
1000KG
Purity
99%
Supply Ability
1000kg/day
Release date
2023-11-15
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
1,3-butylene glycol 107-88-0
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-04-22
Hebei Saisier Technology Co., LTD
Product
1,3-Butanediol 107-88-0
Price
US $6.00/KG
Min. Order
1KG
Purity
More than 99%
Supply Ability
2000KG/Month
Release date
2024-04-15

107-88-0, 1,3-ButanediolRelated Search:

Ethylene glycol diacetate Diethylene glycol Dipropylene glycol Triclosan 2,3-Butanediol 2-Butoxyethyl acetate 3-Diethylaminophenol 1-BUTENE 2-Butoxyethanol 1-Hydroxyethylidene-1,1-diphosphonic acid 2-Methyl-2,4-pentanediol Ethylene glycol 1,4-Butanediol 1,3-Dihydroxyacetone 2-Butyne-1,4-diol Chrysin Butylated Hydroxytoluene PROPYLENE GLYCOL

  • (±)-butane-1,3-diol
  • 1,3-Butandiol
  • Methyltrimethylene
  • Methyltrimethylene glycol
  • methyltrimethyleneglycol
  • 1-METHYLTRIMETHYLENE GLYCOL
  • 1,3-DIHYDROXYBUTANE
  • (+/-)-1,3-BUTANEDIOL
  • 1,3-BUTANEDIOL
  • 1,3-BUTYLENE GLYCOL
  • 1,3-BUTANEDIOL, REAGENTPLUS, 99%
  • 1,3-BUTANEDIOL, ANHYDROUS, 99+%
  • (q) -1,3-Butanediol 4 M Solution
  • 1,3-BUTANEDIOL, 99+%
  • 1,3Butanediol,98%
  • 1,3-butan-diol (=1,3-butylene glycol)
  • (n)-1,3-butanediol
  • 1,3-butanediole
  • 1,3-butylenglycol
  • RS-1,3-BUTANEDIOL
  • BUTAN-1,3-DIOL
  • BUTYLENGLYKOL-1,3
  • 1,3-BUTANEDIOL GR
  • 1,3-BUTANEDIOL CP
  • 1,3-BUTYLENE GLYCOL FCC
  • Daicel 1,3-Butylene Glycol
  • (+/-)-1,3-Butanediol ReagentPlus(R), 99.5%
  • (+/-)-1,3-Butanediol Vetec(TM) reagent grade, 98%
  • B-BUTYLENE GLYCOL
  • (3S)-butane-1,3-diol
  • 1,3-Butandiol Msynthplus
  • 1,3-Butanediol, 99%, SuperDry, water≤30 ppm, J&KSeal
  • 3-Butanediol
  • 1,3-Butanodiol
  • 1,3-butylene
  • 1,3-Butylenglykol
  • 1,3-Dihydroxybotane
  • 1,3-Butaneiol
  • 1-Methyl-1,3-propanediol
  • BD
  • beta-Butylene glycol
  • beta-butyleneglycol
  • butane-1,
  • butane-1,3-
  • Butane-1,3-diol
  • 1,3-Butanediol [for BiocheMical Research]
  • [for BiocheMical Research]
  • 1,3-Butanediol&nbsp
  • (§1)-1,3-Butanediol, 99%, pure
  • (§1)-1,3-Butanediol, pure, 99%
  • 1,3-BUTANEDIOL FOR SYNTHESIS
  • 1,3-Butylene Glycol 1,3-Dihydroxybutane
  • ()-1,3-Butanediol, 99%, pure
  • 1,3-Butanediol, 99%, SpcDry, Water≤50 ppM (by K.F.), SpcSeal
  • 1,3-Butanediol, 99%, SpcDry, with Molecular sieves, Water≤50 ppM (by K.F.), SpcSeal
  • (±)-1,3-Butanediol 4 M solution
  • (±)-1,3-Butanediol solution
  • Additive Screening Solution 03/Fluka kit no 78374