Description References
ChemicalBook > CAS DataBase List > 1,3-Butanediol

1,3-Butanediol

Description References
Product Name
1,3-Butanediol
CAS No.
107-88-0
Chemical Name
1,3-Butanediol
Synonyms
BD;Butane-1,3-diol;1,3-BUTYLENE GLYCOL;1,3-Butandiol;(3S)-butane-1,3-diol;3-Butanediol;BUTAN-1,3-DIOL;(±)-butane-1,3-diol;1-Methyl-1,3-propanediol;butane-1,
CBNumber
CB7758265
Molecular Formula
C4H10O2
Formula Weight
90.12
MOL File
107-88-0.mol
More
Less

1,3-Butanediol Property

Melting point:
-54 °C
Boiling point:
203-204 °C(lit.)
Density 
1.005 g/mL at 25 °C(lit.)
vapor density 
3.1 (20 °C, vs air)
vapor pressure 
0.06 mm Hg ( 20 °C)
refractive index 
n20/D 1.44(lit.)
Flash point:
250 °F
storage temp. 
Store below +30°C.
solubility 
>500g/lMiscible
form 
Liquid
pka
14.83±0.20(Predicted)
Specific Gravity
1.004 – 1.007
color 
Clear colorless to yellow, may discolor to brown on storage
PH
6.1 (500g/l, H2O, 20℃)
Odor
odorless
PH Range
6 - 7 at 20 °C
explosive limit
1.9-12.6%(V)
Water Solubility 
SOLUBLE
Sensitive 
Hygroscopic
Merck 
14,1567
BRN 
1731276
Stability:
Stable. Flammable. Hygroscopic - protect from air and moisture. Incompatible with strong oxidizing agents.
LogP
-0.9 at 25℃
CAS DataBase Reference
107-88-0(CAS DataBase Reference)
NIST Chemistry Reference
1,3-Butanediol(107-88-0)
EPA Substance Registry System
1,3-Butylene glycol (107-88-0)
More
Less

Safety

Safety Statements 
24/25
WGK Germany 
1
RTECS 
EK0440000
F 
3
Autoignition Temperature
741 °F
TSCA 
Yes
HS Code 
29053920
Hazardous Substances Data
107-88-0(Hazardous Substances Data)
Toxicity
LD50 orally in Rabbit: 18610 mg/kg LD50 dermal Rabbit > 20000 mg/kg
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PHR2896
Product name
Butane-1,3-diol
Purity
pharmaceutical secondary standard, certified reference material
Packaging
1.2ML
Price
$152
Updated
2025/07/31
Sigma-Aldrich
Product number
B84785
Product name
(±)-1,3-Butanediol
Purity
ReagentPlus?,99.5%
Packaging
18L
Price
$1280
Updated
2025/07/31
Sigma-Aldrich
Product number
09068
Product name
(±)-1,3-Butanediol
Purity
analytical standard
Packaging
1ml
Price
$74.2
Updated
2025/07/31
Sigma-Aldrich
Product number
09068
Product name
(±)-1,3-Butanediol
Purity
analytical standard
Packaging
5ml
Price
$291
Updated
2025/07/31
Sigma-Aldrich
Product number
8.01964
Product name
1,3-Butanediol
Purity
for synthesis
Packaging
1L
Price
$51.4
Updated
2024/03/01
More
Less

1,3-Butanediol Chemical Properties,Usage,Production

Description

1,3-Butanediol is an organic chemical which belongs to the family of secondary alcohols. At present, 1,3-butanediol is used mainly in surfactants, inks, solvents for natural and synthetic flavoring agents and serves as a co-monomer in manufacturing certain polyurethane and polyester resins. It can also serve as a humectant to prevent loss of moisture in cosmetics, particularly in hair sprays and setting lotions. Besides, 1,3-Butanediol is pharmaceutically involved in the production of colchicine derivatives as a anticancer agent and in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as a hypoglycaemic agent, which is effective for the treatment of diabetes.

References

https://en.wikipedia.org/wiki/1,3-Butanediol
https://www.trc-canada.com/product-detail/?B690010
http://www.hmdb.ca/metabolites/HMDB31320
https://www.alfa.com/zh-cn/catalog/A11684/

Chemical Properties

1,3-Butanediol is a colorless oily liquid. Sp.Gr. 1.00. B.P. 207℃. Miscible with water, soluble in alcohol and many perfume and flavor materials, but poorly soluble in hydrocarbons (terpenes, etc.). 1,3-Butylene glycol has a sweet flavor with bitter aftertaste and is odorless when pure.

Chemical Properties

colourless liquid

Chemical Properties

Butylene glycol occurs as a clear, colorless, viscous liquid with a sweet flavor and bitter aftertaste.

Uses

(^+)-1,3-Butanediol acts as a co-monomer in the production of polyurethane and polyester resins. It is used as a humectant (to prevent loss of moisture) in cosmetics, especially in hair sprays and setting lotions. It is used in surfactants, inks, solvents for natural and synthetic flavorings. It is involved in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as euglycemic agents, which is used in the treatment of diabetes.

Uses

Its most extensive use is as an intermediate in the manufacture of polyester plasticisers and other chemical products. It finds some use as a solvent and humectant, a useful chemical intermediate. It has extensive application in the manufacture of structural materials for boats, custom mouldings, and sheets and boards for construction applications. 1,3-Butanediol imparts resistance to weathering plus flexibility and impact resistance. It is also used in the manufacture of saturated polyesters for polyurethane coatings, where the glycol imparts greater flexibility to the polyester molecule. 1,3-Butanediol is currently used in many personal care products.

Uses

1,3-Butanediol is used in the synthesis of colchicine derivatives as anticancer agents. Also used in the synthesis of dual peroxisome proliferator-activated gamma and delta agonists acting as euglycem ic agents in the treatment of diabetes.

Preparation

From formaldehyde and propylene via pressure and a catalyst.

Production Methods

Butylene glycol is prepared by catalytic hydrogenation of aldol using Raney nickel.

Definition

ChEBI: A butanediol compound having two hydroxy groups in the 1- and 3-positions.

Aroma threshold values

Detection: 70 to 100 ppm

General Description

(±)-1,3-Butanediol (BD) is a 1,3-diol. Its vapor pressure upto 270kPa, liquid-phase densities over a temperature range, two-phase (liquid + vapor) heat capacities, critical temperature and critical density have been determined. The obtained data was employed to derive various thermophysical properties.

Flammability and Explosibility

Not classified

Pharmaceutical Applications

Butylene glycol is used as a solvent and cosolvent for injectables. It is used in topical ointments, creams, and lotions, and it is also used as a vehicle in transdermal patches. Butylene glycol is a good solvent for many pharmaceuticals, especially estrogenic substances.
In an oil-in-water emulsion, butylene glycol exerts its best antimicrobial effects at ～8% concentration. Higher concentrations above 16.7% are required to inhibit fungal growth.

Contact allergens

This dihydric alcohol is used for its humectant and preservative potentiator properties in cosmetics, topical medicaments and polyurethane, polyester, cellophane, and cigarettes. It has similar properties, but is less irritant than propylene glycol. Contact allergies seem to be rare.

Side effects

1,3-Butanediol is commonly used as a solvent in food flavourings and is mildly toxic by oral and subcutaneous routes, with possible side effects including severe respiratory problems, coma, amnesia, belligerence, confusion, agitation, vomiting, seizures and very slow heartbeat. People who use butylene glycol on a regular basis and then stop using it may also experience withdrawal symptoms such as sleep problems (insomnia), tremors and anxiety.

Safety Profile

Mdly toxic by ingestion and subcutaneous routes. A skin and eye irritant. See also ETHYLENE GLYCOL. Experimental reproductive effects. Combustible when exposed to heat or flame. Incompatible with oxidizing materials. To fight fire, use foam, alcohol foam, CO2, dry chemical. When heated to decomposition it emits acrid smoke and irritating fumes.

Safety

Butylene glycol is used in a wide variety of cosmetic formulations and is generally regarded as a relatively nontoxic material. It is mildly toxic by oral and subcutaneous routes.
In topical preparations, butylene glycol is regarded as minimally irritant. Butylene glycol can cause allergic contact dermatitis, with local sensitivity reported in patch tests. Some local irritation is produced on eye contact.
LD50 (guinea pig, oral): 11.0 g/kg
LD50 (mouse, oral): 12.98 g/kg
LD50 (rat, oral): 18.61 g/kg
LD50 (rat, SC): 20.0 g/kg

Carcinogenicity

There were no tumors found in the 2-year feeding studies on dogs and rats . Thus, it appears that 1,3-butanediol is not carcinogenic.

storage

Butylene glycol is hygroscopic and should be stored in a well-closed container in a cool, dry, well-ventilated place. When heated to decomposition, butylene glycol emits acrid smoke and irritating fumes.

Incompatibilities

Butylene glycol is incompatible with oxidizing reagents.

Regulatory Status

GRAS listed. Included in the FDA Inactive Ingredients Database (transdermal patches). Included in licensed medicines in the UK (topical gel patches/medicated plasters).

1,3-Butanediol Preparation Products And Raw materials

Raw materials

PROPYLENE Butyraldehyde ALDOL

Preparation Products

More
Less

1,3-Butanediol Suppliers

Americas 1 Australia 2 Austria 1 Belgium 4 Brazil 1 Canada 3 China 491 Europe 5 France 4 Germany 30 India 33 Italy 1 Japan 17 Mexico 1 Philippines 1 Slovakia 1 South Korea 2 Spain 2 Switzerland 3 The Netherlands 4 Ukraine 2 United Kingdom 11 United States 70 Global 690
Alfa Chemistry
Tel
+1-5166625404;
Fax
1-516-927-0118
Email
Info@alfa-chemistry.com
Country
United States
ProdList
20405
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Alfa Chemistry
Tel
Email
info@alfa-chemistry.com
Country
United States
ProdList
2344
Advantage
58
Aston Chemical
Tel
13000000000
Email
sales@astonchem.com
Country
United States
ProdList
1634
Advantage
58
CarboMer, Inc.
Tel
--
Fax
--
Email
sales@carbomer.com
Country
United States
ProdList
4026
Advantage
67
AccuStandard Inc
Tel
--
Fax
--
Email
info@bester.nl
Country
United States
ProdList
5300
Advantage
76
Bruchem, Inc.
Tel
--
Fax
--
Email
sales@bruchem.com
Country
United States
ProdList
576
Advantage
58
DAICEL ChemTech, Inc. (part of DAICEL Corporation)
Tel
--
Fax
--
Email
inquiry@us.daicel.com
Country
United States
ProdList
33
Advantage
58
AXO Chemical
Tel
--
Fax
--
Email
info@axochemical.com
Country
United States
ProdList
73
Advantage
58
Redox Scientific
Tel
--
Fax
--
Email
info@redoxsci.com
Country
United States
ProdList
2380
Advantage
58
Tide Intl. Inc.
Tel
--
Fax
--
Email
johnliu@tideintl.com
Country
United States
ProdList
21
Advantage
58
Advanced Synthesis S.A.
Tel
--
Fax
--
Country
United States
ProdList
249
Advantage
58
JEEN International Corporation
Tel
--
Fax
--
Email
info@jeen.com
Country
United States
ProdList
47
Advantage
58
Combi-Blocks, Inc.
Tel
--
Fax
--
Email
les@combi-blocks.com
Country
United States
ProdList
2555
Advantage
58
Parchem Fine & Specialty Chemicals
Tel
--
Fax
--
Email
info@parchem.com
Country
United States
ProdList
1031
Advantage
58
TCI America, Inc. (Tokyo Chemical Industry Co., Ltd.)
Tel
--
Fax
--
Email
.Crew@tcichemicals.com
Country
United States
ProdList
3164
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
OXEA Corporation
Tel
--
Fax
--
Country
United States
ProdList
30
Advantage
58
Pride Chemical Solutions, Inc.
Tel
--
Fax
--
Email
info@pridesol.com
Country
United States
ProdList
114
Advantage
58
2A Biotech USA
Tel
--
Fax
--
Email
info@2abiotech.com
Country
United States
ProdList
1785
Advantage
58
Gulf Bayport Chemicals L.P.
Tel
--
Fax
--
Country
United States
ProdList
4
Advantage
58
Grant Industries, Inc.,
Tel
--
Fax
--
Country
United States
ProdList
2
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
Spectrum Chemical Mfg. Corp.
Tel
--
Fax
--
Email
marketing@spectrumchemical.com
Country
United States
ProdList
3113
Advantage
60
Coast Chemical Inc.
Tel
--
Fax
--
Email
info@coastsouthwest.com
Country
United States
ProdList
7
Advantage
58
VWR International, LLC.
Tel
--
Fax
--
Email
@sargentwelch.com
Country
United States
ProdList
6262
Advantage
58
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
Norman, Fox & Co.
Tel
--
Fax
--
Email
info@norfoxchem.com
Country
United States
ProdList
30
Advantage
58
Penta International Corporation
Tel
--
Fax
--
Email
lisaa@pentamfg.com
Country
United States
ProdList
5042
Advantage
58
ECSA Chemicals
Tel
--
Fax
--
Email
marketing@ecsa.ch
Country
United States
ProdList
1735
Advantage
58
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
MedChemExpress
Tel
--
Fax
--
Email
sales@medchemexpress.com
Country
United States
ProdList
6398
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Sachem, Inc.
Tel
--
Fax
--
Country
United States
ProdList
95
Advantage
76
Chemstock Inc.
Tel
--
Fax
--
Email
mail@chemstock.com
Country
United States
ProdList
575
Advantage
34
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
Global ChemSources, Inc.
Tel
--
Fax
--
Email
sales@globalchemsources.com
Country
United States
ProdList
132
Advantage
30
Penta Manufacturing Company
Tel
--
Fax
--
Email
sales@pentamfg.com
Country
United States
ProdList
5076
Advantage
65
Pfaltz & Bauer, Inc.
Tel
--
Fax
--
Email
sales@pfaltzandbauer.com
Country
United States
ProdList
6828
Advantage
72
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
DuPont Specialty Colorants & Additives
Tel
--
Fax
--
Country
United States
ProdList
1186
Advantage
87
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
Dow Chemical Company
Tel
--
Fax
--
Email
dowcig@dow.com
Country
United States
ProdList
770
Advantage
90
More
Less

View Lastest Price from 1,3-Butanediol manufacturers

Anhuyan (Hainan) Biotechnology Co., LTD
Product
1,3-Butanediol 107-88-0
Price
US $0.00-0.00/g
Min. Order
0.1g
Purity
99%
Supply Ability
2200000t
Release date
2025-06-11
Hebei Chuanghai Biotechnology Co,.LTD
Product
1,3-Butanediol 107-88-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50 ton
Release date
2025-06-10
Shaanxi Dideu Medichem Co. Ltd
Product
1,3-Butanediol 107-88-0
Price
US $300.00-13.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20000KG
Release date
2025-04-29

107-88-0, 1,3-ButanediolRelated Search:

3-Diethylaminophenol 2-Butyne-1,4-diol Ethylene glycol diacetate Diethylene glycol Dipropylene glycol Triclosan 2,3-Butanediol 2-Butoxyethyl acetate 2-Butoxyethanol 1-Hydroxyethylidene-1,1-diphosphonic acid 2-Methyl-2,4-pentanediol Ethylene glycol 1,4-Butanediol 1,3-Dihydroxyacetone Chrysin Butylated Hydroxytoluene 1-BUTENE PROPYLENE GLYCOL

  • (±)-butane-1,3-diol
  • 1,3-Butandiol
  • Methyltrimethylene
  • Methyltrimethylene glycol
  • methyltrimethyleneglycol
  • 1-METHYLTRIMETHYLENE GLYCOL
  • 1,3-DIHYDROXYBUTANE
  • 1,3-BUTANEDIOL
  • 1,3-BUTYLENE GLYCOL
  • 1,3-BUTANEDIOL, REAGENTPLUS, 99%
  • 1,3-BUTANEDIOL, ANHYDROUS, 99+%
  • (q) -1,3-Butanediol 4 M Solution
  • 1,3-BUTANEDIOL, 99+%
  • 1,3Butanediol,98%
  • 1,3-butan-diol (=1,3-butylene glycol)
  • (n)-1,3-butanediol
  • 1,3-butanediole
  • 1,3-butylenglycol
  • RS-1,3-BUTANEDIOL
  • BUTAN-1,3-DIOL
  • BUTYLENGLYKOL-1,3
  • 1,3-BUTANEDIOL GR
  • 1,3-BUTANEDIOL CP
  • 1,3-BUTYLENE GLYCOL FCC
  • Daicel 1,3-Butylene Glycol
  • (+/-)-1,3-Butanediol ReagentPlus(R), 99.5%
  • (+/-)-1,3-Butanediol Vetec(TM) reagent grade, 98%
  • B-BUTYLENE GLYCOL
  • (3S)-butane-1,3-diol
  • 1,3-Butandiol Msynthplus
  • 1,3-Butanediol, 99%, SuperDry, water≤30 ppm, J&KSeal
  • 3-Butanediol
  • 1,3-Butanodiol
  • 1,3-butylene
  • 1,3-Butylenglykol
  • 1,3-Dihydroxybotane
  • 1,3-Butaneiol
  • 1-Methyl-1,3-propanediol
  • BD
  • beta-Butylene glycol
  • beta-butyleneglycol
  • butane-1,
  • butane-1,3-
  • Butane-1,3-diol
  • 1,3-Butanediol [for BiocheMical Research]
  • [for BiocheMical Research]
  • 1,3-Butanediol&nbsp
  • (§1)-1,3-Butanediol, 99%, pure
  • (§1)-1,3-Butanediol, pure, 99%
  • 1,3-BUTANEDIOL FOR SYNTHESIS
  • 1,3-Butylene Glycol 1,3-Dihydroxybutane
  • ()-1,3-Butanediol, 99%, pure
  • 1,3-Butanediol, 99%, SpcDry, Water≤50 ppM (by K.F.), SpcSeal
  • 1,3-Butanediol, 99%, SpcDry, with Molecular sieves, Water≤50 ppM (by K.F.), SpcSeal
  • (±)-1,3-Butanediol 4 M solution
  • (±)-1,3-Butanediol solution
  • Additive Screening Solution 03/Fluka kit no 78374
  • 1,3-Butylene Glycol(cosmetic grade)