ChemicalBook > CAS DataBase List > 2-Phenoxyethyl chloride

2-Phenoxyethyl chloride

Product Name
2-Phenoxyethyl chloride
CAS No.
622-86-6
Chemical Name
2-Phenoxyethyl chloride
Synonyms
NSC 1073;-Chlorophenetole;B-CHLOROPHENETOLE;á-chlorophenetole;β-chlorophenetole;?-chlorophenetole;PHENOXYETHYLCHLORIDE;OMEGA-CHLOROPHENETOL;BETA-CHLOROPHENETOLE;2-Phenoxyethyl chlor
CBNumber
CB7775967
Molecular Formula
C8H9ClO
Formula Weight
156.61
MOL File
622-86-6.mol
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2-Phenoxyethyl chloride Property

Melting point:
28°C
Boiling point:
97-98 °C15 mm Hg(lit.)
Density 
1.129 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.534(lit.)
Flash point:
213 °F
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform, Ethyl Acetate
form 
Solid
color 
Pale Yellow Oil to Low Melting Colorless
BRN 
971048
CAS DataBase Reference
622-86-6(CAS DataBase Reference)
NIST Chemistry Reference
Benzene, (2-chloroethoxy)-(622-86-6)
EPA Substance Registry System
(2-Chloroethoxy)benzene (622-86-6)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
RIDADR 
UN 3265
WGK Germany 
3
10-21
TSCA 
Yes
HS Code 
29093090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
114278
Product name
(2-Chloroethoxy)benzene
Purity
98%
Packaging
10ml
Price
$69.8
Updated
2025/07/31
TCI Chemical
Product number
C0240
Product name
beta-Chlorophenetole
Purity
>95.0%(GC)
Packaging
25mL
Price
$83
Updated
2025/07/31
TCI Chemical
Product number
C0240
Product name
beta-Chlorophenetole
Purity
>95.0%(GC)
Packaging
500mL
Price
$817
Updated
2025/07/31
TRC
Product number
P319625
Product name
Phenyl2-ChloroethylEther
Packaging
100g
Price
$325
Updated
2021/12/16
Usbiological
Product number
286791
Product name
Phenyl 2-chloroethyl ether
Packaging
250g
Price
$456
Updated
2021/12/16
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2-Phenoxyethyl chloride Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Oil

Uses

Phenyl 2-Chloroethyl Ether (cas# 622-86-6) is a compound useful in organic synthesis.

Uses

(2-Chloroethoxy)benzene is used in the coupling reaction of benzaldehyde, cinnamyltrimethylsilane and anisole in the synthesis of pseudo-symmetrical tamoxifen derivatives.

Synthesis

122-99-6

622-86-6

At room temperature, 2.5 mL of N-methylpyrrolidone (NMP), 1.38 g (10 mmol) of 2-phenoxyethanol and 1.5 mL (11 mmol) of benzenesulfonyl chloride were added to the reaction flask. The mixture was stirred well and then the reaction was continuously stirred at 100 °C for 30 min. Upon completion of the reaction, the reaction mixture was cooled to room temperature and subsequently extracted by adding 30 mL of dichloromethane and 30 mL of water. The organic layer was separated and washed with saturated brine and dried over anhydrous sodium sulfate. Dichloromethane was removed by evaporation under reduced pressure to give the crude product. The crude product was purified by column chromatography to give 1.52 g of 2-chlorophenetole in colorless liquid form in 96.8% yield.

References

[1] Patent: CN106187674, 2016, A. Location in patent: Paragraph 0017; 0018
[2] Patent: US2016/347717, 2016, A1. Location in patent: Paragraph 0232; 0233
[3] Patent: US5527816, 1996, A
[4] Chemical Research in Toxicology, 2000, vol. 13, # 1, p. 53 - 62
[5] Patent: CN106146450, 2016, A. Location in patent: Paragraph 0132; 0133; 0134

2-Phenoxyethyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Phenoxyethyl chloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Phenoxyethyl chloride 622-86-6
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%min
Supply Ability
10 tons
Release date
2021-07-20
Career Henan Chemical Co
Product
2-Phenoxyethyl chloride 622-86-6
Price
US $1.00/KG
Min. Order
1KG
Purity
≥98%
Supply Ability
g/kg/Ton
Release date
2019-12-25

622-86-6, 2-Phenoxyethyl chlorideRelated Search:


  • (2-chloroethoxy)-benzen
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  • benzene,(2-chloroethoxy)-
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  • 2-(CHLOROETHYOXY)BENZENE
  • (2-CHLOROETHOXY)BENZENE
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  • β-Chlorophenetole &gt
  • Benzene, chloroethoxy-
  • β-chlorophenetole
  • ?-chlorophenetole
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  • 622-86-6
  • C6H5OCH22Cl
  • C6H5OCH2CH2Cl
  • ClC6H4OC2H5
  • Building Blocks
  • Organic Building Blocks
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