2-Phenoxyethyl chloride
- Product Name
- 2-Phenoxyethyl chloride
- CAS No.
- 622-86-6
- Chemical Name
- 2-Phenoxyethyl chloride
- Synonyms
- NSC 1073;-Chlorophenetole;B-CHLOROPHENETOLE;á-chlorophenetole;β-chlorophenetole;?-chlorophenetole;PHENOXYETHYLCHLORIDE;OMEGA-CHLOROPHENETOL;BETA-CHLOROPHENETOLE;2-Phenoxyethyl chlor
- CBNumber
- CB7775967
- Molecular Formula
- C8H9ClO
- Formula Weight
- 156.61
- MOL File
- 622-86-6.mol
2-Phenoxyethyl chloride Property
- Melting point:
- 28°C
- Boiling point:
- 97-98 °C15 mm Hg(lit.)
- Density
- 1.129 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.534(lit.)
- Flash point:
- 213 °F
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform, Ethyl Acetate
- form
- Solid
- color
- Pale Yellow Oil to Low Melting Colorless
- BRN
- 971048
- CAS DataBase Reference
- 622-86-6(CAS DataBase Reference)
- NIST Chemistry Reference
- Benzene, (2-chloroethoxy)-(622-86-6)
- EPA Substance Registry System
- (2-Chloroethoxy)benzene (622-86-6)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 114278
- Product name
- (2-Chloroethoxy)benzene
- Purity
- 98%
- Packaging
- 10ml
- Price
- $69.8
- Updated
- 2025/07/31
- Product number
- C0240
- Product name
- beta-Chlorophenetole
- Purity
- >95.0%(GC)
- Packaging
- 25mL
- Price
- $83
- Updated
- 2025/07/31
- Product number
- C0240
- Product name
- beta-Chlorophenetole
- Purity
- >95.0%(GC)
- Packaging
- 500mL
- Price
- $817
- Updated
- 2025/07/31
- Product number
- P319625
- Product name
- Phenyl2-ChloroethylEther
- Packaging
- 100g
- Price
- $325
- Updated
- 2021/12/16
- Product number
- 286791
- Product name
- Phenyl 2-chloroethyl ether
- Packaging
- 250g
- Price
- $456
- Updated
- 2021/12/16
2-Phenoxyethyl chloride Chemical Properties,Usage,Production
Chemical Properties
Pale Yellow Oil
Uses
Phenyl 2-Chloroethyl Ether (cas# 622-86-6) is a compound useful in organic synthesis.
Uses
(2-Chloroethoxy)benzene is used in the coupling reaction of benzaldehyde, cinnamyltrimethylsilane and anisole in the synthesis of pseudo-symmetrical tamoxifen derivatives.
Synthesis
122-99-6
622-86-6
At room temperature, 2.5 mL of N-methylpyrrolidone (NMP), 1.38 g (10 mmol) of 2-phenoxyethanol and 1.5 mL (11 mmol) of benzenesulfonyl chloride were added to the reaction flask. The mixture was stirred well and then the reaction was continuously stirred at 100 °C for 30 min. Upon completion of the reaction, the reaction mixture was cooled to room temperature and subsequently extracted by adding 30 mL of dichloromethane and 30 mL of water. The organic layer was separated and washed with saturated brine and dried over anhydrous sodium sulfate. Dichloromethane was removed by evaporation under reduced pressure to give the crude product. The crude product was purified by column chromatography to give 1.52 g of 2-chlorophenetole in colorless liquid form in 96.8% yield.
References
[1] Patent: CN106187674, 2016, A. Location in patent: Paragraph 0017; 0018
[2] Patent: US2016/347717, 2016, A1. Location in patent: Paragraph 0232; 0233
[3] Patent: US5527816, 1996, A
[4] Chemical Research in Toxicology, 2000, vol. 13, # 1, p. 53 - 62
[5] Patent: CN106146450, 2016, A. Location in patent: Paragraph 0132; 0133; 0134
2-Phenoxyethyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
2-Phenoxyethyl chloride Suppliers
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- Switzerland
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View Lastest Price from 2-Phenoxyethyl chloride manufacturers
- Product
- 2-Phenoxyethyl chloride 622-86-6
- Price
- US $0.00/Kg/Drum
- Min. Order
- 1KG
- Purity
- 99%min
- Supply Ability
- 10 tons
- Release date
- 2021-07-20
- Product
- 2-Phenoxyethyl chloride 622-86-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- g/kg/Ton
- Release date
- 2019-12-25