ChemicalBook > CAS DataBase List > 3S-3-METHYLMORPHOLINE

3S-3-METHYLMORPHOLINE

Product Name: 3S-3-METHYLMORPHOLINE
CAS No.: 350595-57-2
Chemical Name: 3S-3-METHYLMORPHOLINE
Synonyms: (S)-3-Methylmorpholine;3S-3-METHYLMORPHOLINE;(S)-3-MethylMorpholine HCl;Morpholine, 3-Methyl-, (3S)-;3S-3-Methylmorpholine(WX604204);high quality 3S-3-METHYLMORPHOLINE
CBNumber: CB7781119
Molecular Formula: C5H11NO
Formula Weight: 101.15
MOL File: 350595-57-2.mol

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3S-3-METHYLMORPHOLINE Property

Boiling point:: 137.1±15.0 °C(Predicted)
Density: 0.891±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 9.03±0.40(Predicted)
form: liquid
color: colourless
optical activity: Consistent with structure
InChI: InChI=1S/C5H11NO/c1-5-4-7-3-2-6-5/h5-6H,2-4H2,1H3/t5-/m0/s1
InChIKey: SFWWGMKXCYLZEG-YFKPBYRVSA-N
SMILES: N1CCOC[C@@H]1C

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Safety

Hazard Codes: Xn
Risk Statements: 22
RIDADR: 2735
HazardClass: 8
PackingGroup: Ⅲ
HS Code: 2934999090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H225Highly Flammable liquid and vapour

H319Causes serious eye irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P233Keep container tightly closed.

P240Ground/bond container and receiving equipment.

P241Use explosion-proof electrical/ventilating/lighting/…/equipment.

P242Use only non-sparking tools.

P243Take precautionary measures against static discharge.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: M320525
Product name: (S)-3-MethylMorpholine
Packaging: 2.5g
Price: $1175
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0041131
Product name: 3S-3-METHYL MORPHOLINE
Purity: 95.00%
Packaging: 1G
Price: $596.4
Updated: 2021/12/16

AK Scientific

Product number: J90460
Product name: (S)-3-Methylmorpholine
Packaging: 1g
Price: $25
Updated: 2021/12/16

Apolloscientific

Product number: OR308174
Product name: (3S)-3-Methylmorpholine
Packaging: 1g
Price: $72
Updated: 2021/12/16

AK Scientific

Product number: J90460
Product name: (S)-3-Methylmorpholine
Packaging: 5g
Price: $79
Updated: 2021/12/16

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3S-3-METHYLMORPHOLINE Chemical Properties,Usage,Production

Uses

It is useful in preparation of morpholinopyrimidine derivatives as mTOR kinase inhibitors for the treatment of diseases mediated by mTOR kinase and/or one or more PI3K enzymes.

Uses

(3S)-3-Methylmorpholine is useful in preparation of morpholinopyrimidine derivatives as mTOR kinase inhibitors for the treatment of diseases mediated by mTOR kinase and/or one or more PI3K enzymes

Synthesis

119844-66-5

350595-57-2

Step-4: Synthesis of (S)-3-methylmorpholine (117): lithium aluminum hydride (87 g, 3.0 eq.) was suspended in anhydrous tetrahydrofuran (1500 mL) in a three necked round bottomed flask at 0°C under nitrogen protection. (S)-5-methylmorpholin-3-one (88 g) was dissolved in anhydrous tetrahydrofuran (500 mL) and slowly added dropwise to the reaction system at the same temperature. The reaction mixture was gradually warmed to room temperature and stirred continuously overnight. Upon completion of the reaction, it was quenched sequentially with water (100 mL), 2N sodium hydroxide solution (200 mL), and water (300 mL) (using Fisher post-treatment method) and stirred for 30 minutes. Subsequently, a 2% methanol/dichloromethane mixture (1000 mL) was added and stirring was continued for 1.0 hour. The crude product was filtered through a diatomaceous earth pad, and the filtrate was dried over anhydrous sodium sulfate and finally concentrated on a rotary evaporator at a low water bath temperature of 20-25 °C to afford the target product (S)-3-methylmorpholine (55 g, 71% yield).

References

[1] Patent: WO2014/16849, 2014, A2. Location in patent: Page/Page column 126; 127; 128
[2] Synthesis (Germany), 2014, vol. 46,
[3] Patent: US2008/255114, 2008, A1. Location in patent: Page/Page column 17
[4] Patent: EP1785418, 2007, A1. Location in patent: Page/Page column 148
[5] Patent: CN106749081, 2017, A. Location in patent: Paragraph 0016; 0017; 0018; 0019; 0020; 0021

3S-3-METHYLMORPHOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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3S-3-METHYLMORPHOLINE Suppliers

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View Lastest Price from 3S-3-METHYLMORPHOLINE manufacturers

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: (S)-3-methylmorpholine 350595-57-2
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2021-09-14

Hong Kong Tiansheng New Material Trading Co., Ltd

Product: (3S)-3-methylmorpholine 350595-57-2
Price: US $100.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10KG
Release date: 2021-09-17

Career Henan Chemical Co

Product: 3S-3-METHYLMORPHOLINE 350595-57-2
Price: US $5.00/KG
Min. Order: 1KG
Purity: 95%-98%
Supply Ability: 100kg
Release date: 2019-09-04

350595-57-2, 3S-3-METHYLMORPHOLINERelated Search:

Scopolamine butylbromide Scopolamine hydrobromide Scopine hydrochloride SCOPOLAMINE METHYL NITRATE (5R)-3,4,5,6-Tetrahydro-5-phenyl-4(H)-1,4-oxazin-2-one Methscopolamine bromide 3-methylmorpholine Anisodine hydrobromide PHENDIMETRAZINE BITARTRATE PHENDIMETRAZINE HYOSCINE HYDROCHLORIDE SCOPOLAMINE N-OXIDE HYDROBROMIDE Benzyl (2R,3S)-(-)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate tert-Butyl (2R,3S)-(-)-6-oxo-2,3-diphenyl-4-morpholinecarboxylate Anisodine APOHYOSCINE (-)-SCOPOLAMINE PERCHLORATE SCOPOLAMINE METHYL CHLORIDE, [N-METHYL-3H]

3S-3-METHYLMORPHOLINE

(S)-3-Methylmorpholine

(S)-3-MethylMorpholine HCl

Morpholine, 3-Methyl-, (3S)-

3S-3-Methylmorpholine(WX604204)

high quality 3S-3-METHYLMORPHOLINE

350595-57-2

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