3S-3-METHYLMORPHOLINE
- Product Name
- 3S-3-METHYLMORPHOLINE
- CAS No.
- 350595-57-2
- Chemical Name
- 3S-3-METHYLMORPHOLINE
- Synonyms
- (S)-3-Methylmorpholine;3S-3-METHYLMORPHOLINE;(S)-3-MethylMorpholine HCl;Morpholine, 3-Methyl-, (3S)-;3S-3-Methylmorpholine(WX604204);high quality 3S-3-METHYLMORPHOLINE
- CBNumber
- CB7781119
- Molecular Formula
- C5H11NO
- Formula Weight
- 101.15
- MOL File
- 350595-57-2.mol
3S-3-METHYLMORPHOLINE Property
- Boiling point:
- 137.1±15.0 °C(Predicted)
- Density
- 0.891±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2–8 °C
- pka
- 9.03±0.40(Predicted)
- form
- liquid
- color
- colourless
- optical activity
- Consistent with structure
- InChI
- InChI=1S/C5H11NO/c1-5-4-7-3-2-6-5/h5-6H,2-4H2,1H3/t5-/m0/s1
- InChIKey
- SFWWGMKXCYLZEG-YFKPBYRVSA-N
- SMILES
- N1CCOC[C@@H]1C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233Keep container tightly closed.
P240Ground/bond container and receiving equipment.
P241Use explosion-proof electrical/ventilating/lighting/…/equipment.
P242Use only non-sparking tools.
P243Take precautionary measures against static discharge.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- M320525
- Product name
- (S)-3-MethylMorpholine
- Packaging
- 2.5g
- Price
- $1175
- Updated
- 2021/12/16
- Product number
- CCH0041131
- Product name
- 3S-3-METHYL MORPHOLINE
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $596.4
- Updated
- 2021/12/16
- Product number
- J90460
- Product name
- (S)-3-Methylmorpholine
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
- Product number
- OR308174
- Product name
- (3S)-3-Methylmorpholine
- Packaging
- 1g
- Price
- $72
- Updated
- 2021/12/16
- Product number
- J90460
- Product name
- (S)-3-Methylmorpholine
- Packaging
- 5g
- Price
- $79
- Updated
- 2021/12/16
3S-3-METHYLMORPHOLINE Chemical Properties,Usage,Production
Uses
It is useful in preparation of morpholinopyrimidine derivatives as mTOR kinase inhibitors for the treatment of diseases mediated by mTOR kinase and/or one or more PI3K enzymes.
Uses
(3S)-3-Methylmorpholine is useful in preparation of morpholinopyrimidine derivatives as mTOR kinase inhibitors for the treatment of diseases mediated by mTOR kinase and/or one or more PI3K enzymes
Synthesis
119844-66-5
350595-57-2
Step-4: Synthesis of (S)-3-methylmorpholine (117): lithium aluminum hydride (87 g, 3.0 eq.) was suspended in anhydrous tetrahydrofuran (1500 mL) in a three necked round bottomed flask at 0°C under nitrogen protection. (S)-5-methylmorpholin-3-one (88 g) was dissolved in anhydrous tetrahydrofuran (500 mL) and slowly added dropwise to the reaction system at the same temperature. The reaction mixture was gradually warmed to room temperature and stirred continuously overnight. Upon completion of the reaction, it was quenched sequentially with water (100 mL), 2N sodium hydroxide solution (200 mL), and water (300 mL) (using Fisher post-treatment method) and stirred for 30 minutes. Subsequently, a 2% methanol/dichloromethane mixture (1000 mL) was added and stirring was continued for 1.0 hour. The crude product was filtered through a diatomaceous earth pad, and the filtrate was dried over anhydrous sodium sulfate and finally concentrated on a rotary evaporator at a low water bath temperature of 20-25 °C to afford the target product (S)-3-methylmorpholine (55 g, 71% yield).
References
[1] Patent: WO2014/16849, 2014, A2. Location in patent: Page/Page column 126; 127; 128
[2] Synthesis (Germany), 2014, vol. 46,
[3] Patent: US2008/255114, 2008, A1. Location in patent: Page/Page column 17
[4] Patent: EP1785418, 2007, A1. Location in patent: Page/Page column 148
[5] Patent: CN106749081, 2017, A. Location in patent: Paragraph 0016; 0017; 0018; 0019; 0020; 0021
3S-3-METHYLMORPHOLINE Preparation Products And Raw materials
Raw materials
Preparation Products
3S-3-METHYLMORPHOLINE Suppliers
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- Germany
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View Lastest Price from 3S-3-METHYLMORPHOLINE manufacturers
- Product
- (S)-3-methylmorpholine 350595-57-2
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2021-09-14
- Product
- (3S)-3-methylmorpholine 350595-57-2
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10KG
- Release date
- 2021-09-17
- Product
- 3S-3-METHYLMORPHOLINE 350595-57-2
- Price
- US $5.00/KG
- Min. Order
- 1KG
- Purity
- 95%-98%
- Supply Ability
- 100kg
- Release date
- 2019-09-04