D-Alanine

Product Name: D-Alanine
CAS No.: 338-69-2
Chemical Name: D-Alanine
Synonyms: D-ALA;H-D-ALA-OH;(R)-2-aMinopropanoic acid;D-alaine;(R)-Alanine;D-ALPHA-ALANINE;D-AL;Canef;Cranoc;Vastin
CBNumber: CB7783360
Molecular Formula: C3H7NO2
Formula Weight: 89.09
MOL File: 338-69-2.mol

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D-Alanine Property

Melting point:: 291 °C (dec.)(lit.)
alpha: -14.5 º (c=10, 6N HCl)
Boiling point:: 212.9±23.0 °C(Predicted)
Density: 1.4310 (estimate)
refractive index: -14 ° (C=2, 6mol/L HCl)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: H2O: soluble
form: Crystalline Powder or Crystals
pka: 2.31±0.10(Predicted)
color: White to off-white
Odor: odorless
optical activity: Consistent with structure
Water Solubility: 155 g/L (20 ºC)
Merck: 14,204
BRN: 1720249
LogP: -0.574 (est)
CAS DataBase Reference: 338-69-2(CAS DataBase Reference)
NIST Chemistry Reference: D-Alanine(338-69-2)
EPA Substance Registry System: D-Alanine (338-69-2)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 24/25-36-26
WGK Germany: 3
TSCA: Yes
HazardClass: IRRITANT
HS Code: 29224995

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: A7377
Product name: D-Alanine
Purity: ≥98% (HPLC)
Packaging: 5g
Price: $59.1
Updated: 2025/07/31

Sigma-Aldrich

Product number: A7377
Product name: D-Alanine
Purity: ≥98% (HPLC)
Packaging: 25g
Price: $203
Updated: 2025/07/31

TCI Chemical

Product number: A0177
Product name: D-Alanine
Purity: >98.0%(T)
Packaging: 5g
Price: $29
Updated: 2025/07/31

TCI Chemical

Product number: A0177
Product name: D-Alanine
Purity: >98.0%(T)
Packaging: 25g
Price: $82
Updated: 2025/07/31

Sigma-Aldrich

Product number: A7377
Product name: D-Alanine
Purity: ≥98% (HPLC)
Packaging: 100g
Price: $678
Updated: 2025/07/31

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D-Alanine Chemical Properties,Usage,Production

Chemical Properties

A white crystalline Powder with no peculiar smell and a sweet taste. It is easily soluble in water, slightly soluble in ethanol, and insoluble in acetone and ether. The decomposition point is 297°C. The specific rotation is [α]25D -1.8° (0.5–2.0 mg/ml, H2O) and [α]25D -14.6° (0.5–2.0 mg/ml, 5 mol/L HCl).

Uses

D-Alanine is essential for the biosynthesis of peptidoglycan crosslinking sub-units that are used for bacterial cell walls.

Application

D-Alanine is a LHRH-antagonists, e.g., Abarelix (antineoplas- tic)

Definition

ChEBI: D-alanine is the D-enantiomer of alanine. It has a role as a human metabolite, an EC 4.3.1.15 (diaminopropionate ammonia-lyase) inhibitor and an Escherichia coli metabolite. It is a D-alpha-amino acid and an alanine. It is a conjugate base of a D-alaninium. It is a conjugate acid of a D-alaninate. It is an enantiomer of a L-alanine. It is a tautomer of a D-alanine zwitterion.

Preparation

D-Alanine can be obtained by hydrolysis and refining of proteins such as gelatin, sericin and corn protein, or it can be synthesized by chemical methods.

General Description

Alanine is a non essential amino acid.

Biochem/physiol Actions

D-Alanine is the non-proteinogenic form of alanine which is used in bacterial cell wall biosynthesis. D-Alanine is used to study the specificity and kinetics of alanine racemase(s) (alaR).

Purification Methods

Crystallise alanine from H2O or aqueous EtOH, i.e. crystallise it from 25% EtOH in water, or recrystallise it from 62.5% EtOH, wash it with EtOH and dry it to constant weight in vacuo over P2O5. [Gutter & Kegeles J Am Chem Soc 75 3893 1953, Walsh J Biol Chem 264 2394 1989.] 2,2'-Iminodipropionic acid is a likely impurity. [Beilstein 4 IV 2480. 2481.]

References

[1] ISAO UMEMURA. d-Alanine production from dl-alanine by Candida maltosa with asymmetric degrading activity[J]. Applied Microbiology and Biotechnology, 1992, 36 6: 722-726. DOI:10.1007/BF00172182.
[2] TIAN (AUTUMN) QIU. Biodistribution and racemization of gut-absorbed l/d-alanine in germ-free mice[J]. Communications Biology, 2023: 1-11. DOI:10.1038/s42003-023-05209-y.
[3] AMIT PRIYADARSHI . Structural insights into the alanine racemase from Enterococcus faecalis[J]. Biochimica et biophysica acta. Proteins and proteomics, 2009, 1794 7: Pages 1030-1040. DOI:10.1016/j.bbapap.2009.03.006.
[4] CINDY J. LEE Jonathan V S Tian A Qiu. d-Alanine: Distribution, origin, physiological relevance, and implications in disease[J]. Biochimica et biophysica acta. Proteins and proteomics, 2020, 1868 11: Article 140482. DOI:10.1016/j.bbapap.2020.140482.

D-Alanine Preparation Products And Raw materials

Raw materials

2-Acetylamino-propionic acid

Preparation Products

BOC-D-Alanine Alitame Enalapril Imidapril D-Alaninamide, L-.alpha.-aspartyl-N-(2,2,4,4-tetramethyl-3-thietanyl)-, hydrate (2:5) Glycine Bilirubin D-Cycloserine DL-Alanine

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View Lastest Price from D-Alanine manufacturers

Anhuyan (Hainan) Biotechnology Co., LTD

Product: D-Alanine 338-69-2
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 20000T
Release date: 2025-06-06

WUHAN FORTUNA CHEMICAL CO., LTD

Product: D-Alanine 338-69-2
Price: US $0.00/Kg/Drum
Min. Order: 1KG
Purity: 98%min AJI
Supply Ability: 1000kg
Release date: 2021-09-22

Hebei Chuanghai Biotechnology Co., Ltd

Product: D-Alanine 338-69-2
Price: US $0.00-0.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-25

338-69-2, D-AlanineRelated Search:

Phenprobamate EC 2.6.1.2 D(+)-Tryptophan D-Aspartic acid D-Valine D-Alanine Methyl Ester Hydrochloride D-Alanyl-D-alanine Citric acid Ascoric Acid 1-Amino-1-cyclohexanecarboxylic acid D(-)-allo-Threonine D-tert-Butylglycine 4-Hydroxy-D-(-)-2-phenylglycine N-Methyl-D-aspartic acid D-Serine L-Alanine D-Cystine Cycloleucine

D-ALANINE, >=98% (HPLC)

291°C (dec)

D-Alanine≥ 98% (Titration: Dried basis)

D-2-AMINOPROPIONIC ACID

D-2-AMINOPROPANOIC ACID

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(2R)-2-Aminopropionic acid

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Cranoc

Vastin

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338-69-2

38-69-2