Gontivimab

Product Name: Gontivimab
CAS No.: 1257358-38-5
Chemical Name: Gontivimab
Synonyms: Gontivimab;Research Grade Gontivimab;Research Grade Gontivimab (DVV02806)
CBNumber: CB78080962
Formula Weight: 0
MOL File: Mol file

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Hazard and Precautionary Statements (GHS)

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Gontivimab Chemical Properties,Usage,Production

Uses

Gontivimab (ALX-0171; VR-465) is a poent anti-RSV prefusion F protein nanobody with a KD value of 0.113 nM. Gontivimab shows antiviral activity. Gontivimab reduces the RSV load in the nose and lung[1].

in vivo

Gontivimab (1-68 mg/kg; intranasal administration or nebulization) reduces the RSV load in the nose and lungs in rats^[1].

Animal Model:	Rats (RSV Tracy)^[1]
Dosage:	1-68 mg/kg
Administration:	Intranasal administration or nebulization; once (day 2 or day 3) or twice (day 2 and day 3)
Result:	Resulted in significant viral load reductions in the lungs ranging.

References

[1] Detalle L, et al. Generation and Characterization of ALX-0171, a Potent Novel Therapeutic Nanobody for the Treatment of Respiratory Syncytial Virus Infection. Antimicrob Agents Chemother. 2015 Oct 5;60(1):6-13. DOI:10.1128/AAC.01802-15

Gontivimab Preparation Products And Raw materials

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Preparation Products

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Gontivimab Suppliers

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Gontivimab

Research Grade Gontivimab (DVV02806)

Research Grade Gontivimab

1257358-38-5