ChemicalBook > CAS DataBase List > Telisotuzumab
Telisotuzumab
- Product Name
- Telisotuzumab
- CAS No.
- 1781223-80-0
- Chemical Name
- Telisotuzumab
- Synonyms
- Telisotuzumab;ABT-700|||Mab-224G11;Telisotuzumab (anti-HGFR);Research Grade Telisotuzumab;Research Grade Telisotuzumab(DHC34203)
- CBNumber
- CB78081000
- Formula Weight
- 0
- MOL File
- Mol file
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Telisotuzumab Property
- form
- Liquid
- color
- Colorless to light yellow
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Telisotuzumab Chemical Properties,Usage,Production
Uses
Telisotuzumab (ABT-700) is a human recombinant bivalent antibody, a therapeutic antibody against the hepatocyte growth factor receptor (MET) that binds c-Met with high affinity and inhibits c-Met signaling. Telisotuzumab has antitumor activity[1].
in vivo
Telisotuzumab (ABT-700) (i.p., 2.5-40 mg/kg, twice a week, 90 days) effectively antagonizes constitutively activated c-Met and downstream signaling, thereby inhibiting tumor growth in SCID mice with Hs746T cells[1].
| Animal Model: | SCID mice with Hs746T cells[1] |
| Dosage: | 2.5-40 mg/kg |
| Administration: | i.p., twice a week, 90 days |
| Result: | Reduced total and phosphorylated c-Met as well as phosphorylated Akt and Erk. Complete tumor regression at doses above 10 mg/kg but no effective inhibition of tumor growth at doses below 5mg/kg. |
References
[1] Jieyi Wang, et al. Anti-c-Met monoclonal antibody ABT-700 breaks oncogene addiction in tumors with MET amplification. BMC Cancer. 2016 Feb 16;16:105. DOI:10.1186/s12885-016-2138-z
Telisotuzumab Preparation Products And Raw materials
Raw materials
Preparation Products
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