ChemicalBook > CAS DataBase List > A 205804

A 205804

Product Name
A 205804
CAS No.
251992-66-2
Chemical Name
A 205804
Synonyms
CS-635;A 205804;A-205804;A 205804;A 205804 USP/EP/BP;A205804;A 205804;A-205804;IKK-16 (IKK Inhibitor VII);4-(p-tolylthio)thieno[2,3-c]pyridine-2-carboxamide;4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide;Thieno[2,3-c]pyridine-2-carboxamide, 4-[(4-methylphenyl)thio]-;4-[(4-methylphenyl)sulfanyl]thieno[2,3-c]pyridine-2-carboxam...
CBNumber
CB7838925
Molecular Formula
C15H12N2OS2
Formula Weight
300.4
MOL File
251992-66-2.mol
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A 205804 Property

Melting point:
198-199℃
Boiling point:
581.3±45.0 °C(Predicted)
Density 
1.40±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,2-8°C
solubility 
≥30 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH
pka
15.12±0.30(Predicted)
form 
powder to crystal
color 
White to Orange to Green
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Safety

HS Code 
2934.99.9001
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TCI Chemical
Product number
T3498
Product name
4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carboxamide
Purity
>95.0%(HPLC)
Packaging
25mg
Price
$178
Updated
2024/03/01
TCI Chemical
Product number
T3498
Product name
4-(p-Tolylthio)thieno[2,3-c]pyridine-2-carboxamide
Purity
>95.0%(HPLC)
Packaging
100mg
Price
$488
Updated
2024/03/01
Cayman Chemical
Product number
21252
Product name
A-205804
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21252
Product name
A-205804
Purity
≥95%
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
21252
Product name
A-205804
Purity
≥95%
Packaging
10mg
Price
$130
Updated
2024/03/01
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A 205804 Chemical Properties,Usage,Production

Description

A-205804 is a potent inhibitor of E-selectin and ICAM-1 expression in human vascular endothelial cells stimulated with TNF-α (IC50s = 20 and 25 nM, respectively). It does not block expression of VCAM-1 (IC50 > 1,000 nM).

Uses

4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide is a reagent used in the preparation of selective inhibitors of cell adhesion molecule expression in human endothelial cells.

Definition

ChEBI: 4-[(4-methylphenyl)thio]-2-thieno[2,3-c]pyridinecarboxamide is an aryl sulfide.

Biological Activity

Selective inhibitor of E-selectin and ICAM-1 expression (IC 50 values are 20, 25 and > 1000 nM for TNF- α -induced E-selectin, ICAM-1 and VCAM-1 expression respectively). Effective inhibitor of cell-cell adhesion in an in vitro flow experiment.

storage

Store at +4°C

References

[1]. stewart, a.o., et al., discovery of inhibitors of cell adhesion molecule expression in human endothelial cells. 1. selective inhibition of icam-1 and e-selectin expression. j med chem, 2001. 44(6): p. 988-1002.
[2]. chang, c.z., et al., valproic acid attenuates intercellular adhesion molecule-1 and e-selectin through a chemokine ligand 5 dependent mechanism and subarachnoid hemorrhage induced vasospasm in a rat model. j inflamm (lond), 2015. 12: p. 27.
[3]. zhu, g.d., et al., selective inhibition of icam-1 and e-selectin expression in human endothelial cells. 2. aryl modifications of 4-(aryloxy)thieno[2,3-c]pyridines with fine-tuning at c-2 carbamides. j med chem, 2001. 44(21): p. 3469-87.
[4]. zhu, g.d., et al., synthesis and mode of action of (125)i- and (3)h-labeled thieno[2,3-c]pyridine antagonists of cell adhesion molecule expression. j org chem, 2002. 67(3): p. 943-8.

A 205804 Preparation Products And Raw materials

Raw materials

Preparation Products

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A 205804 Suppliers

China 66 Germany 1 India 2 Japan 2 United Kingdom 1 United States 14 Global 86
BOC Sciences
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InvivoChem
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Cckinase, Inc.
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251992-66-2, A 205804Related Search:

p-Tolualdehyde 2-Methylpropanedioic acid p-Toluenethiol Poly(methyl methacrylate) (S)-(+)-Benzyl glycidyl ether Benzyl alcohol 4'-Hydroxyacetophenone Selumetinib Ki16198 Nintedanib Raltitrexed TAK875 PLX4032 Thieno[2,3-c]pyridine, 2-methyl- (9CI) A 205804

  • A 205804
  • 4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide
  • CS-635
  • A205804;A 205804;A-205804
  • A 205804,4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxaMide
  • 4-(p-tolylthio)thieno[2,3-c]pyridine-2-carboxamide
  • Thieno[2,3-c]pyridine-2-carboxamide, 4-[(4-methylphenyl)thio]-
  • 4-[(4-Methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide A-205804
  • IKK-16 (IKK Inhibitor VII)
  • A-205804;A 205804
  • A 205804 USP/EP/BP
  • 4-[(4-methylphenyl)sulfanyl]thieno[2,3-c]pyridine-2-carboxam...
  • Inhibitor,molecules,Adhesion,ICAM-1,A205804,E-selectin,A-205804,Integrin,A 205804,inhibit
  • 251992-66-2
  • Inhibitors