ChemicalBook > CAS DataBase List > 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE

5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE

Product Name
5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE
CAS No.
874902-19-9
Chemical Name
5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE
Synonyms
CS-752;LY 2183240;LY2183240 powder;LY-2183240 MN-25;LY2183240/LY-2183240;N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide;5-(biphenyl-4-ylMethyl)-N,N-diMethyl-1H-tetrazole-1-carboxaMide;5-Biphenyl-4-ylmethyl-tetrazole-1-carboxylic acid dimethylamide;1H-Tetrazole-1-carboxamide, 5-([1,1′-biphenyl]-4-ylmethyl)-N,N-dimethyl-;5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE
CBNumber
CB7842012
Molecular Formula
C17H17N5O
Formula Weight
307.35
MOL File
874902-19-9.mol
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5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE Property

Melting point:
87-88℃
Boiling point:
506.1±53.0 °C(Predicted)
Density 
1.21
storage temp. 
Sealed in dry,2-8°C
solubility 
Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (up to 15 mg/ml).
pka
0.01±0.10(Predicted)
form 
White to off-white solid.
color 
White
Stability:
Stable for 1 year as supplied. Solutions in DMSO of ethanol may be stored at -20°C for up to 1 month
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Safety

Hazard Codes 
Xn
Risk Statements 
22
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10008663
Product name
LY2183240
Purity
≥98%
Packaging
1mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
10008663
Product name
LY2183240
Purity
≥98%
Packaging
5mg
Price
$252
Updated
2024/03/01
Tocris
Product number
2452
Product name
LY2183240
Purity
≥98%(HPLC)
Packaging
1
Price
$112
Updated
2021/12/16
Tocris
Product number
2452
Product name
LY2183240
Purity
≥98%(HPLC)
Packaging
10
Price
$237
Updated
2021/12/16
TRC
Product number
L503140
Product name
LY2183240
Packaging
250mg
Price
$790
Updated
2021/12/16
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5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE Chemical Properties,Usage,Production

Description

LY-2183240 (874902-19-9) is highly potent inhibitor of cellular anandamide uptake (IC50 = 0.27nM1, 15nM2). LY-2183240 has also been found2-4 to be an inhibitor of fatty acid amide hydrolase (FAAH) – IC50 = 14nM4, diacylglycerol lipase (DAGL) and monoacylglycerol lipase (MAGL) – IC50 = 5.3 nM3.

Uses

LY2183240 is a potent inhibitor of FAAH activity, and the uptake and enzymatic hydrolysis of anandamide. Synthetic Cannabinoids

Definition

ChEBI: N,N-dimethyl-5-[(4-phenylphenyl)methyl]-1-tetrazolecarboxamide is a member of biphenyls.

Biological Activity

Novel and highly potent blocker of anandamide uptake (IC 50 = 270 pM). Inhibits fatty acid amide hydrolase (FAAH) activity (IC 50 = 12.4 nM). Following i.p. administration in rats, increases brain anandamide concentration and exerts antinociceptive effects in formalin model of pain.

References

1) Moore et al., (2005), Identification of a high-affinity binding site involved in the transport of endocannabinoids; Proc. Natl. Acad. Sci. USA, 102 17852 2) Ortar et al. (2008), Carbamoyl tetrazoles as inhibitors of endocannabinoid inactivation: A critical revision; Eur. .J. Med. Chem., 43 62 3) Alexander and Cravatt (2006), The putative endocannabinoid transport blocker LY2183240 is a potent inhibitor of FAAH and several other brain serine hydrolases; J. Am. Chem. Soc., 128 9699 4) Dickason-Chesterfield et al. (2006), Pharmacological Characterization of Endocannabinoid Transport and Fatty Acid Amide Hydrolase Inhibitors; Cell. Mol. Neurobiol., 26 405

5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE Suppliers

China 64 Germany 1 United Kingdom 1 United States 13 Global 79
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77
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View Lastest Price from 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE manufacturers

Qiuxian Baitai New Material Co., LTD
Product
LY2183240 powder 874902-19-9
Price
US $29.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500ton/Month
Release date
2021-07-30
Career Henan Chemical Co
Product
N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide 874902-19-9
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
200kg
Release date
2020-01-09

874902-19-9, 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDERelated Search:

Simvastatin EPA LY 171883 Zileuton 3,3',5,5'-Tetramethylbenzidine dihydrochloride Biphenyl Bifenthrin BIFENAZATE FIREMASTER BP-6 Thiamethoxam 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE 1H-TETRAZOLE, 5-(P-METHYLBENZYL)-

  • 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE
  • LY 2183240
  • LY-2183240 MN-25
  • 1H-Tetrazole-1-carboxamide, 5-([1,1′-biphenyl]-4-ylmethyl)-N,N-dimethyl-
  • 5-Biphenyl-4-ylmethyl-tetrazole-1-carboxylic acid dimethylamide
  • N,N-dimethyl-5-[(4-phenylphenyl)methyl]tetrazole-1-carboxamide
  • 5-(biphenyl-4-ylMethyl)-N,N-diMethyl-1H-tetrazole-1-carboxaMide
  • LY2183240/LY-2183240
  • CS-752
  • LY2183240 powder
  • Inhibitor,brain,uptake,transport,hydrolases,Fatty acid amide hydrolase,LY2183240,Autophagy,LY 2183240,serine,anandamide,FAAH,inhibit,LY-2183240
  • 5-[[(1,1'-BIPHENYL)-4-YL]METHYL]-N,N-DIMETHYL-1H-TETRAZOLE-1-CARBOXAMIDE
  • 874902-19-9