ChemicalBook > CAS DataBase List > Phenylacetyl chloride

Phenylacetyl chloride

Product Name
Phenylacetyl chloride
CAS No.
103-80-0
Chemical Name
Phenylacetyl chloride
Synonyms
phenylacetyl;Benzeneacetyl chloride;-Toluylchloride;A-TOLUYL CHLORIDE;AKOS BBS-00003909;ylacetyl chloride;PHENACETYL CHLORIDE;Phenyl acetyl chlori;henylacetyl chloride;Ethephon Impurity 14
CBNumber
CB7852631
Molecular Formula
C8H7ClO
Formula Weight
154.59
MOL File
103-80-0.mol
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Phenylacetyl chloride Property

Melting point:
264-266 °C(Solv: N,N-dimethylformamide (68-12-2))
Boiling point:
94-95 °C/12 mmHg (lit.)
Density 
1.169 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.5325(lit.)
Flash point:
217 °F
storage temp. 
2-8°C
solubility 
Miscible with alcohol and ether.
form 
clear liquid
color 
Colorless to Light yellow
Sensitive 
Moisture Sensitive
BRN 
742254
Stability:
Stable. Reacts with water. Incompatible with amines, most common metals, moisture, strong oxidizing agents.
LogP
1.628 (est)
CAS DataBase Reference
103-80-0(CAS DataBase Reference)
NIST Chemistry Reference
Benzeneacetyl chloride(103-80-0)
EPA Substance Registry System
Benzeneacetyl chloride (103-80-0)
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Safety

Hazard Codes 
C
Risk Statements 
34-37-14
Safety Statements 
26-36/37/39-45-25-27
RIDADR 
UN 2577 8/PG 2
WGK Germany 
3
F 
21
TSCA 
Yes
HazardClass 
8
PackingGroup 
II
HS Code 
29163900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H290May be corrosive to metals

H314Causes severe skin burns and eye damage

H335May cause respiratory irritation

Precautionary statements

P234Keep only in original container.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P16753
Product name
Phenylacetyl chloride
Purity
98%
Packaging
5g
Price
$107
Updated
2024/03/01
Sigma-Aldrich
Product number
P16753
Product name
Phenylacetyl chloride
Purity
98%
Packaging
100g
Price
$126
Updated
2024/03/01
TCI Chemical
Product number
P0129
Product name
Phenylacetyl Chloride
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$36
Updated
2024/03/01
TCI Chemical
Product number
P0129
Product name
Phenylacetyl Chloride
Purity
>98.0%(GC)(T)
Packaging
100g
Price
$94
Updated
2024/03/01
Alfa Aesar
Product number
B24987
Product name
Phenylacetyl chloride, 98%
Packaging
100g
Price
$42.65
Updated
2024/03/01
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Phenylacetyl chloride Chemical Properties,Usage,Production

Chemical Properties

colourless liquid

Uses

Phenylacetyl chloride is used in the preparation of 1,2-diphenyl-ethanone by reaction with iodobenzene using tetrabutylammonium tetrafluoroborate as a phase transfer catalyst. It is widely used in the chemical industry for manufacturing dyes and pharmaceutical products. It plays an important role in the preparation of penicillin. Further, it is used to prepare esters for flavorings.

Uses

Phenylacetyl chloride is used as a key precursor in the total synthesis of vialinin B. It is employed as a linker to prepare dendrimers and also used in the synthesis of various conjugated aromatic small molecules.

Synthesis Reference(s)

Journal of the American Chemical Society, 96, p. 6469, 1974 DOI: 10.1021/ja00827a034
Organic Syntheses, Coll. Vol. 2, p. 156, 1943

General Description

A colorless volatile liquid with a strong odor. Denser than water. Contact may severely irritate skin, eyes and mucous membranes. May be toxic by ingestion. May also be combustible.

Air & Water Reactions

Soluble in water. Fumes in air. Decomposes in water or steam to form very corrosive hydrogen chloride gas.

Reactivity Profile

Phenylacetyl chloride is incompatible with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].

Health Hazard

TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.

Fire Hazard

Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.

Phenylacetyl chloride Preparation Products And Raw materials

Raw materials

Sulfur dioxide Chlorine Thionyl chloride Phenylacetic acid

Preparation Products

1-Chloro-3-Phenylacetone GERANYL PHENYLACETATE Brodifacoum 6-BENZYL-2-THIOURACIL Diethyl(phenylacetyl)malonate Benalaxyl Lorcainide 2-Phenylacetophenone
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Phenylacetyl chloride Suppliers

Americas 1 Austria 1 Belgium 2 China 223 Europe 3 France 3 Germany 9 India 35 Italy 1 Japan 10 Poland 1 Slovakia 1 South Korea 1 Switzerland 3 The Netherlands 1 United Kingdom 9 United States 44 Global 348
Cato Research Chemicals Inc.
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View Lastest Price from Phenylacetyl chloride manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Phenylacetyl chloride 103-80-0
Price
US $100.00/KG
Min. Order
1KG
Purity
99%min
Supply Ability
200TON
Release date
2024-10-28
Hebei Chuanghai Biotechnology Co,.LTD
Product
Phenylacetyl chloride 103-80-0
Price
US $10.00/KG
Min. Order
1KG
Purity
99.%
Supply Ability
10 ton
Release date
2024-08-20
Hebei Mojin Biotechnology Co., Ltd
Product
Phenylacetyl chloride 103-80-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-07-04

103-80-0, Phenylacetyl chlorideRelated Search:

Calcium chloride Benzyloxyacetyl chloride Sodium chloride Choline chloride Polyvinyl chloride Chloroacetyl chloride Trichloroacetyl chloride Ammonium chloride Acetyl chloride Acetoxyacetyl chloride Thionyl chloride Potassium chloride Bromoacetyl chloride Phenoxyacetyl chloride 2-Phenylacetamide Phenylhydrazine hydrochloride Phenylmalonic acid Phenylhydrazine

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