ChemicalBook > CAS DataBase List > 5,6-Difluoroindanone

5,6-Difluoroindanone

Uses

Product Name: 5,6-Difluoroindanone
CAS No.: 161712-77-2
Chemical Name: 5,6-Difluoroindanone
Synonyms: 6-difluoro-2;6-Difluoroindanone;3-dihydroinden-1-one;5,6-Difluoroindanone;5,6-Difluoro-1-indanone;6-chloro-8-methoxythiochroman-4-one;5,6-difluoro-2,3-dihydroinden-1-one;1H-Inden-1-one, 5,6-difluoro-2,3-dihydro-
CBNumber: CB7948200
Molecular Formula: C9H6F2O
Formula Weight: 168.14
MOL File: 161712-77-2.mol

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5,6-Difluoroindanone Property

Boiling point:: 251.3±40.0 °C(Predicted)
Density: 1.362±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: solid
color: White to light yellow
InChI: InChI=1S/C9H6F2O/c10-7-3-5-1-2-9(12)6(5)4-8(7)11/h3-4H,1-2H2
InChIKey: OSJRTWXVMCRBKZ-UHFFFAOYSA-N
SMILES: C1(=O)C2=C(C=C(F)C(F)=C2)CC1

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
TSCA: No
HS Code: 2914790090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D446198
Product name: 5,6-Difluoro-1-indanone
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: D446198
Product name: 5,6-Difluoro-1-indanone
Packaging: 100mg
Price: $60
Updated: 2021/12/16

ChemSupplyAustralia

Product number: 300349
Product name: 5,6-Difluoro-2,3-dihydro-1H-inden-1-one, 96%
Packaging: 250mg
Price: $93.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD104792
Product name: 5,6-difluoro-2,3-dihydroinden-1-one
Packaging: 250mg
Price: $100
Updated: 2021/12/16

Matrix Scientific

Product number: 090790
Product name: 5,6-Difluoro-1-indanone
Purity: 95+%
Packaging: 250mg
Price: $364
Updated: 2021/12/16

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5,6-Difluoroindanone Chemical Properties,Usage,Production

Uses

5,6-Difluoro-1-indanone is a ketone organic compound that can be used as an organic reagent.

Synthesis

161712-76-1

161712-77-2

Step 2: To a carbon disulfide solution (300 mL) containing AlCl3 (76.4 g, 572.6 mmol) was added 3-(3,4-difluorophenyl)propionyl chloride (33.4 g, 163.6 mmol) to a carbon disulfide solution (120 mL) dropwise over 10 minutes at 0°C. The reaction mixture was stirred at 0°C for 30 minutes and then heated to reflux for 4 hours. After the reaction was completed, it was cooled to room temperature and the reaction solution was carefully poured onto crushed ice. The carbon disulfide layer was separated and the aqueous layer was extracted with ethyl acetate. The organic layers were combined, dried with MgSO4 and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (eluent: 5-10% ethyl acetate/hexane) to afford 5,6-difluoro-2,3-dihydro-1H-inden-1-one 19.3 g (114.9 mmol, 70% yield) as a white solid.1H NMR (400 MHz, CDCl3) δ ppm: 7.50 (t, 1H, J=8.0 Hz),. 7.24 (t, 1H, J=6.6Hz), 3.09 (t, 2H, J=5.5Hz), 2.72-2.69 (m, 2H).

References

[1] Patent: US2009/54431, 2009, A1. Location in patent: Page/Page column 40
[2] Patent: US2006/223830, 2006, A1. Location in patent: Page/Page column 40
[3] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 5, p. 602 - 606
[4] Patent: WO2015/88564, 2015, A1. Location in patent: Paragraph 00254
[5] Patent: CN102516115, 2016, B. Location in patent: Paragraph 0283; 0284

5,6-Difluoroindanone Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5,6-Difluoroindanone manufacturers

Career Henan Chemical Co

Product: 5,6-Difluoroindanone 161712-77-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1kg-1000kg
Release date: 2020-01-02

161712-77-2, 5,6-DifluoroindanoneRelated Search:

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1H-Inden-1-one, 5,6-difluoro-2,3-dihydro-

5,6-Difluoro-1-indanone

5,6-Difluoroindanone

5,6-difluoro-2,3-dihydroinden-1-one

3-dihydroinden-1-one

6-difluoro-2

6-Difluoroindanone

6-chloro-8-methoxythiochroman-4-one

161712-77-2

Indanone & Indene