5,6-Difluoroindanone
Uses- Product Name
- 5,6-Difluoroindanone
- CAS No.
- 161712-77-2
- Chemical Name
- 5,6-Difluoroindanone
- Synonyms
- 6-difluoro-2;6-Difluoroindanone;3-dihydroinden-1-one;5,6-Difluoroindanone;5,6-Difluoro-1-indanone;6-chloro-8-methoxythiochroman-4-one;5,6-difluoro-2,3-dihydroinden-1-one;1H-Inden-1-one, 5,6-difluoro-2,3-dihydro-
- CBNumber
- CB7948200
- Molecular Formula
- C9H6F2O
- Formula Weight
- 168.14
- MOL File
- 161712-77-2.mol
5,6-Difluoroindanone Property
- Boiling point:
- 251.3±40.0 °C(Predicted)
- Density
- 1.362±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- color
- White to light yellow
- InChI
- InChI=1S/C9H6F2O/c10-7-3-5-1-2-9(12)6(5)4-8(7)11/h3-4H,1-2H2
- InChIKey
- OSJRTWXVMCRBKZ-UHFFFAOYSA-N
- SMILES
- C1(=O)C2=C(C=C(F)C(F)=C2)CC1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- D446198
- Product name
- 5,6-Difluoro-1-indanone
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- D446198
- Product name
- 5,6-Difluoro-1-indanone
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- 300349
- Product name
- 5,6-Difluoro-2,3-dihydro-1H-inden-1-one, 96%
- Packaging
- 250mg
- Price
- $93.5
- Updated
- 2021/12/16
- Product number
- FD104792
- Product name
- 5,6-difluoro-2,3-dihydroinden-1-one
- Packaging
- 250mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- 090790
- Product name
- 5,6-Difluoro-1-indanone
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $364
- Updated
- 2021/12/16
5,6-Difluoroindanone Chemical Properties,Usage,Production
Uses
5,6-Difluoro-1-indanone is a ketone organic compound that can be used as an organic reagent.
Synthesis
161712-76-1
161712-77-2
Step 2: To a carbon disulfide solution (300 mL) containing AlCl3 (76.4 g, 572.6 mmol) was added 3-(3,4-difluorophenyl)propionyl chloride (33.4 g, 163.6 mmol) to a carbon disulfide solution (120 mL) dropwise over 10 minutes at 0°C. The reaction mixture was stirred at 0°C for 30 minutes and then heated to reflux for 4 hours. After the reaction was completed, it was cooled to room temperature and the reaction solution was carefully poured onto crushed ice. The carbon disulfide layer was separated and the aqueous layer was extracted with ethyl acetate. The organic layers were combined, dried with MgSO4 and concentrated under reduced pressure to remove the solvent. The residue was purified by silica gel column chromatography (eluent: 5-10% ethyl acetate/hexane) to afford 5,6-difluoro-2,3-dihydro-1H-inden-1-one 19.3 g (114.9 mmol, 70% yield) as a white solid.1H NMR (400 MHz, CDCl3) δ ppm: 7.50 (t, 1H, J=8.0 Hz),. 7.24 (t, 1H, J=6.6Hz), 3.09 (t, 2H, J=5.5Hz), 2.72-2.69 (m, 2H).
References
[1] Patent: US2009/54431, 2009, A1. Location in patent: Page/Page column 40
[2] Patent: US2006/223830, 2006, A1. Location in patent: Page/Page column 40
[3] ACS Medicinal Chemistry Letters, 2015, vol. 6, # 5, p. 602 - 606
[4] Patent: WO2015/88564, 2015, A1. Location in patent: Paragraph 00254
[5] Patent: CN102516115, 2016, B. Location in patent: Paragraph 0283; 0284
5,6-Difluoroindanone Preparation Products And Raw materials
Raw materials
Preparation Products
5,6-Difluoroindanone Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from 5,6-Difluoroindanone manufacturers
- Product
- 5,6-Difluoroindanone 161712-77-2
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1kg-1000kg
- Release date
- 2020-01-02