ChemicalBook > CAS DataBase List > BENZAMIL HYDROCHLORIDE

BENZAMIL HYDROCHLORIDE

Product Name: BENZAMIL HYDROCHLORIDE
CAS No.: 161804-20-2
Chemical Name: BENZAMIL HYDROCHLORIDE
Synonyms: Benzamil hydrochloride hydrate;Benzamil hydrate hydrochloride;Benzamil hydrochloride hydrate[B2417];Benzamil hydrochloride, Sodium channel blocker;N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride;5-diamino-6-chloro-N-[imino[(phenylmethyl)amino]methyl]-2-pyrazinecarboxamide;N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate;N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrate hydrochloride;3,5-diamino-N-(N'-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide,hydrochloride;3;5-DIAMINO-6-CHLORO-N-[IMINO[(PHENYLMETHYL)AMINO]METHYL]-2-PYRAZINECARBOXAMIDE; MONOHYDROCHLORIDE
CBNumber: CB7973022
Molecular Formula: C13H15Cl2N7O
Formula Weight: 356.21
MOL File: 161804-20-2.mol

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BENZAMIL HYDROCHLORIDE Property

storage temp.: 2-8°C
solubility: methanol: soluble10mg/mL
form: solid
color: yellow
Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or may be stored at -20°C for up to 3 months.

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B2417
Product name: Benzamil hydrochloride hydrate
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $101.65
Updated: 2025/07/31

Sigma-Aldrich

Product number: B2417
Product name: Benzamil hydrochloride hydrate
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $382
Updated: 2025/07/31

Cayman Chemical

Product number: 14313
Product name: Benzamil (hydrochloride)
Packaging: 5mg
Price: $43
Updated: 2024/03/01

Cayman Chemical

Product number: 14313
Product name: Benzamil (hydrochloride)
Packaging: 10mg
Price: $85
Updated: 2024/03/01

TRC

Product number: B183630
Product name: BenzamilHydrochloride
Packaging: 10mg
Price: $85
Updated: 2021/12/16

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BENZAMIL HYDROCHLORIDE Chemical Properties,Usage,Production

Description

Benzamil (161804-21-2) is a more potent (Ki = 10 nM vs 182 nM1, IC50 = 9 μM2) version of the epithelial sodium channel blocker Amiloride. It is also an inhibitor of Na+/Ca2+ exchange transport (IC50 = 11 μM)2 and the Na+/H+ antiporter (IC50 = 80 nM)2.

Uses

Benzamil Hydrochloride is a specific blocker of sodium channels. It also inhibits epithelial sodium channel (ENaC). Benzamil Hydrochloride is an analog of Amiloride (A578700).

Biochem/physiol Actions

Selective and potent blocker of Na+/H+ and Na+/Ca2+ channels

storage

Store at +4°C

References

[1] A. W. CUTHBERT G. M F. EFFECTS OF SOME PYRAZINECARBOXAMIDES ON SODIUM TRANSPORT IN FROG SKIN[J]. British Journal of Pharmacology, 1978, 63 1: 139-149. DOI:10.1111/j.1476-5381.1978.tb07783.x
[2] T R KLEYMAN E J C. Amiloride and its analogs as tools in the study of ion transport.[J]. Journal of Membrane Biology, 1988, 105 1: 1-21. DOI:10.1007/bf01871102

BENZAMIL HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BENZAMIL HYDROCHLORIDE manufacturers

Career Henan Chemical Co

Product: BENZAMIL HYDROCHLORIDE 161804-20-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%HPLC
Supply Ability: 200KG
Release date: 2020-02-01

161804-20-2, BENZAMIL HYDROCHLORIDERelated Search:

MITOQ Lovastatin Isradipine Nicardipine hydrochloride

Benzamil hydrate hydrochloride

N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrate hydrochloride

N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride hydrate

Benzamil hydrochloride hydrate

3,5-diamino-N-(N'-benzylcarbamimidoyl)-6-chloropyrazine-2-carboxamide,hydrochloride

3;5-DIAMINO-6-CHLORO-N-[IMINO[(PHENYLMETHYL)AMINO]METHYL]-2-PYRAZINECARBOXAMIDE; MONOHYDROCHLORIDE

5-diamino-6-chloro-N-[imino[(phenylmethyl)amino]methyl]-2-pyrazinecarboxamide

N-(Benzylamidino)-3,5-diamino-6-chloropyrazinecarboxamide hydrochloride

Benzamil hydrochloride, Sodium channel blocker

Benzamil hydrochloride hydrate[B2417]

161804-20-2