ChemicalBook > CAS DataBase List > Ethyl 3-(pyridin-2-ylamino)propanoate

Ethyl 3-(pyridin-2-ylamino)propanoate

Product Name: Ethyl 3-(pyridin-2-ylamino)propanoate
CAS No.: 103041-38-9
Chemical Name: Ethyl 3-(pyridin-2-ylamino)propanoate
Synonyms: Dabigatran Impurity 83;3-(Pyridin-2-ylamino)propanoate;Dabigatran Etexilate Impurity 90;N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER;Ethyl 3-(pyridin-2-ylamino)propan;N-2-pyridin-B-alanine ethyl ester;Ethyl 3-(2-PyridylaMino)propanoate;N-2-pyridinyl-β-Alanine,ethylester;Dabigatran Etexilate Intermdiate 4;Ethyl 3-(2-Pyridylamino)propionate
CBNumber: CB81011425
Molecular Formula: C10H14N2O2
Formula Weight: 194.23
MOL File: 103041-38-9.mol

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Ethyl 3-(pyridin-2-ylamino)propanoate Property

Melting point:: 48-50°C
Boiling point:: 125°C/0.2mmHg(lit.)
Density: 1.131±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: DMSO, Methanol
form: Solid
pka: 6.26±0.10(Predicted)
color: White
InChI: InChI=1S/C10H14N2O2/c1-2-14-10(13)6-8-12-9-5-3-4-7-11-9/h3-5,7H,2,6,8H2,1H3,(H,11,12)
InChIKey: UITNIDFEANEWPC-UHFFFAOYSA-N
SMILES: C(OCC)(=O)CCNC1C=CC=CN=1
LogP: 1.54 at 22℃ and pH6

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Safety

HS Code: 2933.39.9200

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TCI Chemical

Product number: E1214
Product name: Ethyl 3-(2-Pyridylamino)propionate
Purity: >98.0%(T)
Packaging: 5g
Price: $26
Updated: 2025/07/31

TCI Chemical

Product number: E1214
Product name: Ethyl 3-(2-Pyridylamino)propionate
Purity: >98.0%(T)
Packaging: 25g
Price: $75
Updated: 2025/07/31

TRC

Product number: E925620
Product name: Ethyl3-(Pyridin-2-ylamino)propanoate
Packaging: 10g
Price: $110
Updated: 2021/12/16

TRC

Product number: E925620
Product name: Ethyl3-(Pyridin-2-ylamino)propanoate
Packaging: 1g
Price: $45
Updated: 2021/12/16

TRC

Product number: E925620
Product name: Ethyl3-(Pyridin-2-ylamino)propanoate
Packaging: 5g
Price: $70
Updated: 2021/12/16

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Ethyl 3-(pyridin-2-ylamino)propanoate Chemical Properties,Usage,Production

Chemical Properties

White Solid

Uses

Dabigatran etexilate intermediate

Uses

Ethyl 3-(2-Pyridylamino)propanoate is an intermediate used in the synthesis of Dabigatran etexilate, as thrombin inhibitors. Ethyl Ester form of P993315.

Synthesis

A method for preparing Ethyl 3-(pyridin-2-ylamino)propanoate comprises the following steps: using 2-aminopyridine and ethyl acrylate as raw materials, using anhydrous ethanol as a solvent, using trifluoromethanesulfonic acid as a catalyst, and heating in an oil bath to control the temperature at 120 to 160° C. for a catalytic reaction for 16 to 20 hours under nitrogen protection. The obtained reaction solution is washed with petroleum ether at a temperature of 35 to 40° C. and a pressure of 0.09 to 0.1 MPa, then concentrated under reduced pressure, and then washed with petroleum ether/ethyl acetate and recrystallized to obtain white flaky crystals of Ethyl 3-(pyridin-2-ylamino)propanoate.

References

[1] Letters in Organic Chemistry, 2015, vol. 12, # 2, p. 146 - 152
[2] Patent: EP2522662, 2012, A1. Location in patent: Page/Page column 19
[3] Patent: WO2012/152855, 2012, A1. Location in patent: Page/Page column 34; 35
[4] Patent: CN103524559, 2016, B. Location in patent: Paragraph 0096; 0099-0101
[5] Patent: WO2015/128875, 2015, A2. Location in patent: Page/Page column 41

Ethyl 3-(pyridin-2-ylamino)propanoate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Ethyl 3-(pyridin-2-ylamino)propanoate manufacturers

Anhuyan (Hainan) Biotechnology Co., LTD

Product: Ethyl 3-(pyridin-2-ylamino)propanoate 103041-38-9
Price: US $0.00-0.00/KG
Min. Order: 0.001KG
Purity: 99%
Supply Ability: 2000000T
Release date: 2025-06-16

Henan Aochuang Chemical Co.,Ltd.

Product: N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER 103041-38-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-10

Hebei Chuanghai Biotechnology Co,.LTD

Product: Ethyl 3- (pyridin-2-ylamino) Propanoate 103041-38-9
Price: US $5.00-2.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2024-08-21

103041-38-9, Ethyl 3-(pyridin-2-ylamino)propanoateRelated Search:

Glycidyl methacrylate 4-Aminobenzamidine dihydrochloride N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]arbonyl]-N-2-pyridinyl-beta-alanine ethyl ester 4-methylbenzenesulfonate Dabigatran ethyl AcOH Salt 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino]propionic acid ethyl ester ETHYL N-[4-(METHYLAMINO)-3-NITROBENZOYL]-N-PYRIDIN-2-YL-SS-ALANINATE 3-[(3-AMINO-4-METHYLAMINO-BENZOYL)-PYRIDIN-2-YL-AMINO]-PROPIONIC ACID ETHYL ESTER

N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER

N-2-pyridinyl-β-Alanine,ethylester

ethyl (2R)-2-[(pyridin-2-yl)amino]propanoate

Ethyl-3-(pyridin-2yl-Amino)propionate

Ethyl-3-(pyridine-2-ylamino)propanoate

N-2-Pyridyl-beta-alanin ethyl ester

ethyl 3-(pyridin-2-ylamino)propanoate

ethyl (2S)-2-[(pyridin-2-yl)aMino]propanoate

3-(Pyridin-2-ylaMino)-propionic acid ethyl ester

Ethyl 3-(2-PyridylaMino)propanoate

N-Ethyl 3-(pyridin-2-ylaMino)propanoate

N-Pyridin-2-yl-beta-alanine ethyl ester

β-Alanine, N-2-pyridinyl-, ethyl ester

N-2-pyridinyl-, ethyl ester Alanine

Dabigatran Etexilate Intermdiate 4

Ethyl 3-(2-Pyridylamino)propionate

N-2-Pyridinyl-b-alanine ethyl ester

N-2-Pyridinyl-beta-alanine ethyl ester

3-(Pyridin-2-ylamino)propanoate

3-(2-Pyridylamino)propionic Acid Ethyl Ester

N-[2]PYRIDYL-B-ALANIN-ETHYL ESTER USP/EP/BP

Ethyl 3-(pyridin-2-ylamino)propan

Dabigatran Etexilate Impurity 90

N-2 pyridine -B- alanine ethyl ester

Ethyl 3-(pyridin-2-Ethyl 3-(pyridin-2-ylamino)propanoateylamino)propanoate

N-2-Pyridinyl-?-Alanineethylester (DBI1)

Ethyl 3-(Pyridin-2-ylamino)-propionoate

Ethyl N-(2-pyridyl)-3-aminopropionate

Ethyl-3-(pyridine-2yl amino)propane

N-2-pyridin-B-alanine ethyl ester

Dabigatran Impurity 83

Ethyl N-pyridin-2-yl-beta-alaninate

103041-38-9

103041-39-9

Intermediate of Dabigatran

For API's Production

Aromatics

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