2-Chloro-5-iodopyrimidine
Description- Product Name
- 2-Chloro-5-iodopyrimidine
- CAS No.
- 32779-38-7
- Chemical Name
- 2-Chloro-5-iodopyrimidine
- Synonyms
- 2-Cloro-5-Iodopyrimidine;Pyrimidine,2-chloro-5-iodo-;2-Chloro-5-iodopyrimidine,95%;2-Chloro-5-iodopyrimidine ISO 9001：2015 REACH
- CBNumber
- CB81041060
- Molecular Formula
- C4H2ClIN2
- Formula Weight
- 240.43
- MOL File
- 32779-38-7.mol
2-Chloro-5-iodopyrimidine Property
- Melting point:
- 133.0 to 137.0 °C
- Boiling point:
- 318℃
- Density
- 2.187
- Flash point:
- 146℃
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- form
- powder to crystal
- pka
- -2.78±0.22(Predicted)
- color
- White to Gray to Brown
- Sensitive
- Light Sensitive
- InChI
- InChI=1S/C4H2ClIN2/c5-4-7-1-3(6)2-8-4/h1-2H
- InChIKey
- WSZRCNZXKKTLQE-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC=C(I)C=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- SYX00335
- Product name
- 2-Chloro-5-iodopyrimidine
- Packaging
- 1g
- Price
- $179
- Updated
- 2025/07/31
- Product number
- C3119
- Product name
- 2-Chloro-5-iodopyrimidine
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $97
- Updated
- 2025/07/31
- Product number
- C368268
- Product name
- 2-Chloro-5-iodopyrimidine
- Packaging
- 500mg
- Price
- $75
- Updated
- 2021/12/16
- Product number
- J98109
- Product name
- 2-Chloro-5-iodopyrimidine
- Packaging
- 25g
- Price
- $80
- Updated
- 2021/12/16
- Product number
- 072113
- Product name
- 2-Chloro-5-iodopyrimidine
- Purity
- 95+%
- Packaging
- 5g
- Price
- $189
- Updated
- 2021/12/16
2-Chloro-5-iodopyrimidine Chemical Properties,Usage,Production
Description
2-Chloro-5-iodopyrimidine is 2-Chloro-5-iodopyridine is a halo-substituted pyridine, and it is used in biology application as synthesis intermediate in the multi-step synthesis.
Synthesis
1445-39-2
32779-38-7
Step A. Preparation of 2-chloro-5-iodopyrimidine To a stirred solution of 5-iodopyrimidin-2-amine (2.21 g, 10.0 mmol) in acetonitrile (20 mL) was sequentially added copper(II) chloride (2.02 g, 15 mmol) and tert-butyl nitrite (1.55 g, 15 mmol) at room temperature and under argon protection. The reaction mixture was transferred to an oil bath preheated to 60 °C and reacted under argon atmosphere. After completion of the reaction, the mixture was cooled to room temperature and diluted with the addition of ether (20 mL). The insoluble material was removed by filtration and the filtrate was concentrated under reduced pressure. The crude product was dissolved in a small amount of dichloromethane (about 2 mL) and purified by passing through an 80 g ISCO silica gel column using a 20 min gradient elution (0% to 100% ethyl acetate/hexane). 2-Chloro-5-iodopyrimidine (778 mg, 31% yield) was finally obtained as an off-white solid.1H NMR (400 MHz, CDCl3) δ 8.79 (s, 2H).
References
[1] Journal of Organic Chemistry, 2008, vol. 73, # 23, p. 9326 - 9333
[2] Patent: WO2010/9183, 2010, A1. Location in patent: Page/Page column 79
[3] Patent: US4248618, 1981, A
[4] Patent: WO2013/186692, 2013, A1. Location in patent: Page/Page column 62
2-Chloro-5-iodopyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
2-Chloro-5-iodopyrimidine Suppliers
- Tel
- +49 3493/605464
- Fax
- +49 3493/605470
- sales@intatrade.de
- Country
- Germany
- ProdList
- 3572
- Advantage
- 66
- Tel
- --
- Fax
- --
- info@activate-scientific.com
- Country
- Germany
- ProdList
- 2856
- Advantage
- 61
View Lastest Price from 2-Chloro-5-iodopyrimidine manufacturers
- Product
- 2-Chloro-5-iodopyrimidine 32779-38-7
- Price
- US $1.60-6.60/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-19
- Product
- 2-Chloro-5-iodopyrimidine 32779-38-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-06-04
- Product
- 2-Chloro-5-iodopyrimidine 32779-38-7
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98%min
- Supply Ability
- 30tons/month
- Release date
- 2023-02-22