Irsogladine maleate

Product Name: Irsogladine maleate
CAS No.: 84504-69-8
Chemical Name: Irsogladine maleate
Synonyms: Irgas;gaslon;mn-1695;Inomarl;Gasroil;Gaslon N;Irsogladin maleate;Irsogladine maleate;Maleate irsogladine;IrsogladineMaleate>
CBNumber: CB8105343
Molecular Formula: C13H11Cl2N5O4
Formula Weight: 372.16
MOL File: 84504-69-8.mol

More

Less

Irsogladine maleate Property

Melting point:: 181-182°C
storage temp.: Inert atmosphere,Room Temperature
Water Solubility: Insoluble in water
solubility: DMF:30.0(Max Conc. mg/mL);80.61(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);80.61(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.67(Max Conc. mM)
form: White crystalline powder.
color: White to Almost white
Merck: 14,5102
CAS DataBase Reference: 84504-69-8(CAS DataBase Reference)

More

Less

Safety

RTECS: XY5930000
HS Code: 2933.69.6050
Toxicity: LD50 in male, female mice, rats (mg/kg): 6035, 5697, 3898, 2917 orally; 2841, 3216, 1600, 1524 s.c.; 775, 1006, 558, 545 i.p. (Ueda, 1984 p 474)

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: I0719
Product name: Irsogladine Maleate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $81
Updated: 2024/03/01

TCI Chemical

Product number: I0719
Product name: Irsogladine Maleate
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $409
Updated: 2024/03/01

Cayman Chemical

Product number: 30223
Product name: Irsogladine (maleate)
Packaging: 50mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 30223
Product name: Irsogladine (maleate)
Packaging: 100mg
Price: $110
Updated: 2024/03/01

Cayman Chemical

Product number: 30223
Product name: Irsogladine (maleate)
Packaging: 250mg
Price: $182
Updated: 2024/03/01

More

Less

Irsogladine maleate Chemical Properties,Usage,Production

Description

Irsogladine is a gastroprotective agent. It increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced gap junction intercellular communication (GJIC). Irsogladine (3 mg/kg) inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats, effects that can be prevented by the nitric oxide synthase inhibitor L-NAME . It also inhibits superoxide anion production induced by fMLP and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to the phosphodiesterase 4 (PDE4) inhibitor rolipram .

Chemical Properties

White Solid

Uses

An anti-ulcer drug. Potent PDE4 inhibitor

Uses

antiulcerative;selective PDE4 inhibitor which also enhances gap junction intercellular communication

Definition

ChEBI: Irsogladine maleate is a dichlorobenzene.

Biological Activity

Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.

Irsogladine maleate Preparation Products And Raw materials

Raw materials

Preparation Products

Irsogladine

More

Less

Irsogladine maleate Suppliers

Americas 1 Brazil 1 Canada 4 China 181 Europe 3 France 1 Germany 2 India 6 Japan 5 South Korea 5 Switzerland 1 United Kingdom 12 United States 29 Global 251

Jiangxi Pharmaceutical Co., Ltd.

Tel: 0791-85985598
Email: zjlbgs@jxzhiyao.com
Country: China
ProdList: 5
Advantage: 58

Jiangxi ravel Biotechnology Co.,Ltd

Tel: 18502762009
Email: 721846333@qq.com
Country: China
ProdList: 2448
Advantage: 58

Shanghai Boyle Chemical Co., Ltd.

Tel
Fax: 86-21-57758967
Email: sales@boylechem.com
Country: China
ProdList: 2922
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40228
Advantage: 62

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15839
Advantage: 69

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6005
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44688
Advantage: 61

Zhejiang Jianfeng Haizhou Pharmaceutical Co., Ltd.

Tel: 0576-88221739
Fax: +86 (576) 88811295
Email: sales@haizhoupharm.com
Country: China
ProdList: 44
Advantage: 60

More

Less

View Lastest Price from Irsogladine maleate manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Irsogladine maleate 84504-69-8
Price: US $1.00-1.00/Kg/Bag
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-04-30

Sigma Audley

Product: Irsogladine maleate 84504-69-8
Price: US $35.00-25.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 200tons/year
Release date: 2024-03-15

Hebei Mojin Biotechnology Co., Ltd

Product: Diethyl 2-(4-chlorobenzamido)malonate 84504-69-8
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-20

84504-69-8, Irsogladine maleateRelated Search:

Disodium fumarate 6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine maleate Cinepazide maleate 1,3,5-Triazine Chlorphenamine maleate Maleic acid 3,4'-DIAMINODIPHENYLMETHANE Irsogladine Dichloromethylphenylsilane Dichlorodiphenylsilane Fumaric acid Enalapril maleate CIS-BUTENEDIOIC ANHYDRIDE Chlorobenzene Irsogladine maleate

2,4-diamino-6-(2,5-dichlorophenyl)-s-triazinemaleate

2,4-diamino-6-(2,5-dichlorophenyl)-s-triazinmaleate

3,5-triazine-2,4-diamine,6-(2,5-dichlorophenyl)-(z)-2-butenedioate(1:1)

gaslon

mn-1695

2,4-diamino-6-(2,5-dichlorophenyl)-1,3,5-triazine maleate

Irsogladin maleate

Gaslon N

Gasroil

Inomarl

Irgas

Irsogladine maleate

1,3,5-Triazine-2,4-diaMine,6-(2,5-dichlorophenyl)-, (2Z)-2-butenedioate (1:1)

Maleate irsogladine

6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diaMine (2Z)-2-Butenedioate

IrsogladineMaleate&gt

Irsogladine maleate USP/EP/BP

6-(2,5-Dichlorophenyl)-1,3,5-triazine-2,4-diamine maleate(1:1)

Irsogladine MaleateQ: What is Irsogladine Maleate Q: What is the CAS Number of Irsogladine Maleate Q: What is the storage condition of Irsogladine Maleate Q: What are the applications of Irsogladine Maleate

Irsogladine Maleate, ≥ 98.0%

84504-69-8

4504-69-8

C9H7Cl2N5C4H4O4

C13H11Cl2N5O4

C9H7Cl2N5C4H4O4C13H11Cl2N5O4

C9H7Cl2N5C4H4O4C

Amines

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals