Irsogladine maleate
- Product Name
- Irsogladine maleate
- CAS No.
- 84504-69-8
- Chemical Name
- Irsogladine maleate
- Synonyms
- Irgas;gaslon;mn-1695;Inomarl;Gasroil;Gaslon N;Irsogladin maleate;Irsogladine maleate;Maleate irsogladine;IrsogladineMaleate>
- CBNumber
- CB8105343
- Molecular Formula
- C13H11Cl2N5O4
- Formula Weight
- 372.16
- MOL File
- 84504-69-8.mol
Irsogladine maleate Property
- Melting point:
- 181-182°C
- storage temp.
- Inert atmosphere,Room Temperature
- Water Solubility
- Insoluble in water
- solubility
- DMF:30.0(Max Conc. mg/mL);80.61(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);80.61(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.67(Max Conc. mM) - form
- White crystalline powder.
- color
- White to Almost white
- Merck
- 14,5102
- InChI
- InChI=1S/C9H7Cl2N5.C4H4O4/c10-4-1-2-6(11)5(3-4)7-14-8(12)16-9(13)15-7;5-3(6)1-2-4(7)8/h1-3H,(H4,12,13,14,15,16);1-2H,(H,5,6)(H,7,8)/b;2-1-
- InChIKey
- PJLVTVAIERNDEQ-BTJKTKAUSA-N
- SMILES
- N1=C(C2=CC(Cl)=CC=C2Cl)N=C(N)N=C1N.C(O)(=O)/C=C\C(O)=O
- CAS DataBase Reference
- 84504-69-8(CAS DataBase Reference)
Safety
- RTECS
- XY5930000
- HS Code
- 2933.69.6050
- Toxicity
- LD50 in male, female mice, rats (mg/kg): 6035, 5697, 3898, 2917 orally; 2841, 3216, 1600, 1524 s.c.; 775, 1006, 558, 545 i.p. (Ueda, 1984 p 474)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- SML1521
- Product name
- Irsogladine maleate
- Purity
- ≥98% (HPLC)
- Packaging
- 50 mg
- Price
- $90.1
- Updated
- 2025/07/31
- Product number
- I0719
- Product name
- Irsogladine Maleate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $76
- Updated
- 2025/07/31
- Product number
- I0719
- Product name
- Irsogladine Maleate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $384
- Updated
- 2025/07/31
- Product number
- 30223
- Product name
- Irsogladine (maleate)
- Packaging
- 50mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 30223
- Product name
- Irsogladine (maleate)
- Packaging
- 100mg
- Price
- $110
- Updated
- 2024/03/01
Irsogladine maleate Chemical Properties,Usage,Production
Description
Irsogladine is a gastroprotective agent. It increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced gap junction intercellular communication (GJIC). Irsogladine (3 mg/kg) inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats, effects that can be prevented by the nitric oxide synthase inhibitor L-NAME . It also inhibits superoxide anion production induced by fMLP and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to the phosphodiesterase 4 (PDE4) inhibitor rolipram .
Chemical Properties
White Solid
Uses
An anti-ulcer drug. Potent PDE4 inhibitor
Uses
antiulcerative;selective PDE4 inhibitor which also enhances gap junction intercellular communication
Definition
ChEBI: Irsogladine maleate is a dichlorobenzene.
Biological Activity
Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.
References
[1] TAKASHI KYOI. Irsogladine prevents monochloramine-induced gastric mucosal lesions by improving the decrease in mucosal blood flow due to the disturbance of nitric oxide synthesis in rats.[J]. Journal of pharmacological sciences, 2003, 93 3: 314-320. DOI: 10.1254/jphs.93.314
[2] F UEDA T I K Ban. Irsogladine activates gap-junctional intercellular communication through M1 muscarinic acetylcholine receptor.[J]. Journal of Pharmacology and Experimental Therapeutics, 1995, 274 2: 815-819.
[3] TAKASHI KYOI. Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils[J]. Life sciences, 2004, 76 1: Pages 71-83. DOI: 10.1016/j.lfs.2004.06.016
Irsogladine maleate Preparation Products And Raw materials
Raw materials
Preparation Products
Irsogladine maleate Suppliers
- Tel
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- Country
- France
- ProdList
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- Advantage
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View Lastest Price from Irsogladine maleate manufacturers
- Product
- Irsogladine maleate 84504-69-8
- Price
- US $1.00-1.00/Kg/Bag
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-04-30
- Product
- Irsogladine maleate 84504-69-8
- Price
- US $35.00-25.00/kg
- Min. Order
- 1kg
- Purity
- 99.8%
- Supply Ability
- 200tons/year
- Release date
- 2024-03-15
- Product
- Irsogladine maleate 84504-69-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10