Irsogladine maleate
- Product Name
- Irsogladine maleate
- CAS No.
- 84504-69-8
- Chemical Name
- Irsogladine maleate
- Synonyms
- Irgas;gaslon;mn-1695;Inomarl;Gasroil;Gaslon N;Irsogladin maleate;Irsogladine maleate;Maleate irsogladine;IrsogladineMaleate>
- CBNumber
- CB8105343
- Molecular Formula
- C13H11Cl2N5O4
- Formula Weight
- 372.16
- MOL File
- 84504-69-8.mol
Irsogladine maleate Property
- Melting point:
- 181-182°C
- storage temp.
- Inert atmosphere,Room Temperature
- Water Solubility
- Insoluble in water
- solubility
- DMF:30.0(Max Conc. mg/mL);80.61(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);80.61(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.67(Max Conc. mM) - form
- White crystalline powder.
- color
- White to Almost white
- Merck
- 14,5102
- CAS DataBase Reference
- 84504-69-8(CAS DataBase Reference)
Safety
- RTECS
- XY5930000
- HS Code
- 2933.69.6050
- Toxicity
- LD50 in male, female mice, rats (mg/kg): 6035, 5697, 3898, 2917 orally; 2841, 3216, 1600, 1524 s.c.; 775, 1006, 558, 545 i.p. (Ueda, 1984 p 474)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- I0719
- Product name
- Irsogladine Maleate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 1g
- Price
- $81
- Updated
- 2024/03/01
- Product number
- I0719
- Product name
- Irsogladine Maleate
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $409
- Updated
- 2024/03/01
- Product number
- 30223
- Product name
- Irsogladine (maleate)
- Packaging
- 50mg
- Price
- $73
- Updated
- 2024/03/01
- Product number
- 30223
- Product name
- Irsogladine (maleate)
- Packaging
- 100mg
- Price
- $110
- Updated
- 2024/03/01
- Product number
- 30223
- Product name
- Irsogladine (maleate)
- Packaging
- 250mg
- Price
- $182
- Updated
- 2024/03/01
Irsogladine maleate Chemical Properties,Usage,Production
Description
Irsogladine is a gastroprotective agent. It increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced gap junction intercellular communication (GJIC). Irsogladine (3 mg/kg) inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats, effects that can be prevented by the nitric oxide synthase inhibitor L-NAME . It also inhibits superoxide anion production induced by fMLP and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to the phosphodiesterase 4 (PDE4) inhibitor rolipram .
Chemical Properties
White Solid
Uses
An anti-ulcer drug. Potent PDE4 inhibitor
Uses
antiulcerative;selective PDE4 inhibitor which also enhances gap junction intercellular communication
Definition
ChEBI: Irsogladine maleate is a dichlorobenzene.
Biological Activity
Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.
Irsogladine maleate Preparation Products And Raw materials
Raw materials
Preparation Products
Irsogladine maleate Suppliers
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- +1 416 493 6870
- Fax
- +1 416 499 9759
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- Canada
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View Lastest Price from Irsogladine maleate manufacturers
- Product
- Irsogladine maleate 84504-69-8
- Price
- US $1.00-1.00/Kg/Bag
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 50tons
- Release date
- 2020-04-30
- Product
- Irsogladine maleate 84504-69-8
- Price
- US $35.00-25.00/kg
- Min. Order
- 1kg
- Purity
- 99.8%
- Supply Ability
- 200tons/year
- Release date
- 2024-03-15
- Product
- Diethyl 2-(4-chlorobenzamido)malonate 84504-69-8
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-09-20