Irsogladine maleate

ChemicalBook > CAS DataBase List > Irsogladine maleate

Product Name: Irsogladine maleate
CAS No.: 84504-69-8
Chemical Name: Irsogladine maleate
Synonyms: Irgas;gaslon;mn-1695;Inomarl;Gasroil;Gaslon N;Irsogladin maleate;Irsogladine maleate;Maleate irsogladine;IrsogladineMaleate>
CBNumber: CB8105343
Molecular Formula: C13H11Cl2N5O4
Formula Weight: 372.16
MOL File: 84504-69-8.mol

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Irsogladine maleate Property

Melting point:: 181-182°C
storage temp.: Inert atmosphere,Room Temperature
Water Solubility: Insoluble in water
solubility: DMF:30.0(Max Conc. mg/mL);80.61(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);80.61(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.67(Max Conc. mM)
form: White crystalline powder.
color: White to Almost white
Merck: 14,5102
CAS DataBase Reference: 84504-69-8(CAS DataBase Reference)

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Safety

RTECS: XY5930000
HS Code: 2933.69.6050
Toxicity: LD50 in male, female mice, rats (mg/kg): 6035, 5697, 3898, 2917 orally; 2841, 3216, 1600, 1524 s.c.; 775, 1006, 558, 545 i.p. (Ueda, 1984 p 474)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TCI Chemical

Product number: I0719
Product name: Irsogladine Maleate
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $81
Updated: 2024/03/01

TCI Chemical

Product number: I0719
Product name: Irsogladine Maleate
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $409
Updated: 2024/03/01

Cayman Chemical

Product number: 30223
Product name: Irsogladine (maleate)
Packaging: 50mg
Price: $73
Updated: 2024/03/01

Cayman Chemical

Product number: 30223
Product name: Irsogladine (maleate)
Packaging: 100mg
Price: $110
Updated: 2024/03/01

Cayman Chemical

Product number: 30223
Product name: Irsogladine (maleate)
Packaging: 250mg
Price: $182
Updated: 2024/03/01

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Irsogladine maleate Chemical Properties,Usage,Production

Description

Irsogladine is a gastroprotective agent. It increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced gap junction intercellular communication (GJIC). Irsogladine (3 mg/kg) inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats, effects that can be prevented by the nitric oxide synthase inhibitor L-NAME . It also inhibits superoxide anion production induced by fMLP and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to the phosphodiesterase 4 (PDE4) inhibitor rolipram .

Chemical Properties

White Solid

Uses

An anti-ulcer drug. Potent PDE4 inhibitor

Uses

antiulcerative;selective PDE4 inhibitor which also enhances gap junction intercellular communication

Definition

ChEBI: Irsogladine maleate is a dichlorobenzene.

Biological Activity

Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.

Irsogladine maleate Preparation Products And Raw materials

Raw materials

Preparation Products

Irsogladine

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View Lastest Price from Irsogladine maleate manufacturers

Sigma Audley

Product: Irsogladine maleate 84504-69-8
Price: US $35.00-25.00/kg
Min. Order: 1kg
Purity: 99.8%
Supply Ability: 200tons/year
Release date: 2024-03-15

Hebei Duling International Trade Co. LTD

Product: Irsogladine maleate 84504-69-8
Price: US $24.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 5000 tons
Release date: 2023-02-01

Shaanxi Dideu Medichem Co. Ltd

Product: Irsogladine maleate 84504-69-8
Price: US $1.00-1.00/Kg/Bag
Min. Order: 1g
Purity: 99%
Supply Ability: 50tons
Release date: 2020-04-30

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Irsogladine MaleateQ: What is Irsogladine Maleate Q: What is the CAS Number of Irsogladine Maleate Q: What is the storage condition of Irsogladine Maleate Q: What are the applications of Irsogladine Maleate

Irsogladine Maleate, ≥ 98.0%

84504-69-8

4504-69-8

C9H7Cl2N5C4H4O4

C13H11Cl2N5O4

C9H7Cl2N5C4H4O4C13H11Cl2N5O4

C9H7Cl2N5C4H4O4C

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