ChemicalBook > CAS DataBase List > Irsogladine maleate

Irsogladine maleate

Product Name
Irsogladine maleate
CAS No.
84504-69-8
Chemical Name
Irsogladine maleate
Synonyms
Irgas;gaslon;mn-1695;Inomarl;Gasroil;Gaslon N;Irsogladin maleate;Irsogladine maleate;Maleate irsogladine;IrsogladineMaleate>
CBNumber
CB8105343
Molecular Formula
C13H11Cl2N5O4
Formula Weight
372.16
MOL File
84504-69-8.mol
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Irsogladine maleate Property

Melting point:
181-182°C
storage temp. 
Inert atmosphere,Room Temperature
Water Solubility 
Insoluble in water
solubility 
DMF:30.0(Max Conc. mg/mL);80.61(Max Conc. mM)
DMSO:30.0(Max Conc. mg/mL);80.61(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.67(Max Conc. mM)
form 
White crystalline powder.
color 
White to Almost white
Merck 
14,5102
InChI
InChI=1S/C9H7Cl2N5.C4H4O4/c10-4-1-2-6(11)5(3-4)7-14-8(12)16-9(13)15-7;5-3(6)1-2-4(7)8/h1-3H,(H4,12,13,14,15,16);1-2H,(H,5,6)(H,7,8)/b;2-1-
InChIKey
PJLVTVAIERNDEQ-BTJKTKAUSA-N
SMILES
N1=C(C2=CC(Cl)=CC=C2Cl)N=C(N)N=C1N.C(O)(=O)/C=C\C(O)=O
CAS DataBase Reference
84504-69-8(CAS DataBase Reference)
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Safety

RTECS 
XY5930000
HS Code 
2933.69.6050
Toxicity
LD50 in male, female mice, rats (mg/kg): 6035, 5697, 3898, 2917 orally; 2841, 3216, 1600, 1524 s.c.; 775, 1006, 558, 545 i.p. (Ueda, 1984 p 474)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1521
Product name
Irsogladine maleate
Purity
≥98% (HPLC)
Packaging
50 mg
Price
$90.1
Updated
2025/07/31
TCI Chemical
Product number
I0719
Product name
Irsogladine Maleate
Purity
>98.0%(HPLC)(T)
Packaging
1g
Price
$76
Updated
2025/07/31
TCI Chemical
Product number
I0719
Product name
Irsogladine Maleate
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$384
Updated
2025/07/31
Cayman Chemical
Product number
30223
Product name
Irsogladine (maleate)
Packaging
50mg
Price
$73
Updated
2024/03/01
Cayman Chemical
Product number
30223
Product name
Irsogladine (maleate)
Packaging
100mg
Price
$110
Updated
2024/03/01
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Irsogladine maleate Chemical Properties,Usage,Production

Description

Irsogladine is a gastroprotective agent. It increases transfer of Lucifer yellow CH between isolated rabbit gastric epithelial cells, indicating enhanced gap junction intercellular communication (GJIC). Irsogladine (3 mg/kg) inhibits gastric mucosal lesion formation and decreases in gastric mucosal blood flow induced by monochloramine in rats, effects that can be prevented by the nitric oxide synthase inhibitor L-NAME . It also inhibits superoxide anion production induced by fMLP and increases cAMP levels in isolated human neutrophils in a concentration-dependent manner, similar to the phosphodiesterase 4 (PDE4) inhibitor rolipram .

Chemical Properties

White Solid

Uses

An anti-ulcer drug. Potent PDE4 inhibitor

Uses

antiulcerative;selective PDE4 inhibitor which also enhances gap junction intercellular communication

Definition

ChEBI: Irsogladine maleate is a dichlorobenzene.

Biological Activity

Phosphodiesterase 4 (PDE4) inhibitor that displays gastroprotective properties. Prevents gastric mucosal injury induced by monochloramine and ischemia-reperfusion. Activates gap-junctional intercellular communication improving gastric mucosal barrier function. Inhibits superoxide production in human neutrophils and inhibits in vitro and in vivo angiogenesis.

References

[1] TAKASHI KYOI. Irsogladine prevents monochloramine-induced gastric mucosal lesions by improving the decrease in mucosal blood flow due to the disturbance of nitric oxide synthesis in rats.[J]. Journal of pharmacological sciences, 2003, 93 3: 314-320. DOI: 10.1254/jphs.93.314
[2] F UEDA  T I  K Ban. Irsogladine activates gap-junctional intercellular communication through M1 muscarinic acetylcholine receptor.[J]. Journal of Pharmacology and Experimental Therapeutics, 1995, 274 2: 815-819.
[3] TAKASHI KYOI. Irsogladine, an anti-ulcer drug, suppresses superoxide production by inhibiting phosphodiesterase type 4 in human neutrophils[J]. Life sciences, 2004, 76 1: Pages 71-83. DOI: 10.1016/j.lfs.2004.06.016

Irsogladine maleate Preparation Products And Raw materials

Raw materials

Preparation Products

Irsogladine
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Irsogladine maleate Suppliers

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View Lastest Price from Irsogladine maleate manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
Irsogladine maleate 84504-69-8
Price
US $1.00-1.00/Kg/Bag
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-04-30
Sigma Audley
Product
Irsogladine maleate 84504-69-8
Price
US $35.00-25.00/kg
Min. Order
1kg
Purity
99.8%
Supply Ability
200tons/year
Release date
2024-03-15
Zhuozhou Wenxi import and Export Co., Ltd
Product
Irsogladine maleate 84504-69-8
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

84504-69-8, Irsogladine maleateRelated Search:

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