ChemicalBook > CAS DataBase List > Pamidronic acid

Pamidronic acid

Product Name
Pamidronic acid
CAS No.
40391-99-9
Chemical Name
Pamidronic acid
Synonyms
DLV;AHPrBP;Panolin;amidronate;Rescriptor;Pamidronicaci;PAMIDRONIC ACID;Iflab-bb F1977-0047;Delavirdine mesylate;Ibandronate Impurity 23
CBNumber
CB8107554
Molecular Formula
C3H11NO7P2
Formula Weight
235.07
MOL File
40391-99-9.mol
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Pamidronic acid Property

Melting point:
226-228°C
Boiling point:
658.7±65.0 °C(Predicted)
Density 
1.998±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
Methanol (Very Slightly, Heated, Sonicated), Water (Slightly, Heated, Sonicated)
pka
1.44±0.10(Predicted)
form 
Solid
color 
Light Brown to Beige
Stability:
Hygroscopic
InChI
InChI=1S/C3H11NO7P2/c4-2-1-3(5,12(6,7)8)13(9,10)11/h5H,1-2,4H2,(H2,6,7,8)(H2,9,10,11)
InChIKey
WRUUGTRCQOWXEG-UHFFFAOYSA-N
SMILES
C(P(=O)(O)O)(P(=O)(O)O)(O)CCN
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Safety

HS Code 
9999999999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris
Product number
4149
Product name
Delavirdine mesylate
Purity
≥99%(HPLC)
Packaging
50
Price
$634
Updated
2021/12/16
TRC
Product number
P172490
Product name
PamidronicAcid
Packaging
50mg
Price
$105
Updated
2021/12/16
Usbiological
Product number
462007
Product name
Pamidronic Acid
Packaging
50mg
Price
$368
Updated
2021/12/16
ChemScene
Product number
CS-7787
Product name
Pamidronicacid
Purity
≥98.0%
Packaging
50mg
Price
$96
Updated
2021/12/16
AK Scientific
Product number
2631AH
Product name
Pamidronicacid
Packaging
1g
Price
$158
Updated
2021/12/16
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Pamidronic acid Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Aredia,Novartis,India

Uses

A biphosphonate bone resorption inhibitor.

Uses

anticancer

Definition

ChEBI: Pamidronate is a phosphonoacetic acid.

Manufacturing Process

For a batch size of 5 L, 587.5 g (3.2 moles) of mannitol is dissolved in 3.5 L of water. Pamidronic acid (31.6 g, 0.133 moles) is mixed with a 1.0 L aliquot of the mannitol solution to form a slurry. The slurry is then transferred into the remainder of the mannitol solution, and stirred for at least 15 min. Aqueous 1 N sodium hydroxide (270 ml) is then added and the mixture is stirred until a clear, colorless solution results. The pH is then adjusted to 6.50.1 using either 1 M aqueous phosphoric acid or 1 N aqueous sodium hydroxide, as needed. The solution is then filtered through a 0.22 micron filter, and filled at 20°C into vials at 4.0 ml (4.172 g)/vial, under sterile conditions. The aqueous solution is frozen at -37°C and lyophilized (20 mbar, 20°-40°C) to yield 1,250 vials, each containing 30 mg of amorphous disodium pamidronate. The vials are sealed under positive nitrogen pressure. The disodium pamidronate is amorphous (noncrystalline) by X-ray diffraction and contains 0.7 wt-% water.

brand name

Rescriptor (Agouron).

Therapeutic Function

Bone resorption suppressant

References

[1] Patent: WO2016/199111, 2016, A1. Location in patent: Paragraph 00134-00135
[2] Patent: US10081572, 2018, B2. Location in patent: Page/Page column 9
[3] Russian Journal of Bioorganic Chemistry, 2012, vol. 38, # 2, p. 224 - 229
[4] Letters in Drug Design and Discovery, 2016, vol. 13, # 6, p. 475 - 478
[5] Letters in Drug Design and Discovery, 2016, vol. 13, # 6, p. 475 - 478

Pamidronic acid Preparation Products And Raw materials

Raw materials

β-Alanine Phosphorus trichloride Disodium pamidronate Activated carbon,decolor

Preparation Products

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Pamidronic acid Suppliers

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View Lastest Price from Pamidronic acid manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Pamidronic acid 40391-99-9
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
10kg/month
Release date
2021-06-21
Dideu Industries Group Limited
Product
Pamidronic acid 40391-99-9
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-07-28

40391-99-9, Pamidronic acid Related Search:

Imatinib Lithium bis(trimethylsilyl)amide Stearic acid DELAVIRDINE Zoledronic acid Cyclamic acid Molasses Ethyl 2-(Chlorosulfonyl)acetate Folic acid N-Pentyl-β-alanine Citric acid Ascoric Acid Ibandronate sodium monohydrate Olpadronate Sodium methyl N-(3-methoxy-3-oxopropyl)-N-methyl-beta-alaninate Trisodium phosphate Acryloyl chloride N-Methylpentylamine

  • PAMIDRONIC ACID
  • PAMIDRONIC ACID SODIUM SALT
  • Rescriptor
  • amidronate
  • DLV
  • (3-amino-1-hydroxypropylidene)bisphosphonic acid
  • (3-Amino-1-hydroxypropylidene)diphosphonic acid
  • 3-AMINO-1-HYDROXY-1,1-PROPANEDIPHOSPHONIC ACID
  • Delavirdine mesylate
  • AHPrBP
  • (3-Amino-1-hydroxypropylidene)-1,1-bisphosphonate
  • 3-Amino-1-hydroxypropane-1,1-diphosphonic acid
  • Panolin
  • Propane-1-hydroxy-3-amino-1,1-diphosphonic acid
  • [2-Aminoethyl(hydroxy)methylene]bisphosphonic acid
  • 1-Hydroxy-3-aminopropylidenebis(phosphonic acid)
  • 1-Hydroxy-3-aminopropylidenebisphosphonic acid
  • Iflab-bb F1977-0047
  • PaMidronic acid(Delavirdine Mesylate,Rescriptor)
  • (3-amino-1-hydroxypropane-1,1-diyl)diphosphonic acid
  • Ibandronate Impurity 23
  • Pamidronic acid-d3 major
  • Pamidronicaci
  • Pamidronic acid USP/EP/BP
  • Phosphonic acid, P,P'-(3-amino-1-hydroxypropylidene)bis-
  • (3-Amino-1-hydroxypropane-1,1-diyl)bis(phosphonic acid)
  • 40391-99-9
  • C3H11NO7P2
  • C3H19NNa2O7P2
  • (intermediate of pamidronate disodium)
  • Delavirdine
  • API