(R)-(-)-1-Benzyl-3-hydroxypiperidine

Product Name: (R)-(-)-1-Benzyl-3-hydroxypiperidine
CAS No.: 91599-81-4
Chemical Name: (R)-(-)-1-Benzyl-3-hydroxypiperidine
Synonyms: (R)-1-BENZYL-3-PIPERIDINOL;(R)-1-BENZYL-PIPERIDIN-3-OL;(R)-1-Benzyl-3-hydroxypiperidi;)-1-Benzyl-3-hydroxypiperidinol;(R)-1-BENZYL-3-HYDROXYPIPERIDINE;(R)-N-BENZYL-3-HYDROXYPIPERIDINE;(R)-1-(PhenylMethyl)-3-piperidinol;(R)-1-N-BENZYL-3-HYDROXY-PIPERIDINE;(R)-(-)-1-BENZYL-3-HYDROXYPIPERIDINE;(R)-1-Benzyl-3-hydroxypiperidine >
CBNumber: CB8108748
Molecular Formula: C12H17NO
Formula Weight: 191.27
MOL File: 91599-81-4.mol

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(R)-(-)-1-Benzyl-3-hydroxypiperidine Property

Boiling point:: 275 °C (lit.)
alpha: -12 º (C=1 IN MEOH)
Density: 1.07 g/mL at 25 °C (lit.)
refractive index: n20/D 1.547(lit.)
Flash point:: >230 °F
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: clear liquid
pka: 14.82±0.20(Predicted)
color: Light orange to Yellow to Green
optical activity: [α]24/D 12°, c = 1 in methanol
InChI: InChI=1S/C12H17NO/c14-12-7-4-8-13(10-12)9-11-5-2-1-3-6-11/h1-3,5-6,12,14H,4,7-10H2/t12-/m1/s1
InChIKey: UTTCOAGPVHRUFO-GFCCVEGCSA-N
SMILES: N1(CC2=CC=CC=C2)CCC[C@@H](O)C1
CAS DataBase Reference: 91599-81-4(CAS DataBase Reference)

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Safety

Hazard Codes: T
Risk Statements: 25-36/37/38
Safety Statements: 26-45
RIDADR: UN 2810 6.1/PG 3
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 455172
Product name: (R)-(?)-1-Benzyl-3-hydroxypiperidine
Purity: 97%
Packaging: 5g
Price: $199
Updated: 2023/01/07

TCI Chemical

Product number: B4857
Product name: (R)-1-Benzyl-3-hydroxypiperidine
Purity: >98.0%(GC)
Packaging: 1g
Price: $64
Updated: 2024/03/01

TCI Chemical

Product number: B4857
Product name: (R)-1-Benzyl-3-hydroxypiperidine
Purity: >98.0%(GC)
Packaging: 5g
Price: $194
Updated: 2024/03/01

TRC

Product number: B288655
Product name: (R)-1-Benzyl-3-piperidinol
Packaging: 100mg
Price: $1230
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB55338
Product name: (R)-1-Benzyl-3-hydroxypiperidine
Packaging: 25g
Price: $1300
Updated: 2021/12/16

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(R)-(-)-1-Benzyl-3-hydroxypiperidine Chemical Properties,Usage,Production

Uses

(R)-1-Benzyl-3-piperidinol is a benzylpiperidine derivative with hypotensive affects. (R)-1-Benzyl-3-piperidinol is used in the preparation of in vivo probes for measuring endogenous acetylcholine lev els.

Synthesis

40114-49-6

91599-81-4

General procedure for the synthesis of (R)-(-)-1-benzyl-3-hydroxypiperidine using 1-benzyl-3-piperidone as starting material: a reaction mixture was prepared in 1 mL of potassium phosphate buffer (100 mM, pH 7.0) containing 200 mM 1-benzyl-3-piperidone, 1 mM NAD+, 5% (v/v) 2-propanol, and 10 mg of the crude enzyme READH. The reaction mixture warmed at 50°C. For ChKRED20, the reaction conditions were adjusted to 40% (v/v) 2-propanol and 40 °C reaction temperature. The reaction progress was monitored by TLC and the reaction was terminated by extraction with 1 mL of methyl tert-butyl ether. The organic phase was dried with anhydrous sodium sulfate and concentrated. The conversion and enantiomeric excess were determined by chiral HPLC. The products were purified by silica gel column chromatography and structurally characterized by NMR analysis, spinometry and mass spectrometry.

References

[1] Process Biochemistry, 2017, vol. 56, p. 90 - 97

(R)-(-)-1-Benzyl-3-hydroxypiperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-(-)-1-Benzyl-3-hydroxypiperidine Suppliers

Americas 1 Belgium 1 Canada 3 China 90 Europe 3 France 1 Germany 6 India 3 Japan 1 Slovakia 1 Switzerland 1 United Kingdom 10 United States 36 Global 157

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View Lastest Price from (R)-(-)-1-Benzyl-3-hydroxypiperidine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: (R)-(-)-1-Benzyl-3-hydroxypiperidine 91599-81-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-19

Career Henan Chemical Co

Product: (R)-(-)-1-Benzyl-3-hydroxypiperidine 91599-81-4
Price: US $1.80-3.60/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 88KG
Release date: 2019-09-04

91599-81-4, (R)-(-)-1-Benzyl-3-hydroxypiperidineRelated Search:

3-Hydroxypiperidine DROPERIDOL Benzyl benzoate Benzyl acetate Haloperidol Benzoyl peroxide Benzyl alcohol Benzyltriethylammonium chloride Benzyl chloride Benzyltrimethylammonium chloride Diphenoxylate Benidipine hydrochloride Benzyl Benidipine 1-BENZYL-3-HYDROXYPIPERIDINE HYDROCHLORIDE benzyl 3-hydroxypiperidine-1-carboxylate BENZYL 4-HYDROXYPIPERIDINE-1-CARBOXYLATE N-BENZYL-3-HYDROXYPIPERIDINE,1-BENZYL-3-HYDROXYPIPERIDINE,1-BENZYL-3-HYDROXYPIPERIDINE 98%

3-PIPERIDINOL, 1-(PHENYLMETHYL)-, (3R)-

(R)-1-BENZYL-PIPERIDIN-3-OL

(R)-1-N-BENZYL-3-HYDROXY-PIPERIDINE

(R)-(-)-1-BENZYL-3-HYDROXYPIPERIDINE

(R)-1-BENZYL-3-HYDROXYPIPERIDINE

(R)-1-BENZYL-3-PIPERIDINOL

(R)-N-BENZYL-3-HYDROXYPIPERIDINE

(R)-(-)-1-BENZYL-3-HYDROXYPIPERIDINE, 97 %

(R)-(-)-1-Benzyl-3-hydroxypiperidinol

(R)-1-Benzyl-3-hydroxypiperidi

(R)-1-(PhenylMethyl)-3-piperidinol

)-1-Benzyl-3-hydroxypiperidinol

(R)-1-Benzyl-3-hydroxypiperidine &gt

(<i>R</i>)-(?)-1-Benzyl-3-hydroxypiperidine

91599-81-4

91599-82-4

Chiral Building Blocks

Asymmetric Synthesis

Piperidines

Heterocyclic Building Blocks

(intermediate of benidipine)