10-Hydroxy-2-decenoic acid

Product Name: 10-Hydroxy-2-decenoic acid
CAS No.: 14113-05-4
Chemical Name: 10-Hydroxy-2-decenoic acid
Synonyms: 10-HAD;10-HDA;10H2DA;jelly acid;Queenbeeaci;QUEEN BEE ACID;Queen been acid;ROYAL JELLY ACID;hydroxy-decenouc acid;10-HYDROXYDECENOIC ACID
CBNumber: CB8109967
Molecular Formula: C10H18O3
Formula Weight: 186.25
MOL File: 14113-05-4.mol

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10-Hydroxy-2-decenoic acid Property

Melting point:: 64.0 to 68.0 °C
Boiling point:: 339.2±15.0 °C(Predicted)
Density: 1.038±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml
form: powder to crystal
pka: 4.78±0.10(Predicted)
color: White to Almost white
LogP: 1.808 (est)
CAS DataBase Reference: 14113-05-4(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
HS Code: 29181990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3381
Product name: 10-Hydroxy-trans-2-decenoic acid
Purity: ≥98% (HPLC)
Packaging: 10MG
Price: $86.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3381
Product name: 10-Hydroxy-trans-2-decenoic acid
Purity: ≥98% (HPLC)
Packaging: 50MG
Price: $350
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHL89223
Product name: 10-Hydroxy-trans-2-decenoic acid
Purity: phyproof? Reference Substance
Packaging: 10mg
Price: $608
Updated: 2024/03/01

TCI Chemical

Product number: H1337
Product name: trans-10-Hydroxy-2-decenoic Acid
Purity: >97.0%(GC)(T)
Packaging: 200mg
Price: $72
Updated: 2024/03/01

TCI Chemical

Product number: H1337
Product name: trans-10-Hydroxy-2-decenoic Acid
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $252
Updated: 2024/03/01

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10-Hydroxy-2-decenoic acid Chemical Properties,Usage,Production

Description

10-HDA is an unsaturated fatty acid found in royal jelly produced from the hypopharyngeal and mandibular gland secretions of honeybees. 10-HDA has longevity-promoting effects in C. elegans at a concentration of 25 μM. It down-regulates matrix metalloproteinases (MMPs) in rheumatoid arthritis synovial fibroblasts at a concentration of 1.25 nM and inhibits VEGF-induced angiogenesis in HUVECs at 500 μM. 10-HDA also facilitates differentiation of neurons from neural stem/progenitor cells and promotes collagen production by skin fibroblasts at concentrations of 100 μM and 1.5 mM, respectively.

Uses

10-Hydroxy-2-decenoic acid has antiseptic, anti-inflammatory, anti-obesity, anti-aging, preventing bone loss and anti-tumour pharmacological effects, with potential therapeutic effects for postmenopausal osteoporosis, as well as benefiting the human gastrointestinal tract^[1-3].

Definition

ChEBI: (E)-10-hydroxydec-2-enoic acid is an omega-hydroxy amino acid that is 2-decenoic acid in which one of the hydrogens attached to the terminal carbon is replaced by a hydroxy group and in which the C=C double bond has E configuration. It is a component of royal jelly. It has a role as an animal metabolite and a geroprotector. It is an alpha,beta-unsaturated monocarboxylic acid, a straight-chain fatty acid, a hydroxy monounsaturated fatty acid and an omega-hydroxy-medium-chain fatty acid.

Biological Activity

10-Hydroxy-2-decenoic acid is an orally available royal jelly component that potently inhibits osteoclastogenesis. It binds to free fatty acid receptor 4 (FFAR4) on osteoclasts which inhibits RANKL (receptor activator of nuclear factor-κB (NF-κB) ligand), thereby attenuating the induction of nuclear factor of activated T cells (NFAT) c1. 10-Hydroxy-2-decenoic acid inhibits bone resorption in ovariectomized mice.
The production of pro-inflammatory cytokines, Interleukin (IL)-8, IL-1β and tumor necrosis factor-alpha (TNF-α) in WiDr cells was modulated by 10-HDA. IL-8 were dramatically declined by 10-HDA at 3 mM, while IL-1β and TNF-α were significantly decreased. 10-HDA increased IL-1ra in a dose manner. NF-κB pathway is primarily in response to prototypical pro-inflammatory cytokines, and NF-κB was reduced after 10-HDA treatment. 10-HDA acted as potent bactericide against animal- or human-specific pathogens, including Staphylococcus aureus, Streptococcus alactolyticus, Staphylococcus intermedius B, Staphylococcus xylosus, Salmonella cholearasuis, Vibro parahaemolyticus and Escherichia coli (hemolytic)^[1].

References

[1] YUAN-CHANG YANG. 10-hydroxy-2-decenoic acid of royal jelly exhibits bactericide and anti-inflammatory activity in human colon cancer cells.[J]. BMC Complementary and Alternative Medicine, 2018: 202. DOI:10.1186/s12906-018-2267-9.
[2] YOKO HONDA. 10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling.[J]. Journal of Aging Research, 2015, 2015: 425261. DOI:10.1155/2015/425261.
[3] YOSUKE TSUCHIYA. The key royal jelly component 10-hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4.[J]. The Journal of Biological Chemistry, 2020, 295 34: 12224-12232. DOI:10.1074/jbc.RA120.013821.

10-Hydroxy-2-decenoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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10-Hydroxy-2-decenoic acid Suppliers

Americas 1 China 333 Europe 1 Germany 1 India 3 Japan 3 Sweden 1 Ukraine 1 United Kingdom 4 United States 30 Global 378

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View Lastest Price from 10-Hydroxy-2-decenoic acid manufacturers

Hebei Guanlang Biotechnology Co., Ltd.

Product: 10-Hydroxy-2-decenoic acid 14113-05-4
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-08-23

Hebei Duling International Trade Co. LTD

Product: 10-Hydroxy-2-decenoic acid 14113-05-4
Price: US $50.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50 tons
Release date: 2023-04-13

Hebei Longbang Technology Co., Ltd

Product: 10-Hydroxy-2-decenoic acid 14113-05-4
Price: US $6.00/kg
Min. Order: 1kg
Purity: More than 99%
Supply Ability: 2000KG/Month
Release date: 2024-05-10

14113-05-4, 10-Hydroxy-2-decenoic acid Related Search:

HYDROXY-2-DECENOIC ACID, (E)-10-(10-HDA)(P)

hydroxy-decenouc acid

jelly acid

trans-10-Hydroxy-2-decenoic Acid

(E)-10-hydroxydec-2-enoic acid

Queen been acid

10-HAD,10-hydroxydec-2-enoic acid

OMEGA-HYDROXY C10:1 (2-TRANS)

ROYAL JELLY ACID

QUEEN BEE ACID

(E)-10-HYDROXY-2-DECENOIC ACID

HYDROXY-2-DECENOIC ACID, (E)-10-

10-Hydroxydecylenic acid

ω-Hydroxy-Δ2-decenoic acid

10-HYDROXYDECENOIC ACID

10-HYDROXY-2-(E)-DECENOIC ACID

10-HYDROXY-2TR-DECENOIC ACID

10-HAD

10-HDA

10-HYDROXY-2-DECENOIC ACID (10-HAD)

10-Hydroxy-2tr-Decenoic?Acid?(Royal?Jelly?Acid)?

10-HYDROXY-2-DECENOIC ACID (10HDA)

HYDROXY-2-DECENOIC ACID, (E)-10-(10-HDA)(SH)

(E)-10-Hydroxy-2-decenoic acid, 98%, from honey

10-Hydroxy-2-decenoic acid

Royal Jelly acid (Queen Bee Acid)

2-Hydroxy-2-decanoic acid

10-Hydroxy trans-2-decenoic acid

trans-10-Hydroxy-2-decenoic Acid &gt

10H2DA

2-Decenoic acid, 10-hydroxy-, (2E)-

10-Hydroxy-2-decenoic acid USP/EP/BP

10-hydroxydec-2-enoic acid 10-HAD

10-Hydroxy-2-decenoic acidQ: What is 10-Hydroxy-2-decenoic acid Q: What is the CAS Number of 10-Hydroxy-2-decenoic acid Q: What is the storage condition of 10-Hydroxy-2-decenoic acid

Queenbeeaci

(2E)-10-Hydroxy-2-decenoic acid(10-HAD)

HYDROXY-2-DECENOIC ACID, (E)-(10-HDA)

Royal jelly acid / 10-hydroxy-2-decenoic acid

14113-05-4

765-01-5;14113-

14113-05-4.765-01-5

765-01-5;14113-05-4

HOCH2CH26CHCHCOOH

1