10-Hydroxy-2-decenoic acid

Product Name: 10-Hydroxy-2-decenoic acid
CAS No.: 14113-05-4
Chemical Name: 10-Hydroxy-2-decenoic acid
Synonyms: 10-HAD;10-HDA;10H2DA;jelly acid;Queenbeeaci;QUEEN BEE ACID;Queen been acid;ROYAL JELLY ACID;hydroxy-decenouc acid;10-HYDROXYDECENOIC ACID
CBNumber: CB8109967
Molecular Formula: C10H18O3
Formula Weight: 186.25
MOL File: 14113-05-4.mol

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10-Hydroxy-2-decenoic acid Property

Melting point:: 64.0 to 68.0 °C
Boiling point:: 339.2±15.0 °C(Predicted)
Density: 1.038±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 20 mg/ml
form: powder to crystal
pka: 4.78±0.10(Predicted)
color: White to Almost white
LogP: 1.808 (est)
CAS DataBase Reference: 14113-05-4(CAS DataBase Reference)

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Safety

Safety Statements: 24/25
HS Code: 29181990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML3381
Product name: 10-Hydroxy-trans-2-decenoic acid
Purity: ≥98% (HPLC)
Packaging: 10MG
Price: $86.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML3381
Product name: 10-Hydroxy-trans-2-decenoic acid
Purity: ≥98% (HPLC)
Packaging: 50MG
Price: $350
Updated: 2024/03/01

Sigma-Aldrich

Product number: PHL89223
Product name: 10-Hydroxy-trans-2-decenoic acid
Purity: phyproof? Reference Substance
Packaging: 10mg
Price: $608
Updated: 2024/03/01

TCI Chemical

Product number: H1337
Product name: trans-10-Hydroxy-2-decenoic Acid
Purity: >97.0%(GC)(T)
Packaging: 200mg
Price: $72
Updated: 2024/03/01

TCI Chemical

Product number: H1337
Product name: trans-10-Hydroxy-2-decenoic Acid
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $252
Updated: 2024/03/01

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10-Hydroxy-2-decenoic acid Chemical Properties,Usage,Production

Description

10-HDA is an unsaturated fatty acid found in royal jelly produced from the hypopharyngeal and mandibular gland secretions of honeybees. 10-HDA has longevity-promoting effects in C. elegans at a concentration of 25 μM. It down-regulates matrix metalloproteinases (MMPs) in rheumatoid arthritis synovial fibroblasts at a concentration of 1.25 nM and inhibits VEGF-induced angiogenesis in HUVECs at 500 μM. 10-HDA also facilitates differentiation of neurons from neural stem/progenitor cells and promotes collagen production by skin fibroblasts at concentrations of 100 μM and 1.5 mM, respectively.

Uses

10-Hydroxy-2-decenoic acid has antiseptic, anti-inflammatory, anti-obesity, anti-aging, preventing bone loss and anti-tumour pharmacological effects, with potential therapeutic effects for postmenopausal osteoporosis, as well as benefiting the human gastrointestinal tract^[1-3].

Definition

ChEBI: (E)-10-hydroxydec-2-enoic acid is an omega-hydroxy amino acid that is 2-decenoic acid in which one of the hydrogens attached to the terminal carbon is replaced by a hydroxy group and in which the C=C double bond has E configuration. It is a component of royal jelly. It has a role as an animal metabolite and a geroprotector. It is an alpha,beta-unsaturated monocarboxylic acid, a straight-chain fatty acid, a hydroxy monounsaturated fatty acid and an omega-hydroxy-medium-chain fatty acid.

Biological Activity

10-Hydroxy-2-decenoic acid is an orally available royal jelly component that potently inhibits osteoclastogenesis. It binds to free fatty acid receptor 4 (FFAR4) on osteoclasts which inhibits RANKL (receptor activator of nuclear factor-κB (NF-κB) ligand), thereby attenuating the induction of nuclear factor of activated T cells (NFAT) c1. 10-Hydroxy-2-decenoic acid inhibits bone resorption in ovariectomized mice.
The production of pro-inflammatory cytokines, Interleukin (IL)-8, IL-1β and tumor necrosis factor-alpha (TNF-α) in WiDr cells was modulated by 10-HDA. IL-8 were dramatically declined by 10-HDA at 3 mM, while IL-1β and TNF-α were significantly decreased. 10-HDA increased IL-1ra in a dose manner. NF-κB pathway is primarily in response to prototypical pro-inflammatory cytokines, and NF-κB was reduced after 10-HDA treatment. 10-HDA acted as potent bactericide against animal- or human-specific pathogens, including Staphylococcus aureus, Streptococcus alactolyticus, Staphylococcus intermedius B, Staphylococcus xylosus, Salmonella cholearasuis, Vibro parahaemolyticus and Escherichia coli (hemolytic)^[1].

References

[1] YUAN-CHANG YANG. 10-hydroxy-2-decenoic acid of royal jelly exhibits bactericide and anti-inflammatory activity in human colon cancer cells.[J]. BMC Complementary and Alternative Medicine, 2018: 202. DOI:10.1186/s12906-018-2267-9.
[2] YOKO HONDA. 10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling.[J]. Journal of Aging Research, 2015, 2015: 425261. DOI:10.1155/2015/425261.
[3] YOSUKE TSUCHIYA. The key royal jelly component 10-hydroxy-2-decenoic acid protects against bone loss by inhibiting NF-κB signaling downstream of FFAR4.[J]. The Journal of Biological Chemistry, 2020, 295 34: 12224-12232. DOI:10.1074/jbc.RA120.013821.

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View Lastest Price from 10-Hydroxy-2-decenoic acid manufacturers

Hebei Saisier Technology Co., LTD

Product: 10-Hydroxy-2-decenoic acid 14113-05-4
Price: US $6.00/KG
Min. Order: 1KG
Purity: More than 99%
Supply Ability: 2000KG/Month
Release date: 2024-04-12

Hebei Mujin Biotechnology Co.,Ltd

Product: 10-Hydroxy-2-decenoic acid 14113-05-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-09-04

HebeiShuoshengImportandExportco.,Ltd

Product: 10-Hydroxy-2-decenoic acid 14113-05-4
Price: US $6.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 2000KG/Month
Release date: 2024-08-09

14113-05-4, 10-Hydroxy-2-decenoic acid Related Search:

HYDROXY-2-DECENOIC ACID, (E)-10-(10-HDA)(P)

hydroxy-decenouc acid

jelly acid

trans-10-Hydroxy-2-decenoic Acid

(E)-10-hydroxydec-2-enoic acid

Queen been acid

10-HAD,10-hydroxydec-2-enoic acid

OMEGA-HYDROXY C10:1 (2-TRANS)

ROYAL JELLY ACID

QUEEN BEE ACID

(E)-10-HYDROXY-2-DECENOIC ACID

HYDROXY-2-DECENOIC ACID, (E)-10-

10-Hydroxydecylenic acid

ω-Hydroxy-Δ2-decenoic acid

10-HYDROXYDECENOIC ACID

10-HYDROXY-2-(E)-DECENOIC ACID

10-HYDROXY-2TR-DECENOIC ACID

10-HAD

10-HDA

10-HYDROXY-2-DECENOIC ACID (10-HAD)

10-Hydroxy-2tr-Decenoic?Acid?(Royal?Jelly?Acid)?

10-HYDROXY-2-DECENOIC ACID (10HDA)

HYDROXY-2-DECENOIC ACID, (E)-10-(10-HDA)(SH)

(E)-10-Hydroxy-2-decenoic acid, 98%, from honey

10-Hydroxy-2-decenoic acid

Royal Jelly acid (Queen Bee Acid)

2-Hydroxy-2-decanoic acid

10-Hydroxy trans-2-decenoic acid

trans-10-Hydroxy-2-decenoic Acid &gt

10H2DA

2-Decenoic acid, 10-hydroxy-, (2E)-

10-Hydroxy-2-decenoic acid USP/EP/BP

10-hydroxydec-2-enoic acid 10-HAD

10-Hydroxy-2-decenoic acidQ: What is 10-Hydroxy-2-decenoic acid Q: What is the CAS Number of 10-Hydroxy-2-decenoic acid Q: What is the storage condition of 10-Hydroxy-2-decenoic acid

Queenbeeaci

(2E)-10-Hydroxy-2-decenoic acid(10-HAD)

HYDROXY-2-DECENOIC ACID, (E)-(10-HDA)

Royal jelly acid / 10-hydroxy-2-decenoic acid

Hydroxy-2-Decenoic Acid(E)-10-(10-Hda)

Hydroxy-2-Decenoic Acid(E)-10-(P)

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Royal Jelly acid, 10 mM in DMSO

14113-05-4

765-01-5;14113-

14113-05-4.765-01-5

765-01-5;14113-05-4

HOCH2CH26CHCHCOOH

1