Non-steroidal anti-inflammatory analgesic Uses
ChemicalBook > CAS DataBase List > Naproxen sodium

Naproxen sodium

Non-steroidal anti-inflammatory analgesic Uses
Product Name
Naproxen sodium
CAS No.
26159-34-2
Chemical Name
Naproxen sodium
Synonyms
aleve;Naprelan;Anax;(S)-6-METHOXY-ALPHA-METHYL-2-NAPHTHALENEACETIC ACID SODIUM SALT;Anaprox;NAPROXEN SODIUM SALT;Duk-F;Flanax;RS-3650;Aflaxen
CBNumber
CB8114925
Molecular Formula
C14H13O3.Na
Formula Weight
252.24
MOL File
26159-34-2.mol
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Naproxen sodium Property

Melting point:
250-251°C
alpha 
D -11° (in methanol)
storage temp. 
Inert atmosphere,Room Temperature
solubility 
Freely soluble in water, freely soluble or soluble in methanol, sparingly soluble in ethanol (96 per cent).
form 
Solid
color 
White to Off-White
Water Solubility 
Soluble in water up to 100mg/mlSoluble in methanol and chloroform. Slightly soluble in ether. Insoluble in water.
CAS DataBase Reference
26159-34-2(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn,T
Risk Statements 
22-61
Safety Statements 
53-45
RIDADR 
3249
WGK Germany 
3
RTECS 
QJ1047000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2918992090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H360May damage fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M1275
Product name
Naproxen sodium
Purity
98.0-102.0%
Packaging
5g
Price
$92.7
Updated
2024/03/01
Sigma-Aldrich
Product number
1457403
Product name
Naproxen sodium
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Alfa Aesar
Product number
J63103
Product name
Naproxen sodium, 98%
Packaging
5g
Price
$75.5
Updated
2024/03/01
Alfa Aesar
Product number
J63103
Product name
Naproxen sodium, 98%
Packaging
25g
Price
$308
Updated
2024/03/01
Sigma-Aldrich
Product number
N5160
Product name
Naproxen sodium
Purity
meets USP testing specifications
Packaging
5g
Price
$110
Updated
2024/03/01
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Naproxen sodium Chemical Properties,Usage,Production

Non-steroidal anti-inflammatory analgesic

Naproxen sodium is a non-steroidal anti-inflammatory analgesic drug which is more tolerable to human, belonging to the phenylpropionic acid compounds. It plays anti-inflammatory effect by inhibiting prostaglandin synthesis.It is absorbed rapidly after oral administration and the plasma reached the peak concentration within 2 to 4 hours. Food has little effect on the rate of absorption. Naproxen and plasma protein are highly binded(99%); the plasma concentration is between 23~40mcg/ml. The metabolic process is demethylation and then combining with glucuronide; the elimination half-life is 12 to 15 hours, mainly excreted by the urine. Clinical application is to relieve a variety of mild to moderate degree of pain, such as tooth extraction and other postoperative pain, primary dysmenorrhea and headache. It is also used for rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, juvenile arthritis, tendinitis, bursitis and acute gouty arthritis; it also plays a role in arthritis pain, swelling and activity restricted symptom. Psoriatic arthritis and Reiter's syndrome can also be treated with this product. Compared with ibuprofen, fenoprofen, aspirin, sulindac and indomethacin, the symptom relief effect was similar, but the incidence and severity of adverse reactions in the gastrointestinal and neurological systems were low. In addition, this product is also the same as aspirin which can inhibit platelet aggregation and prolong bleeding time; but the effect is reversible, and can be restored after stopping.
Naproxen sodium and plasma protein binding rate is high (99%), and other protein-binding drugs can be replaced by its joint out. Therefore, the acceptance of these drugs (such as oral anticoagulants, sulfonylurea, hydantoins) people should observe the interaction effects. At the same time the application of probenecid, naproxen can increase the plasma concentration, half-life period. Magnesium hydroxide, aluminum can make this product absorption rate slightly lower; sodium bicarbonate can make it higher.

Uses

Used as anti-inflammatory analgesic

Chemical Properties

White Powder

Uses

Naproxen (Aleve, Anaprox) is a COX inhibitor for COX-1 and COX-2 with IC50 of 8.7 μM and 5.2 μM, respectively

Uses

A cyclooxygenase inhibitorNaproxen sodium acts as a nonselective inhibitor of Cox-1 and Cox-2. It serves as an anti-inflammatory agent with analgesic and antipyretic properties. Further, it is used in the treatment of rheumatoid arthritis and other rheumatic or musculoskeletal disorders, dysmenorrhea and acute gout.

Uses

An anti-inflammatory, analgesic, antipyretic. A non-steroidal anti-inflammatory

Definition

ChEBI: The sodium salt of naproxen.

brand name

Aleve (Bayer); Anaprox (Roche);Naprelan (Stat Trade).

General Description

Naproxen sodium (NS) is a sodium salt of propionic acid derivative and demonstrates analgesic, anti-pyretic, and anti-inflammatory properties. It exhibits efficiency in being used as an indomethacin in the treatment of acute musculoskeletal disorders. It belongs to the group of nonsteroidal anti-inflammatory drugs (NSAIDS) and acts by inhibiting the activity of both the cyclooxygenase enzymes, COX-1 & COX-2 and further blocking the synthesis of certain prostaglandins. It is administered in the treatment of ankylosing spondylitis, osteoarthritis, rheumatoid disorders, acute gout, mild to moderate pain, tendonitis, bursitis, dysmenorrhea, fever, and migraine headache. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Biological Activity

Non-selective cyclooxygenase (COX) inhibitor that displays anti-inflammatory, antipyretic and analgesic effects. Has a neuroprotective role against colchicine-induced cognitive impairment and oxidative stress.

Biochem/physiol Actions

Cyclooxygenase (Prostaglandin H synthase 1 and 2) inhibitor.

References

[1]. mendias cl, tatsumi r and allen re. role of cyclooxygenase-1 and -2 in satellite cell proliferation, differentiation, and fusion. muscle nerve, 2004, 30(4):497-500.
[2]. hinz b, cheremina o, besz d, et al. impact of naproxen sodium at over-the-counter doses on cyclooxygenase isoforms in human volunteers. int j clin pharmacol ther, 2008, 46(4):180-6.
[3]. sances g, martignoni e, fioroni l, et al. naproxen sodium in menstrual migraine prophylaxis: a double-blind placebo controlled study. headache, 1990, 30(11):705-9.
[4]. tavolari s, bonafè m, marini m, et al. licofelone, a dual cox/5-lox inhibitor, induces apoptosis in hca-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. carcinogenesis, 2008, 29(2):371-80.

Naproxen sodium Preparation Products And Raw materials

Raw materials

Naproxen

Preparation Products

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Naproxen sodium Suppliers

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View Lastest Price from Naproxen sodium manufacturers

Hebei Weibang Biotechnology Co., Ltd
Product
Naproxen sodium 26159-34-2
Price
US $10.00/KG
Min. Order
100KG
Purity
99%
Supply Ability
100 mt
Release date
2024-11-22
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Naproxen sodium 26159-34-2
Price
US $1.00/KG
Min. Order
1KG
Purity
98.5%~101.5%,USP
Supply Ability
2tons/month
Release date
2021-06-16
Hebei Yanxi Chemical Co., Ltd.
Product
Naproxen Sodium 26159-34-2
Price
US $50.00/Kg/Drum
Min. Order
25KG
Purity
98.5%-101%
Supply Ability
100tons/month
Release date
2020-07-21

26159-34-2, Naproxen sodiumRelated Search:

Sodium benzoate Kresoxim-methyl Methanol Sodium bicarbonate Sodium formate Basic Violet 1 Sodium hydroxide Sodium acetate Acetonitrile Methylparaben Diclofenac sodium Anisole Sodium propionate Naproxen Sodium gluconate (Trifluoromethoxy)benzene p-Anisidine 2-Methoxyethanol

  • 6-methoxy-alpha-methyl-,sodiumsalt,(s)-2-naphthaleneaceticaci
  • 6-methoxy-alpha-methyl-,sodiumsalt,l-(-)-2-naphthaleneaceticaci
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