3-bromo-2,6-difluorobenzoic acid
- Product Name
- 3-bromo-2,6-difluorobenzoic acid
- CAS No.
- 28314-81-0
- Chemical Name
- 3-bromo-2,6-difluorobenzoic acid
- Synonyms
- 2,6-difluoro-3-bromobenzoic acid;3-bromo-2,6-difluorobenzoic acid;Benzoic acid, 3-broMo-2,6-difluoro-;3-Bromo-2,6-difluorobenzoic acid 96%
- CBNumber
- CB81180392
- Molecular Formula
- C7H3BrF2O2
- Formula Weight
- 237
- MOL File
- 28314-81-0.mol
3-bromo-2,6-difluorobenzoic acid Property
- Melting point:
- 137-139℃
- Boiling point:
- 279℃
- Density
- 1.872
- Flash point:
- 123℃
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- color
- White
Safety
- HS Code
- 2916310090
N-Bromosuccinimide Price
- Product number
- B682930
- Product name
- 3-Bromo-2,6-difluorobenzoicAcid
- Packaging
- 5g
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 2621-B-09
- Product name
- 3-Bromo-2,6-difluorobenzoic acid
- Purity
- 96%
- Packaging
- 25g
- Price
- $256
- Updated
- 2021/12/16
- Product number
- X0213
- Product name
- 3-Bromo-2,6-difluorobenzoicacid
- Packaging
- 25g
- Price
- $280
- Updated
- 2021/12/16
- Product number
- HCH0353220
- Product name
- 3-BROMO-2,6-DIFLUOROBENZOIC ACID
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.88
- Updated
- 2021/12/16
- Product number
- PC49617
- Product name
- 3-Bromo-2,6-difluorobenzoicacid
- Purity
- 96%
- Packaging
- 25g
- Price
- $232
- Updated
- 2021/12/16
3-bromo-2,6-difluorobenzoic acid Chemical Properties,Usage,Production
Chemical Properties
Off-white powder
Uses
3-Bromo-2,6-difluorobenzoic Acid is a compound synthesized from an inexpensive starting material 1,3-difluorobenzene.
Synthesis
348-57-2
124-38-9
28314-81-0
(1) Synthesis of 3-bromo-2,6-difluorobenzoic acid: In a dry reaction flask, a hexane solution of 1.6 M n-butyllithium (9.4 mL, 15.0 mmol) was mixed with tetrahydrofuran (20 mL) and cooled to -78 °C. The solution was mixed with tetrahydrofuran (20 mL). To this mixed solution was sequentially added 2,2,6,6-tetramethylpiperidine (2.50 mL, 15.0 mmol) and 1-bromo-2,4-difluorobenzene (2.90 g, 15.0 mmol) and the reaction was stirred for 1 hour at -78 °C. Subsequently, crushed dry ice (5 g) was added to the reaction mixture and stirring was continued at -78 °C for 2 hours. Upon completion of the reaction, the reaction was quenched by the addition of saturated aqueous ammonium chloride solution (5 mL) and the mixture was warmed to room temperature and stirred for 30 minutes. It was diluted by adding water (10 mL) and 1 M hydrochloric acid (30 mL) and extracted with ethyl acetate. The organic phase was washed with water and dried over anhydrous magnesium sulfate. The solvent was removed by concentration under reduced pressure, hexane was added to the residue and the solid product was collected by filtration to afford 3-bromo-2,6-difluorobenzoic acid (2.30 g, 64.6% yield). The product was characterized by 1H-NMR (CDCl3): δ 6.91-6.97 (1H, m), 7.66-7.73 (1H, m).
References
[1] European Journal of Organic Chemistry, 2003, # 23, p. 4618 - 4624
[2] Patent: EP2123644, 2009, A1. Location in patent: Page/Page column 78
[3] Journal of Organic Chemistry, 1990, vol. 55, # 2, p. 773 - 775
[4] Bioorganic and Medicinal Chemistry, 2008, vol. 16, # 23, p. 10001 - 10012
3-bromo-2,6-difluorobenzoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-bromo-2,6-difluorobenzoic acid manufacturers
- Product
- 3-bromo-2,6-difluorobenzoic acid 28314-81-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 5mg
- Purity
- 99%HPLC
- Supply Ability
- 2000tons
- Release date
- 2020-01-07
- Product
- 3-bromo-2,6-difluorobenzoic acid 28314-81-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-25
- Product
- 3-bromo-2,6-difluorobenzoic acid 28314-81-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2019-04-09