ChemicalBook > CAS DataBase List > Palmitoyl Tripeptide-1

Palmitoyl Tripeptide-1

Product Name
Palmitoyl Tripeptide-1
CAS No.
147732-56-7
Chemical Name
Palmitoyl Tripeptide-1
Synonyms
Pal-AHK;L-Lysine, N-(1-oxohexadecyl)glycyl-L-histidyl-;Pal-GHK-OH;Collaxyl II;Palmitoyl-GHK;Pal-GHK, >=95%;Pal-Tripeptide-1;Palm-Gly-His-Lys;Peptides PAL-Ghk;PAL-GLY-HIS-LYS-OH
CBNumber
CB81214020
Molecular Formula
C30H54N6O5
Formula Weight
578.79
MOL File
147732-56-7.mol
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Palmitoyl Tripeptide-1 Property

Boiling point:
913.0±65.0 °C(Predicted)
Density 
1.105
storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 10 mg/ml; Ethanol: 30 mg/ml
form 
A solid
pka
3.16±0.10(Predicted)
Sequence
Pal-Gly-His-Lys
InChIKey
BYUQATUKPXLFLZ-UIOOFZCWSA-N
SMILES
C(O)(=O)[C@H](CCCCN)NC(=O)[C@H](CC1N=CNC=1)NC(=O)CNC(=O)CCCCCCCCCCCCCCC
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
27059
Product name
Pal-GHK
Packaging
100mg
Price
$57
Updated
2024/03/01
Cayman Chemical
Product number
27059
Product name
Pal-GHK
Packaging
250mg
Price
$118
Updated
2024/03/01
Cayman Chemical
Product number
27059
Product name
Pal-GHK
Packaging
500mg
Price
$220
Updated
2024/03/01
Cayman Chemical
Product number
27059
Product name
Pal-GHK
Packaging
1g
Price
$384
Updated
2024/03/01
TRC
Product number
P161025
Product name
PalmitoylTripeptide-1
Packaging
250mg
Price
$100
Updated
2021/12/16
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Palmitoyl Tripeptide-1 Chemical Properties,Usage,Production

Description

A peptide is two or more amino acids joined together and is the building block of protein. Peptides fall into three main categories: signal peptides, carrier peptides, and those that inhibit nerve signals. Signal peptides, like palmitoyl tripeptide-1, act as messengers to cells, which trigger collagen synthesis, which then increases skin firmness.Palmitoyl tripeptide-1 is a small three amino acid signal peptide with the amino sequence of glycine-histidine-lysine (GHK). GHK is attached to palmitic acid (a fatty acid) to increase its skin penetration and oil solubility.

Description

Pal-GHK is a form of the extracellular matrix-derived peptide GHK containing palmitic acid , which allows it to penetrate the stratum corneum to the epidermal and dermal skin layers. Pal-GHK (0.5 μM) increases collagen synthesis in human skin fibroblasts in vitro. It reduces collagen degradation ex vivo in patient-derived human skin samples irradiated with UVA light when used at a concentration of 6 ppm. It has been used with the zwitterionic surfactant C12 dodecyldimethylamine oxide (C12DMAO) to study self-assembly of the mixture into aggregates, ribbons, and nanobelts. Pal-GHK has also been used as an internal standard for the quantification of pal-KTTKS in anti-wrinkle creams by LC-MS/MS.

Uses

Palmitoyl Tripeptide-1, has shown to have effects on on collagen, fibronectin, hyaluronic acid synthesis in human dermal fibroblasts, and thus can be used in preparation of antiaging cosmetic creams.

Application

Palmitoyl Tripeptide-1 (Pal-GHK, SpecPed? PT1P) is useful in anti-aging products and wrinkle treatment products such as gels, serums, lotions and creams. Acting as messengers of cutaneous restructuration and repair, this peptide works synergistically to restore and maintain the skin's youthful appearance.

Clinical Use

Applying palmitoyl tripeptide-1 directly to your skin tells the cells to make more collagen, stimulating new collagen production. It requires at least one month or more to begin to see visible changes from new collagen with maximum results visible after 3 to 4 months. Erin Gilbert, MD, FAAD, Ph.D., and board-certified dermatologist and neuroscientist, continues: "Peptides can be included in serums, moisturizers, and masks," Gilbert explains. "They are also included in some topical serums used after micro-needling or superficial laser procedures to increase the penetration of the peptide and help the skin recover from the procedure."

Safety

The CIR Expert Panel concluded that peptides, such as palmitoyl tripeptide-1, are safe in cosmetics and self-care products. Environmental Working Group (EWG) currently scores palmitoyl tripeptide-1 as “1” or “low hazard.”Overall, peptides, such as palmitoyl tripeptide-1, mimic what already exists in the human body and research on peptides’ impact on the skin shows limited to no skin irritation. In terms of toxicity caused by peptides, there is no published research to document any known toxicity.

Palmitoyl Tripeptide-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Palmitoyl Tripeptide-1 manufacturers

Chongqing Zhihe Biopharmaceutical Co., Ltd.
Product
Pal-Tripeptide-1 147732-56-7
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
≥99%
Supply Ability
20tons
Release date
2024-05-21
Shandong Huizhihan Supply Chain Co., Ltd
Product
Pal-Tripeptide-1 147732-56-7
Price
US $0.00-0.00/box
Min. Order
1box
Purity
99.99%
Supply Ability
1000
Release date
2024-10-30
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Palmitoyl Tripeptide-1 147732-56-7
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10ton
Release date
2024-05-22

147732-56-7, Palmitoyl Tripeptide-1Related Search:


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