Morroniside

Product Name: Morroniside
CAS No.: 25406-64-8
Chemical Name: Morroniside
Synonyms: moloside;Morronisid;Morroniside;b-Morroniside;Morroniside-RM;Morroniside - Bio-X ?;Morroniside Impurity 2;Morroniside, 98%, from Cornus officinalis Sieb. et Zucc.;8-(β-D-Glucopyranosyloxy)-4,4a,8,8a-tetrahydro-3-hydroxy-1-methyl-1H,3H-pyrano[3,4-c]pyran-5-carboxylic acid methyl ester;(1S,3R,4aS,8S,8aS)-8-(beta-D-Glucopyranosyloxy)-4,4a,8,8a-tetrahydro-3-hydroxy-1-methyl-1H,3H-pyrano[3,4-c]pyran-5-carboxylic acid methyl ester
CBNumber: CB81267824
Molecular Formula: C17H26O11
Formula Weight: 406.38
MOL File: 25406-64-8.mol

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Morroniside Property

Melting point:: 133 - 140°C
Boiling point:: 635.6±55.0 °C(Predicted)
Density: 1.52
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
pka: 12.54±0.70(Predicted)
form: Solid
color: White to Off-White
Stability:: Hygroscopic
InChIKey: YTZSBJLNMIQROD-YRYPJNNANA-N
SMILES: [C@@]12([H])[C@H](C)OC(O)C[C@]1([H])C(C(=O)OC)=CO[C@H]2O[C@H]1[C@H](O)[C@H]([C@H](O)[C@@H](CO)O1)O |&1:0,2,8,17,19,20,22,23,25,r|

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Safety

HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: M725700
Product name: Morroniside
Packaging: 10mg
Price: $90
Updated: 2021/12/16

Usbiological

Product number: 300652
Product name: Morroniside
Packaging: 20mg
Price: $349
Updated: 2021/12/16

AK Scientific

Product number: X1190
Product name: Morroniside
Packaging: 10mg
Price: $495
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb594125
Product name: Morroniside
Packaging: 100mg
Price: $552.5
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb105188
Product name: Morroniside
Purity: >98%,Standard References Grade
Packaging: 20mg
Price: $569.5
Updated: 2021/12/16

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Morroniside Chemical Properties,Usage,Production

Chemical Properties

It is derived from the dried mature pulp of Cornus officinalis Sieb. et Zucc., a plant of the Cornaceae family.

Uses

Morroniside is a pharmaceutical agent improving microvascular functional integrity and vascular elements of the neurovascular unit in the treatment of cerebral ischemia.

Definition

ChEBI: Morroniside is a glycoside.

Biological Activity

Morroniside is a bioactive natural product with antioxidant and anti-inflammatory activity. Its activities have included protecttion against cerebral ischemia/reperfusion injury by inhibiting neuron apoptosis and MMP2/9 expression and regulation of hair growth and cycle transition via activation of the Wnt/β-catenin signaling pathway.

in vivo

Morroniside reduces the expression of MMP2 and MMP9 in an I/R injury model. Treatment with Morroniside significantly reduces I/R?associated neuron apoptosis in a dose dependent manner. The results demonstrate that active caspase?3 and Bax are significantly upregulated in the model group compared with the control group, while Bcl?2 is significantly downregulated. The expression of active caspase?3 and Bax is significantly downregulated by Morroniside treatment in a dose?dependent manner, while the expression of Bcl?2 is significantly upregulated^[1]. Morroniside has an ameliorative effect on diabetes-induced alterations such as oxidative stress, inflammation, and apoptosis in the liver of type 2 diabetic db/db mice^[2].

IC 50

MMP2; MMP9

Morroniside Preparation Products And Raw materials

Raw materials

Preparation Products

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Morroniside Suppliers

China 243 India 1 United Kingdom 1 United States 12 Global 257

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

China Langchem Inc.

Tel: 0086-21-58956006
Fax: 0086-21-58956100
Country: China
ProdList: 7811
Advantage: 57

Shenzhen Sungening Bio-Tech Co., Ltd

Tel: +86-0755-89668383
Fax: +86-0755-89594066/4038
Email: sales@sungening.com
Country: China
ProdList: 1319
Advantage: 65

Hangzhou Yuhao Chemical Technology Co., Ltd

Tel: 0571-82693216
Fax: +86-571-82880190
Email: info@yuhaochemical.com
Country: China
ProdList: 6387
Advantage: 52

Dalian Meilun Biotech Co., Ltd.

Tel: 0411-62910999 13889544652
Email: sales@meilune.com
Country: China
ProdList: 4747
Advantage: 58

BioBioPha Co., Ltd.

Tel: 0871-65217109 13211707573;
Fax: 0871-65215563
Email: y.liu@mail.biobiopha.com
Country: China
ProdList: 5653
Advantage: 65

ShangHai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847 13636370518
Fax: 021-55068248
Email: shyysw007@163.com
Country: China
ProdList: 4999
Advantage: 60

Chengdu Ai Keda Chemical Technology Co., Ltd.

Tel: 4008-755-333 18080918076
Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
Advantage: 55

Chengdu Biopurify Phytochemicals Ltd.

Tel: +86-028-82633397 18982077548
Fax: +86-28-82633165
Email: cwb1@biopurify.cn
Country: China
ProdList: 2376
Advantage: 60

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View Lastest Price from Morroniside manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Morroniside 25406-64-8
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-12-04

Zhuozhou Wenxi import and Export Co., Ltd

Product: Morroniside 25406-64-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: Morroniside 25406-64-8
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

25406-64-8, MorronisideRelated Search:

Monobenzone 4-HYDROXYISOLEUCINE epiberberine Coptisine chloride Mangiferin Loganin FRIEDELIN lithospermic acid CIS-HEPTACHLOREPOXIDE EXO-, ISOMER B Tetrahydropyranyl-4-acetic acid (TETRAHYDRO-PYRAN-4-YL)-ACETALDEHYDE METHYL 5,5-DIMETHOXYVALERATE Heterocycles 3,4-DIHYDRO-2-METHOXY-4-METHYL-2H-PYRAN Morroniside BETA-ISOBUTOXYACROLEIN 2-Ethoxy-3,4-dihydro-4-methyl-2H-pyran Tetrahydro

Morroniside

(1S,3R,4aS,8S,8aS)-8-(beta-D-Glucopyranosyloxy)-4,4a,8,8a-tetrahydro-3-hydroxy-1-methyl-1H,3H-pyrano[3,4-c]pyran-5-carboxylic acid methyl ester

8-(β-D-Glucopyranosyloxy)-4,4a,8,8a-tetrahydro-3-hydroxy-1-methyl-1H,3H-pyrano[3,4-c]pyran-5-carboxylic acid methyl ester

Morronisid

methyl 3-hydroxy-1-methyl-8-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-1,3,4,4a,8,8a-hexahydropyrano[3,4-c]pyran-5-carboxylate

Morroniside, 98%, from Cornus officinalis Sieb. et Zucc.

1H,3H-Pyrano[3,4-c]pyran-5-carboxylic acid, 8-(β-D-glucopyranosyloxy)-4,4a,8,8a-tetrahydro-3-hydroxy-1-methyl-, methyl ester, (1S,3R,4aS,8S,8aS)-

1H,3H-Pyrano[3,4-c]pyran-5-carboxylicacid, 8-(b-D-glucopyranosyloxy)-4,4a,8,8a-tetrahydro-3-hydroxy-1-methyl-,methyl ester, (1S,3R,4aS,8S,8aS)-

Methyl (1S,3R,4aS,8S,8aS)-3-hydroxy-1-methyl-8-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-4,4a,8,8a-tetrahydro-1H,3H-pyrano[3,4-c]pyran-5-carboxylate

b-Morroniside

moloside

Morroniside-RM

Morroniside Impurity 2

Morroniside - Bio-X ?

25406-64-8

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract