ChemicalBook > CAS DataBase List > 2,6-Dichloro-3-nitropyridine

2,6-Dichloro-3-nitropyridine

Product Name
2,6-Dichloro-3-nitropyridine
CAS No.
16013-85-7
Chemical Name
2,6-Dichloro-3-nitropyridine
Synonyms
PYRIDINE, 2,6-DICHLORO-3-NITRO-;26DC3NP;TIMTEC-BB SBB003614;2,6-Dichloro-3-nitro;Flupirtine Impurity H;DICHLORONITROPYRIDINE;Dichloro-3-nitropyrid;6-Dichloro-3-nitropyridine;2,6-DICHLORO-3-NITROPYRIDINE;2,6-Dichloro-3-nitropyrid...
CBNumber
CB8130660
Molecular Formula
C5H2Cl2N2O2
Formula Weight
192.99
MOL File
16013-85-7.mol
More
Less

2,6-Dichloro-3-nitropyridine Property

Melting point:
55-60 °C(lit.)
Boiling point:
295.5±35.0 °C(Predicted)
Density 
1.6791 (rough estimate)
refractive index 
1.6100 (estimate)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
soluble in Methanol
form 
Liquid
pka
-5.76±0.10(Predicted)
color 
Clear colorless to light yellow
BRN 
1619741
InChI
InChI=1S/C5H2Cl2N2O2/c6-4-2-1-3(9(10)11)5(7)8-4/h1-2H
InChIKey
SHCWQWRTKPNTEM-UHFFFAOYSA-N
SMILES
C1(Cl)=NC(Cl)=CC=C1[N+]([O-])=O
CAS DataBase Reference
16013-85-7(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
36/37/38-42/43-43
Safety Statements 
22-26-36/37-37/39-24-36/37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29333990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
193585
Product name
2,6-Dichloro-3-nitropyridine
Purity
technical grade, 92%
Packaging
10g
Price
$40
Updated
2023/01/07
TCI Chemical
Product number
D2761
Product name
2,6-Dichloro-3-nitropyridine
Purity
>98.0%(GC)
Packaging
5g
Price
$30
Updated
2025/07/31
TCI Chemical
Product number
D2761
Product name
2,6-Dichloro-3-nitropyridine
Purity
>98.0%(GC)
Packaging
25g
Price
$89
Updated
2025/07/31
Usbiological
Product number
160001
Product name
2,6-Dichloro-3-nitropyridine
Packaging
25g
Price
$403
Updated
2021/12/16
TRC
Product number
D435515
Product name
2,6-Dichloro-3-nitropyridine
Packaging
100g
Price
$415
Updated
2021/12/16
More
Less

2,6-Dichloro-3-nitropyridine Chemical Properties,Usage,Production

Chemical Properties

yellow crystalline powder or chunks

Uses

2,6-Dichloro-3-nitropyridine was used:

  • in the synthesis of pyridyldifluoroacetates
  • as starting reagent in the preparation of bicyclooxacalixhetarene

Definition

Nitropyridine nucleus played a pivotal role in the development of different medicinal agents and in the field of agrochemicals. It is seen from the current literature that pyridine derivatives have been developed and used as insecticidal agents. Nitrated pyridines and their derivatives are important intermediates in synthesis of heterocyclic compounds in dyes and pharmaceutical products. Fused heterocycles containing nitropyridine systems have been associated with several biological and medicinal activities including antiolytic, antiviral and anti-inflammatory profiles.

General Description

2,6-Dichloro-3-nitropyridine undergoes macrocyclic condensation reaction with resorcinol derivatives to yield chiral tetraoxacalix[2]arene[2]pyridines.

Synthesis

2402-78-0

16013-85-7

General procedure for the synthesis of 2,6-dichloro-3-nitropyridine from 2,6-dichloropyridine: 80 mL of concentrated sulfuric acid was added to a 150 mL three-necked flask with stirring at room temperature, and 7.4 g (0.05 mol) of 2,6-dichloropyridine (IV) was slowly added, followed by the slow addition of 10.1 g (0.1 mol) of potassium nitrate. After the addition was completed, stirring was continued for 30 minutes, then the temperature was slowly increased to 120°C and the reaction was maintained at this temperature for 10 hours. Upon completion of the reaction, the reaction mixture was cooled to room temperature and poured into crushed ice with stirring. The precipitated white solid precipitate was washed to neutrality with ice water, immediately subjected to diafiltration, and dried to give 7.75 g of white solid 2,6-dichloro-3-nitropyridine (V) in 80% yield and melting point of 61-63 °C.

Structure and conformation

The asymmetric unit of 2,6-Dichloro-3-nitropyridine consists of two crystallographically independent mol-ecules. The pyridine ring in each mol-ecule is essentially planar, with maximum deviations of 0.004 (4) and 0.007 (4)Å. Short Cl-O [3.09?(3) and 3.13 (4)Å] and Cl-Cl [3.38 (12)Å] contacts were observed. No significant inter-molecular inter-actions were observed in the crystal packing.

References

[1] Patent: CN103936766, 2016, B. Location in patent: Paragraph 0032-0033
[2] Patent: US2006/80790, 2006, A1. Location in patent: Page/Page column 2
[3] Patent: WO2017/31176, 2017, A1. Location in patent: Page/Page column 33-34
[4] Journal of Heterocyclic Chemistry, 1984, vol. 21, # 5, p. 1521 - 1525
[5] ChemMedChem, 2015, vol. 10, # 2, p. 368 - 379

2,6-Dichloro-3-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2,6-Dichloro-3-nitropyridine Suppliers

Americas 1 Belgium 3 China 428 Europe 4 France 1 Germany 7 India 62 Japan 4 Jordan 1 Slovakia 1 South Korea 1 Switzerland 3 The Netherlands 2 Ukraine 1 United Kingdom 25 United States 59 Global 603
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
Advantage
60
AbaChemScene
Tel
732-484-9848
Fax
888-484-5008
Email
sales@chemscene.com
Country
United States
ProdList
3982
Advantage
60
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Protheragen-ING
Tel
+16313385890
Email
info@protheragen-ing.com
Country
United States
ProdList
3868
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Synthonix Inc
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
6872
Advantage
58
Chemlex Pharmaceuticals LLC
Tel
--
Fax
--
Email
chemlexpharma@yahoo.com
Country
United States
ProdList
238
Advantage
0
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
General Synco, Inc
Tel
--
Fax
--
Email
support@generalsynco.com
Country
United States
ProdList
65
Advantage
58
Tyger Scientific Inc.
Tel
--
Fax
--
Email
sales@tygersci.com
Country
United States
ProdList
402
Advantage
58
Wilshire Technologies, Inc.
Tel
--
Fax
--
Email
info@wilshiretechnologies.com
Country
United States
ProdList
893
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
Chemphtec Corporation
Tel
--
Fax
--
Email
fo@chemphtec.com
Country
United States
ProdList
2181
Advantage
58
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
VWR International, LLC.
Tel
--
Fax
--
Email
@sargentwelch.com
Country
United States
ProdList
6262
Advantage
58
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
QV Chemicals LLC
Tel
--
Fax
--
Email
info@qvchemicals.com
Country
United States
ProdList
257
Advantage
50
Chiral Management
Tel
--
Fax
--
Email
sales@chiralmanagement.com
Country
United States
ProdList
1332
Advantage
30
BroadPharm. Inc.
Tel
--
Fax
--
Email
sales@broadpharm.com
Country
United States
ProdList
891
Advantage
50
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Synthonix
Tel
--
Fax
--
Email
info@synthonix.com
Country
United States
ProdList
1423
Advantage
68
HBCChem, Inc.
Tel
--
Fax
--
Email
Sales@hbcchem-inc.com
Country
United States
ProdList
887
Advantage
50
Small Molecules, Inc.
Tel
--
Fax
--
Email
sales@small-molecules.com
Country
United States
ProdList
990
Advantage
50
HBCChem Inc.
Tel
--
Fax
--
Email
sales@hbcchem-inc.com
Country
United States
ProdList
4569
Advantage
30
HDH Pharma, Inc.
Tel
--
Fax
--
Email
catalog@hdhpharma.com
Country
United States
ProdList
6248
Advantage
62
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
Magical Scientific LLC
Tel
--
Fax
--
Country
United States
ProdList
703
Advantage
0
ChemService Inc.
Tel
--
Fax
--
Country
United States
ProdList
6379
Advantage
68
AstaTech, Inc
Tel
--
Fax
--
Email
sales@astatechinc.com
Country
United States
ProdList
6371
Advantage
58
Ryan Scientific, Inc.
Tel
--
Fax
--
Email
ryan.reichlyn@ryansci.com
Country
United States
ProdList
6439
Advantage
60
CHEM-IS-TRY, Inc.
Tel
--
Fax
--
Email
sales@chem-is-try.com
Country
United States
ProdList
551
Advantage
56
Ivy Fine Chemicals
Tel
--
Fax
--
Email
sales@ivychem.com
Country
United States
ProdList
6493
Advantage
58
Beta Pharma, Inc.
Tel
--
Fax
--
Email
sales@betapharma.com
Country
United States
ProdList
6226
Advantage
60
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
NOVASYN ORGANICS PVT LTD
Tel
--
Fax
--
Email
info@novasynorganics.com
Country
United States
ProdList
1316
Advantage
55
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
Aagile Labs Division of Tyger Scientific
Tel
--
Fax
--
Email
tygersci@yahoo.com
Country
United States
ProdList
6568
Advantage
68
Wilshire Chemical Company Inc.
Tel
--
Fax
--
Email
WilshrChem@AOL.COM
Country
United States
ProdList
3498
Advantage
58
Acros Organics USA
Tel
--
Fax
--
Email
eveleth@fisherchem.com
Country
United States
ProdList
3846
Advantage
81
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
More
Less

View Lastest Price from 2,6-Dichloro-3-nitropyridine manufacturers

Zhengzhou Lingzhiyue Technology Co., Ltd
Product
2,6-Dichloro-3-nitropyridine 16013-85-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
15
Release date
2023-10-28
Henan Aochuang Chemical Co.,Ltd.
Product
2,6-Dichloro-3-nitropyridine 16013-85-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-17
TAIZHOU DKD CHEMICAL CO., LTD.
Product
2,6-Dichloro-3-nitropyridine 16013-85-7
Price
US $0.00/kg
Min. Order
25kg
Purity
99%
Supply Ability
20 tons
Release date
2022-11-08

16013-85-7, 2,6-Dichloro-3-nitropyridineRelated Search:

Thionyl chloride 4-Chloro-3-nitropyridine 3-Aminopyridine 3-Nitropyridine 2,6-Dichloropyridine 2-Chloro-3-nitropyridine Dichloroethane Dichloroacetic acid 4,6-Dichloropyrimidine Clopyralid 2-Chloro-5-chloromethylpyridine Flupirtine Maleate IMpurity C Flupirtine DiMer Flupirtine Maleate IMpurity D 5-[[(4-Fluorophenyl)Methyl]aMino]-1,3-dihydro-2H-iMidazo[4,5-b]pyridin-2-one WBAZQELGBFQHPE-HGSONKNXSA-N Flupirtine-N2-β-D-Glucuronide Flupirtine-N6-β-D-Glucuronide

  • 2,6-DICHLORO-3-NITROPYRIDINE
  • TIMTEC-BB SBB003614
  • 2,6-DICHLORO-3-NITROPYRIDINE, TECH., 92%
  • DICHLORONITROPYRIDINE
  • 2,6-Dichloro-3-nitro
  • 2,6-DICHLORO-3-NITROPYRIDINE 98+%
  • Flupirtine Impurity H
  • 2,6-Dichloro-3-nitropyridine ,92%
  • 2,6-Dichloro-3-nitropyridine,90%,tech.
  • 2,6-Dichloro-3-nitropyrid...
  • 2,6-Dichloro-3-nitropyridine, tech., 90% 50GR
  • 6-Dichloro-3-nitropyridine
  • Dichloro-3-nitropyrid
  • 2,6-Dichloro-3-nitropyridine technical grade, 92%
  • FlupirtinemaleateintermediateⅢ
  • PYRIDINE, 2,6-DICHLORO-3-NITRO-
  • 3-NITRO-2,6-DICHLOROPYRIDINE
  • 2,6-Dichloro-3-nitropyridine &gt
  • 2,6-dichloro-3-nito pyridine
  • 2,6-Dichloro-3-nitropyridine ISO 9001：2015 REACH
  • 26DC3NP
  • 16013-85-7
  • 14014-85-7
  • 6013-85-7
  • C5H2N2O2Cl2
  • C5H2ClN2O2
  • C5H2CI2N2O2
  • C5H5Cl2N2O2
  • Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyridines
  • Chloropyridines
  • Halopyridines
  • Building Blocks
  • C5
  • Chemical Synthesis
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Chloropyridines
  • Halopyridines
  • C5Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Pyridine series
  • Pyridines derivates
  • Pyridine
  • pyridine derivative
  • Heterocycles
  • Pyridines
  • bc0001