ChemicalBook > CAS DataBase List > 2-Methyl-3-amino-4-acetylanisole

2-Methyl-3-amino-4-acetylanisole

Product Name: 2-Methyl-3-amino-4-acetylanisole
CAS No.: 912347-94-5
Chemical Name: 2-Methyl-3-amino-4-acetylanisole
Synonyms: 2-methyl-3-amino-4-acetylanisole;6-ACETYL-3-METHOXY-2-METHYL ANILINE;1-(2-aMino-4-Methoxy-3-Methylphenyl)-;2-AMino-4-Methoxy-3-Methylacetophenone;2-Amino-4-methoxy-3-methylbenzoic acid;(2-Amino-3-methyl-4-methoxyphenyl)acetone;2'-Amino-3'-methyl-4'-methoxyacetophenone;2-Methyl-3-amino-4-acetylanisole USP/EP/BP;1-(2-Amino-4-methoxy-3-methylphenyl)ethanone;1-(2-aMino-4-Methoxy-3-Methylphenyl)ethan-1-one
CBNumber: CB81465767
Molecular Formula: C10H13NO2
Formula Weight: 179.22
MOL File: 912347-94-5.mol

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2-Methyl-3-amino-4-acetylanisole Property

Melting point:: 107 °C
Boiling point:: 336.0±37.0 °C(Predicted)
Density: 1.096±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
form: powder to crystal
pka: 1.74±0.10(Predicted)
color: White to Yellow to Orange
InChI: InChI=1S/C10H13NO2/c1-6-9(13-3)5-4-8(7(2)12)10(6)11/h4-5H,11H2,1-3H3
InChIKey: VXBGCEDOGYNWHE-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC=C(OC)C(C)=C1N)C

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Safety

HS Code: 2922500090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: A3027
Product name: 2'-Amino-3'-methyl-4'-methoxyacetophenone
Purity: >97.0%(GC)(T)
Packaging: 1g
Price: $90
Updated: 2025/07/31

TCI Chemical

Product number: A3027
Product name: 2'-Amino-3'-methyl-4'-methoxyacetophenone
Purity: >97.0%(GC)(T)
Packaging: 5g
Price: $312
Updated: 2025/07/31

TRC

Product number: A613115
Product name: 1-(2-Amino-4-methoxy-3-methylphenyl)ethanone
Packaging: 500mg
Price: $115
Updated: 2021/12/16

TRC

Product number: A613115
Product name: 1-(2-Amino-4-methoxy-3-methylphenyl)ethanone
Packaging: 1g
Price: $160
Updated: 2021/12/16

Apolloscientific

Product number: OR301383
Product name: 1-(2-Amino-4-methoxy-3-methylphenyl)ethanone
Purity: 97%
Packaging: 1g
Price: $70
Updated: 2021/12/16

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2-Methyl-3-amino-4-acetylanisole Chemical Properties,Usage,Production

Synthesis

75-05-8

19500-02-8

912347-94-5

To a solution of 2-methyl-3-methoxyaniline (5.0 g, 36.5 mmol) in p-xylene (80 mL) was cooled to 0 °C, and a dichloromethane solution (36.5 mL) of 1 M BCl3 was slowly added. The reaction mixture was stirred at 0 °C for 30 min under nitrogen protection. Subsequently, acetonitrile (2.6 mL, 54.7 mmol) was added and stirring was continued at 0 °C for 30 min. In another reaction flask, AlCl3 (4.87 g, 36.5 mmol) was suspended in anhydrous dichloromethane (50 mL), cooled to 0 °C, and the aforementioned p-xylene solution was added dropwise through the addition funnel under nitrogen protection. After addition, the dichloromethane was removed under vacuum after stirring at 0°C for 45 minutes. The remaining p-xylene solution was heated to 70°C and maintained for 18 hours, followed by cooling to room temperature. Water (80 mL) was added and again heated to 70°C maintained for 1 hour and cooled to room temperature. The reaction mixture was diluted with ethyl acetate and the aqueous layer was separated. The organic layer was washed sequentially with equal volumes of water and saturated saline, dried over anhydrous MgSO4 and concentrated under reduced pressure. 1H), 7.03 (br.s., 2H), 7.65 (d, J = 9.04 Hz, 1H). LC-MS (ESI): m/z 180.10 (M + H)+.

References

[1] Patent: US2010/196321, 2010, A1. Location in patent: Page/Page column 20
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 7, p. 3021 - 3026
[3] Patent: WO2008/96002, 2008, A1. Location in patent: Page/Page column 82-83
[4] Patent: WO2008/92954, 2008, A2. Location in patent: Page/Page column 28-29
[5] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 17, p. 4853 - 4858

2-Methyl-3-amino-4-acetylanisole Preparation Products And Raw materials

Raw materials

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View Lastest Price from 2-Methyl-3-amino-4-acetylanisole manufacturers

Career Henan Chemical Co

Product: 2-Methyl-3-amino-4-acetylanisole 912347-94-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1000KG
Release date: 2019-09-04

912347-94-5, 2-Methyl-3-amino-4-acetylanisoleRelated Search:

Methanol Kresoxim-methyl 4-Acetylbenzoic acid Paraquat dichloride Methylparaben Basic Violet 1 4-Methylanisole ALTRENOGEST Lithium bis(trimethylsilyl)amide Acetonitrile N,N-Dimethyl-1,4-phenylenediamine 2-Methyl-3-nitroanisole 2-Methoxyethanol L-PICEIN DIMETHYLAMINOPYRIDINE, POLYMER-BOUND Methyl acetate Tris(hydroxymethyl)aminomethane Methyl acrylate

1-(2-Amino-4-methoxy-3-methylphenyl)ethanone 97%

Ethanone, 1-(2-amino-4-methoxy-3-methylphenyl)-

2-methyl-3-amino-4-acetylanisole

1-(2-Amino-4-methoxy-3-methylphenyl)ethanone

6-ACETYL-3-METHOXY-2-METHYL ANILINE

2-Amino-4-methoxy-3-methylbenzoic acid

1-(2-aMino-4-Methoxy-3-Methylphenyl)-

1-(2-aMino-4-Methoxy-3-Methylphenyl)ethan-1-one

2'-Amino-3'-methyl-4'-methoxyacetophenone

2-AMino-4-Methoxy-3-Methylacetophenone

(2-Amino-3-methyl-4-methoxyphenyl)acetone

2-Methyl-3-amino-4-acetylanisole USP/EP/BP

912347-94-5

Amino Acid Derivatives

Drug Intermediates

Multisubstituted Benzene