5-Fluoro-2-nitropyridine

Product Name: 5-Fluoro-2-nitropyridine
CAS No.: 779345-37-8
Chemical Name: 5-Fluoro-2-nitropyridine
Synonyms: Pyridine, 5-fluoro-2-nitro-;5-Fluoro-2-nitropyridine ISO 9001：2015 REACH
CBNumber: CB81471287
Molecular Formula: C5H3FN2O2
Formula Weight: 142.09
MOL File: 779345-37-8.mol

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5-Fluoro-2-nitropyridine Property

Boiling point:: 245.0±20.0 °C(Predicted)
Density: 1.439±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
pka: -5.01±0.22(Predicted)
form: solid
color: Light yellow to yellow
InChI: InChI=1S/C5H3FN2O2/c6-4-1-2-5(7-3-4)8(9)10/h1-3H
InChIKey: CGFYNRVHPARGFY-UHFFFAOYSA-N
SMILES: C1([N+]([O-])=O)=NC=C(F)C=C1

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Safety

Hazard Codes: Xn
Risk Statements: 22
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: F597690
Product name: 5-Fluoro-2-nitropyridine
Packaging: 25mg
Price: $45
Updated: 2021/12/16

TRC

Product number: F597690
Product name: 5-Fluoro-2-nitropyridine
Packaging: 250mg
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: PC445034
Product name: 5-Fluoro-2-nitropyridine
Packaging: 250mg
Price: $44
Updated: 2021/12/16

ChemScene

Product number: CS-D0783
Product name: 5-Fluoro-2-nitropyridine
Purity: 99.61%
Packaging: 1g
Price: $76
Updated: 2021/12/16

Apolloscientific

Product number: PC445034
Product name: 5-Fluoro-2-nitropyridine
Packaging: 1g
Price: $87
Updated: 2021/12/16

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5-Fluoro-2-nitropyridine Chemical Properties,Usage,Production

Uses

5-Fluoro-2-nitropyridine is mainly used as a pharmaceutical intermediate. It can be used to prepare substituted heterocyclic compounds with cell proliferation inhibitory activity.

Synthesis

21717-96-4

779345-37-8

General procedure for the synthesis of 5-fluoro-2-nitropyridine from 2-amino-5-fluoropyridine: 2-amino-5-fluoropyridine (6.0 g, 53.51 mmol, 1.0 eq.) was dissolved in concentrated H2SO4 (60 ml) and cooled to 0 °C (solution A). In another flask, hydrogen peroxide (13 ml) was slowly added to concentrated sulfuric acid at 0°C (Solution B). Solution A was added dropwise to solution B at 0°C. The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the mixture was poured into ice-cold water and the product was extracted with EtOAc. The organic layers were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give pure 5-fluoro-2-nitropyridine (3.0 g, 39.45% yield). Mass spectrum (electrospray ionization): m/z 142.09 [M + H]+.

References

[1] Patent: US2004/209886, 2004, A1
[2] Journal of Medicinal Chemistry, 2007, vol. 50, # 15, p. 3627 - 3644
[3] Patent: WO2015/131080, 2015, A1. Location in patent: Paragraph 001083; 001084
[4] Patent: US2010/160340, 2010, A1. Location in patent: Page/Page column 7
[5] Patent: WO2012/97682, 2012, A1. Location in patent: Page/Page column 158

5-Fluoro-2-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Fluoro-2-nitropyridine Suppliers

China 122 Germany 1 India 2 United Kingdom 2 United States 14 Global 141

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Pure Chemistry Scientific Inc.

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View Lastest Price from 5-Fluoro-2-nitropyridine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 5-Fluoro-2-nitropyridine 779345-37-8
Price: US $1.00-1.00/Kg/Drum
Min. Order: 1g
Purity: 98%
Supply Ability: 50tons
Release date: 2020-05-12

Dideu Industries Group Limited

Product: 5-Fluoro-2-nitropyridine 779345-37-8
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons min
Release date: 2021-09-22

Career Henan Chemical Co

Product: 5-Fluoro-2-nitropyridine 779345-37-8
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 10000KGS
Release date: 2020-01-10

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5-Fluoro-2-nitropyridine ISO 9001：2015 REACH

779345-37-8

Fluorine series