ChemicalBook > CAS DataBase List > Danusertib

Danusertib

Product Name
Danusertib
CAS No.
827318-97-8
Chemical Name
Danusertib
Synonyms
CS-1856;CS-1969;PHA-739358;danusertib;Unii-m3X659D0fy;Danusertib USP/EP/BP;Danusertib(PHA-739358);PHA-739358(Danusertib);PHA-739358 Danusertib PHA739358;PHA-739358; PHA739358; PHA 739358
CBNumber
CB81518500
Molecular Formula
C26H30N6O3
Formula Weight
474.55
MOL File
827318-97-8.mol
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Danusertib Property

Melting point:
>145°C (dec.)
Boiling point:
664.1±55.0 °C(Predicted)
Density 
1.322
storage temp. 
Refrigerator
solubility 
DMSO (Slightly), Methanol (Slightly)
form 
Solid
pka
13.70±0.20(Predicted)
color 
Pale Beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
18387
Product name
Danusertib
Purity
≥95%
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
18387
Product name
Danusertib
Purity
≥95%
Packaging
5mg
Price
$193
Updated
2024/03/01
Cayman Chemical
Product number
18387
Product name
Danusertib
Purity
≥95%
Packaging
10mg
Price
$341
Updated
2024/03/01
Cayman Chemical
Product number
18387
Product name
Danusertib
Purity
≥95%
Packaging
50mg
Price
$1148
Updated
2024/03/01
Usbiological
Product number
474091
Product name
Danusertib
Packaging
100mg
Price
$1932
Updated
2021/12/16
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Danusertib Chemical Properties,Usage,Production

Uses

An Aurora kinase inhibitor, used to treat patients with chromic myeloid leukemia. It is a COVID19-related research product.

Uses

Danusertib is an Aurora kinase inhibitor, used to treat patients with chromic myeloid leukemia.

Definition

ChEBI: N-[5-[(2R)-2-methoxy-1-oxo-2-phenylethyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methyl-1-piperazinyl)benzamide is a member of piperazines.

Biological Activity

danusertib (previously known as pha-739358), a 3-aminopyrazole derivative identified during the development of the pyrrolopyrazole sub-series, is a potent small-molecule inhibitor of aurora kinases family members with a dominant inhibition for aurora b kinase (abk). this pan-aurora kinases inhibitor is also able to inhibit several tyrosine kinases, including t315i mutant, ret, trk-a and fibroblast growth factor receptor-1 (fgfr-1), which are involved in multiple malignancies, such as chronic myelogenous leukemia (cml), acute lymphoblastic leukemia (all), thyroid prostate and breast carcinoma. thus, in many previous studies, danusertib exhibits remarkable antitumor activity in a number of different xengorafts, spontaneous, and transgenic animal tumor models with a favorable pharmacokinetic and safety profile.carpinelli p, ceruti r, giorgini ml, cappella p, gianellini l, croci v, degrassi a, texido g, rocchetti m, vianello p, rusconi l, storici p, zugnoni p, arrigoni c, soncini c, alli c, patton v, marsiglio a, ballinari d, pesenti e, fancelli d, moll j. pha-739358, a potent inhibitor of aurora kinases with a selecyive target inhibiton profile relevant to cancer. mol cancer ther 2007; 6(12 pt 1): 3158-3168

target

Aurora A/B/C

Danusertib Preparation Products And Raw materials

Raw materials

Preparation Products

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827318-97-8, DanusertibRelated Search:

N-ACETYL-L-TYROSINE ETHYL ESTER Anisole Pralmorelin 2-Methoxyethanol (Trifluoromethoxy)benzene 4-Methoxyphenylacetone p-Anisaldehyde 4-Methoxybenzylchloride 4'-Methoxyacetophenone p-Anisidine Pyrrolidine PHA-793887 Tadalafil Dasatinib Danusertib Methoxy

  • PHA-739358
  • (R)-N-(5-(2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide,PHA739358
  • Benzamide, 4-(4-methyl-1-piperazinyl)-N-(1,4,5,6-tetrahydro-5-((2R)- methoxyphenylacetyl)pyrrolo(3,4-C)pyrazol-3-yl)-
  • Unii-m3X659D0fy
  • Danusertib(PHA-739358)
  • danusertib
  • N-[5-((2R)-2-Methoxy-2-phenylethanoyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide
  • PHA-739358(Danusertib)
  • 4-(4-Methyl-1-piperazinyl)-N-[1,4,5,6-tetrahydro-5-[(2R)-2-Methoxy-2-phenylacetyl]pyrrolo[3,4-c]pyrazol-3-yl]benzaMide
  • N-{5-[(2R)-2-Methoxy-2-phenylacetyl]-1H,4H,5H,6H-pyrrolo[3,4-c]pyrazol-3-yl}-4-(4-Methylpiperazin-1-yl)benzaMide
  • (R)-N-(5-(2-Methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-(4-Methylpiperazin-1-yl)benz
  • (R)-N-(5-(2-methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl)-4-(4-methylpiperazin-1-yl)benzamide
  • Danusertib N-[5-((2R)-2-Methoxy-2-phenylethanoyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide
  • PHA-739358; PHA739358; PHA 739358
  • (R)-N-(5-(2-Methoxy-2-phenylacetyl)-1,4,5,6-tetrahydropyrrolo-[3,4-c]pyrazol-3-yl)-4-(4-methyl
  • N-[5-((2R)-2-Methoxy-2-phenylethanoyl)-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide Danusertib (PHA-739358)
  • CS-1856
  • CS-1969
  • Benzamide, 4-(4-methyl-1-piperazinyl)-N-[1,4,5,6-tetrahydro-5-[(2R)-2-methoxy-2-phenylacetyl]pyrrolo[3,4-c]pyrazol-3-yl]-
  • Danusertib USP/EP/BP
  • N-[5-[(2R)-2-methoxy-2-phenylacetyl]-4,6-dihydro-1H-pyrrolo[3,4-c]pyrazol-3-yl]-4-(4-methylpiperazin-1-yl)benzamide
  • PHA-739358 Danusertib PHA739358
  • 827318-97-8
  • C26H30N6O
  • Inhibitor
  • Apis
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals