ChemicalBook > CAS DataBase List > Acrichin dihydrochloride

Acrichin dihydrochloride

Product Name
Acrichin dihydrochloride
CAS No.
69-44-3
Chemical Name
Acrichin dihydrochloride
Synonyms
AMODIAQUINE HCL;camoquinhydrochloride;Amodiaquine HCL USP31;AMODIAQUIN HYDROCHLORIDE;Acrichin dihydrochloride;Amodiquine hydrochloride;AMODIAQUINE HYDROCHLORIDE;AMODIAQUIN DIHYDROCHLORIDE;AMODIAQUINE DIHYDROCHLORIDE;BULK DRUG : AMODIAQUINE HYDROCHLORIDE (DMF GRADE)
CBNumber
CB8156037
Molecular Formula
C20H23Cl2N3O
Formula Weight
392.32
MOL File
69-44-3.mol
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Acrichin dihydrochloride Property

storage temp. 
Sealed in dry,Room Temperature
solubility 
DMSO: 125 mg/mL (291.52 mM)
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
C429303
Product name
4-((7-Chloroquinolin-4-yl)amino)-2-((diethylamino)methyl)phenolDihydrochloride
Packaging
10mg
Price
$45
Updated
2021/12/16
ApexBio Technology
Product number
C7157
Product name
Amodiaquine hydrochloride
Packaging
100mg
Price
$50
Updated
2021/12/16
ChemScene
Product number
CS-0013341
Product name
Amodiaquine(dihydrochloride)
Purity
≥98.0%
Packaging
100mg
Price
$50
Updated
2021/12/16
Matrix Scientific
Product number
099311
Product name
4-((7-Chloroquinolin-4-yl)amino)-2-((diethylamino)-methyl)phenol dihydrochloride
Purity
95+%
Packaging
10g
Price
$10
Updated
2021/12/16
ApexBio Technology
Product number
C7157
Product name
Amodiaquine hydrochloride
Packaging
200mg
Price
$80
Updated
2021/12/16
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Acrichin dihydrochloride Chemical Properties,Usage,Production

Chemical Properties

Yellow crystalline solid; odorless; bitter. Soluble in water; sparingly soluble in alcohol; very slightly soluble in benzene, chloroform, and ether.

Originator

Camoquin HCl,Parke Davis,US,1950

Uses

Medicine (antimalarial).

Manufacturing Process

72.8 g (0.5 mol) of p-aminophenol hydrochloride is dissolved in 500 cc of water and added to 99 g (0.5 mol) of 4,7-dichloroquinoline. After a few minutes of warming in a steam bath, 4-(4'-hydroxyanilino)-7-chloroquinoline hydrochloride, of sufficient purity for use in further experiments, precipitates as a yellow crystalline solid. Recrystallized from methanol, the MP is over 300°C.
A mixture consisting of 13.5 g of 4-(4'-hydroxyanilino)-7-chloroquinoline hydrochloride dissolved in absolute ethanol is treated with a solution of 4.38 g of diethylamine and 1.8 g of paraformaldehyde in 20 cc of absolute ethanol. The reaction mixture is heated under reflux for 16 hours, evaporated to onehalf volume and the warm solution treated with an excess of hydrogen chloride dissolved in absolute ethanol. Acetone is added to the warm solution until it becomes turbid and then the solution is cooled. The crude dihydrochloride which separates is collected and purified by recrystallization from methanol; MP 240-242°C.
By using an equivalent amount of 4-(4'-hydroxyanilino)-7-bromoquinoline in the above procedure, 4-(3'-diethylaminomethyl-4'-hydroxyanilino)-7- bromoquinoline dihydrochloride is obtained; MP (base) 206-208°C dec.

brand name

Camoquin (Parke-Davis).

Therapeutic Function

Antimalarial

Acrichin dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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Acrichin dihydrochloride Suppliers

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View Lastest Price from Acrichin dihydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Acrichin dihydrochloride 69-44-3
Price
US $0.00/Kg/Drum
Min. Order
25KG
Purity
97%-103%; USP
Supply Ability
500kg
Release date
2021-08-20
Anhui Ruihan Technology Co., Ltd
Product
Acrichin dihydrochloride 69-44-3
Price
US $30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000t/year
Release date
2023-09-07
Handan Tongyi New Material Technology Co., Ltd
Product
Acrichin dihydrochloride 69-44-3
Price
US $1.00/Kg
Min. Order
1KG
Purity
99.99%
Supply Ability
500 Metric Ton/Day
Release date
2021-03-01

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