ChemicalBook > CAS DataBase List > 2-METHOXYMETHYL METHANSULFONATE

2-METHOXYMETHYL METHANSULFONATE

Product Name
2-METHOXYMETHYL METHANSULFONATE
CAS No.
16427-44-4
Chemical Name
2-METHOXYMETHYL METHANSULFONATE
Synonyms
2-Methoxymethyl Methansulfonate;2-METHOXYETHYL METHANESULFONATE;2-MethoxyethylMethanesulfonate>Ethanol, 2-methoxy-, 1-methanesulfonate;METHANESULFONIC ACID 2-METHOXYETHYL ESTER
CBNumber
CB8162926
Molecular Formula
C4H10O4S
Formula Weight
154.18
MOL File
16427-44-4.mol
More
Less

2-METHOXYMETHYL METHANSULFONATE Property

Boiling point:
126 °C / 12mmHg
Density 
1.25
refractive index 
1.4300-1.4340
storage temp. 
Sealed in dry,Room Temperature
form 
clear liquid
color 
Colorless to Light yellow to Light orange
More
Less

Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
HS Code 
2909199090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TCI Chemical
Product number
M1446
Product name
2-Methoxyethyl Methanesulfonate
Purity
>97.0%(GC)
Packaging
5g
Price
$104
Updated
2025/07/31
TCI Chemical
Product number
M1446
Product name
2-Methoxyethyl Methanesulfonate
Purity
>97.0%(GC)
Packaging
25g
Price
$301
Updated
2025/07/31
TRC
Product number
M226180
Product name
2-MethoxymethylMethansulfonate
Packaging
25g
Price
$165
Updated
2021/12/16
Matrix Scientific
Product number
096202
Product name
2-Methoxyethyl methanesulfonate
Purity
95+%
Packaging
10g
Price
$168
Updated
2021/12/16
AK Scientific
Product number
8345AA
Product name
2-Methoxyethyl Methanesulfonate
Packaging
25g
Price
$370
Updated
2021/12/16
More
Less

2-METHOXYMETHYL METHANSULFONATE Chemical Properties,Usage,Production

Uses

2-Methoxymethyl Methansulfonate is used in the ring-opening polymerization of lactide. Also used in the synthesis of acetylcholine receptor ligands.

Synthesis

109-86-4

124-63-0

16427-44-4

GENERAL STEPS: To a cooled solution of 2-methoxyethanol (0.8 mL) in dichloromethane (50 mL) at 0°C, methylsulfonyl chloride (1.3 mL) and triethylamine (2 mL) were added slowly and dropwise. After 5 minutes of reaction, the ice bath was removed and the reaction mixture was gradually warmed to room temperature with continuous stirring for 1 hour. Upon completion of the reaction, the reaction mixture was washed sequentially with 1.0 N NaOH solution and saturated saline, followed by drying with anhydrous magnesium sulfate and concentration under reduced pressure to give 2-methoxyethyl methane sulfonate as an oil in quantitative yield. Mass spectrum (ESI+) m/z 155.1 ([M+H]+), molecular formula C4H10O4S. 2-Methoxyethyl methane sulfonate (1.54 g) was dissolved in 2-butanone (150 mL) and cesium carbonate (6.50 g) and 3-fluoro-4-nitrophenol (1.52 g) were added. The reaction mixture was refluxed for 19 h. After cooling, it was filtered, concentrated under reduced pressure and purified by silica gel column chromatography (eluent: ethyl acetate/heptane) to give the target product in 98% yield.1H NMR (400 MHz, DMSO-d6) δ 7.95, 6.82, 6.67, 4.25, 3.92, 3.68, 3.33, 3.31. 2-Methoxy-4-(2-methoxyethoxy)-1-nitrobenzene (2.0 g) was dissolved in methanol (200 mL) and 10% Pd/C (1.0 g) and HCl (1.8 g) were added. The reaction was shaken at 40 psi hydrogen pressure for 15 minutes. After completion of the reaction, the reaction mixture was filtered and the filtrate was crystallized by ethanol/ether to give 2-methoxy-4-(2-methoxyethoxy)aniline hydrochloride in 76% yield. Mass spectrum (ESI+) m/z 198.1 ([M+H]+), molecular formula C10H15NO3. Example 156 was prepared from 2-methoxy-4-(2-methoxyethoxy)aniline hydrochloride and 2-isocyanato-5-(trifluoromethyl)-1,3,4-thiadiazole according to Method B in 50% yield. High resolution mass spectrometry (HRMS, ESI) calculated value C14H15N4O4SF3+H 393.0844 and measured value 393.0838.

References

[1] Patent: US2003/236287, 2003, A1. Location in patent: Page 38, 39
[2] Patent: US2003/236287, 2003, A1. Location in patent: Page 41
[3] Molecules, 2013, vol. 18, # 8, p. 9603 - 9622
[4] Patent: US2017/2028, 2017, A1. Location in patent: Paragraph 0162; 0163
[5] Chemistry - A European Journal, 2013, vol. 19, # 4, p. 1346 - 1356

2-METHOXYMETHYL METHANSULFONATE Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

2-METHOXYMETHYL METHANSULFONATE Suppliers

Americas 1 Belgium 1 Canada 2 China 69 Europe 1 Germany 2 India 5 Japan 2 United States 16 Global 99
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Ark Pharm, Inc.
Tel
847-367-3680
Fax
847-367-3681
Email
sales@arkpharminc.com
Country
United States
ProdList
1670
Advantage
56
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Shandong Xiya Chemical Co., Ltd
Tel
4009903999 13355009207
Fax
0539-6365991
Email
3007715519@qq.com
Country
China
ProdList
18729
Advantage
57
Tianjin Derchemist Science & Technology Co., Ltd.
Tel
22-58627059 13920586291
Fax
022-58620305
Email
zdcomcon@126.com
Country
China
ProdList
3829
Advantage
50
TOKYO CHEMICAL INDUSTRY CO., LTD.
Tel
03-36680489
Fax
03-3668-0520
Email
Sales-JP@TCIchemicals.com
Country
Japan
ProdList
28387
Advantage
80
More
Less

View Lastest Price from 2-METHOXYMETHYL METHANSULFONATE manufacturers

Career Henan Chemical Co
Product
2-METHOXYMETHYL METHANSULFONATE 16427-44-4
Price
US $1.00/KG
Min. Order
1g
Purity
99.0%
Supply Ability
100kg
Release date
2020-01-10

16427-44-4, 2-METHOXYMETHYL METHANSULFONATERelated Search:

5'-Tosyladenosine (-)-1,4-DI-O-TOSYL-2,3-O-ISOPROPYLIDENETHREITOL (R)-(+)-1-BENZOYLOXY-2-BENZYLOXY-3-TOSYLOXYPROPANE (R)-(-)-Glycidyl nosylate Tri(Ethylene Glycol) DI-P-Toluenesulfonate PENTA(ETHYLENE GLYCOL) DI-P-TOLUENESULFONATE Methyl 2,3-O-isopropylidene-5-O-(p-tolylsulfonyl)-beta-D-ribofuranoside 2'-TOSYLADENOSINE DIETHYLENE GLYCOL BIS(P-TOLUENESULFONATE) 2-METHOXYETHYL P-TOLUENESULFONATE (R)-(-)-2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE (2R)-(-)-Glycidyl tosylate TATM 1,6-ANHYDRO-3,4-O-ISOPROPYLIDENE-2-TOSYL-B-D-GALACTOPYRANOSE 5-O-CARBOMETHOXY-1,2-O-ISO-PROPYLIDENE-3-O-(P-TOLYL-SULFONYL)-ALPHA-D-XYLOFURANOSE 2,2-DIMETHYL-1,3-DIOXOLAN-4-YLMETHYL P-TOLUENESULFONATE 1,2-O-Isopropylidene-5-O-p-toluenesulfonyl-a-D-xylofuranose METHYL 6-O-TOSYL-ALPHA-D-GLUCOPYRANOSIDE

  • 2-METHOXYETHYL METHANESULFONATE
  • METHANESULFONIC ACID 2-METHOXYETHYL ESTER
  • 2-Methoxymethyl Methansulfonate
  • 2-MethoxyethylMethanesulfonate&gt
  • Ethanol, 2-methoxy-, 1-methanesulfonate
  • 16427-44-4