ChemicalBook > CAS DataBase List > 2-Methoxy-3-(trifluoromethyl)pyridine

2-Methoxy-3-(trifluoromethyl)pyridine

storage Uses

Product Name: 2-Methoxy-3-(trifluoromethyl)pyridine
CAS No.: 121643-44-5
Chemical Name: 2-Methoxy-3-(trifluoromethyl)pyridine
Synonyms: BUTTPARK 45\01-90;METHOXY-3-TRIFLUOROMETHYLPYRIDINE;2-Bromo-7-(trifluoromethyl)pyridine;2-METHOXY-3-(TRIFLUOROMETHYL)PYRIDINE;3-(trifluoroMethyl)-2-Methoxypyridine;2-Methoxy-3-(trifluoromethyl)pyridine>2-Methoxy-3-(trifluoromethyl)pyridine98%;2-Methoxy-3-(trifluoromethyl)pyridine 98%;2-Methoxy-3-(trifluoromethyl)pyridine ISO 9001：2015 REACH
CBNumber: CB8181415
Molecular Formula: C7H6F3NO
Formula Weight: 177.12
MOL File: 121643-44-5.mol

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2-Methoxy-3-(trifluoromethyl)pyridine Property

Boiling point:: 44 °C
Density: 1.297 g/mL at 25 °C
refractive index: n20/D 1.441
Flash point:: 118 °F
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: soluble in Methanol
form: clear liquid
pka: 0.97±0.10(Predicted)
color: Colorless to Almost colorless
InChI: InChI=1S/C7H6F3NO/c1-12-6-5(7(8,9)10)3-2-4-11-6/h2-4H,1H3
InChIKey: SSAZZVQVJJXPMB-UHFFFAOYSA-N
SMILES: C1(OC)=NC=CC=C1C(F)(F)F
CAS DataBase Reference: 121643-44-5(CAS DataBase Reference)

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Safety

Hazard Codes: T,Xi,Xn
Risk Statements: 10-25-36/37/38-20/21/22
Safety Statements: 16-26-45-36
RIDADR: UN 1992 3/PG 3
WGK Germany: 3
HazardClass: IRRITANT
PackingGroup: III
HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H226Flammable liquid and vapour

H300Fatal if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 658359
Product name: 2-Methoxy-3-(trifluoromethyl)pyridine
Purity: 96%
Packaging: 5g
Price: $86.1
Updated: 2023/06/20

TCI Chemical

Product number: M2191
Product name: 2-Methoxy-3-(trifluoromethyl)pyridine
Purity: >98.0%(GC)
Packaging: 1g
Price: $34
Updated: 2024/03/01

TCI Chemical

Product number: M2191
Product name: 2-Methoxy-3-(trifluoromethyl)pyridine
Purity: >98.0%(GC)
Packaging: 5g
Price: $114
Updated: 2025/07/31

TRC

Product number: M271975
Product name: 2-Methoxy-3-(trifluoromethyl)pyridine
Packaging: 1g
Price: $75
Updated: 2021/12/16

Oakwood

Product number: 006761
Product name: 2-Methoxy-3-(trifluoromethyl)pyridine
Purity: 98%
Packaging: 1g
Price: $10
Updated: 2021/12/16

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2-Methoxy-3-(trifluoromethyl)pyridine Chemical Properties,Usage,Production

storage

2-Methoxy-3-(trifluoromethyl)pyridine store at room temperature.

Uses

2-Methoxy-3-(trifluoromethyl)pyridine belongs to pyridine derivatives and can be used as pharmaceutical intermediates.

Synthesis

124-41-4

65753-47-1

121643-44-5

2-Chloro-3-trifluoromethylpyridine (3 g, 16.53 mmol) was dissolved in 30 mL of a methanol solution of sodium methanolate (5.4 M). The reaction mixture was stirred at room temperature for 48 hours. After completion of the reaction, the mixture was cooled in an ice bath and extracted three times with dichloromethane (DCM). The organic phases were combined, washed with saturated sodium chloride solution and dried over anhydrous magnesium sulfate. The organic phase was concentrated under reduced pressure to afford 2-methoxy-3-trifluoromethylpyridine as a colorless liquid (2.7 g, 89% yield). The product was characterized by 1H-NMR (400 MHz, DMSO-d6, 298 K): δ 3.98 (s, 3H), 7.2 (dd, 1H), 8.11 (d, 1H), 8.45 (d, 1H). Mass Spectrometry (MS): m/z 178.1 [M+1]+, retention time (Rt) = 1.29 min.

References

[1] Patent: WO2013/57711, 2013, A1. Location in patent: Page/Page column 45-46
[2] Patent: WO2013/88404, 2013, A1. Location in patent: Page/Page column 92
[3] Patent: US2015/342951, 2015, A1. Location in patent: Paragraph 0841-0842

2-Methoxy-3-(trifluoromethyl)pyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Methoxy-3-(trifluoromethyl)pyridine manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 2-Methoxy-3-(trifluoromethyl)pyridine 121643-44-5
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-11-28

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-Methoxy-3-(trifluoromethyl)pyridine 121643-44-5
Price: US $2.20-8.80/kg
Min. Order: 1kg
Purity: 99%min
Supply Ability: 1000kg
Release date: 2025-06-13

PNP Biotech Co. Ltd

Product: 2-Methoxy-3-(trifluoromethyl)pyridine 121643-44-5
Price: US $0.00/kg
Min. Order: 25kg
Purity: 98%
Supply Ability: Inquiry
Release date: 2023-07-10

121643-44-5, 2-Methoxy-3-(trifluoromethyl)pyridineRelated Search:

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2-Methoxy-3-(trifluoromethyl)pyridine 98%

2-Methoxy-3-(trifluoromethyl)pyridine98%

BUTTPARK 45\01-90

METHOXY-3-TRIFLUOROMETHYLPYRIDINE

3-(trifluoroMethyl)-2-Methoxypyridine

2-METHOXY-3-(TRIFLUOROMETHYL)PYRIDINE

2-Methoxy-3-(trifluoromethyl)pyridine&gt

2-Bromo-7-(trifluoromethyl)pyridine

2-Methoxy-3-(trifluoromethyl)pyridine ISO 9001：2015 REACH

121643-44-5

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