2-CHLORO-3-FLUOROBENZOIC ACID
- Product Name
- 2-CHLORO-3-FLUOROBENZOIC ACID
- CAS No.
- 102940-86-3
- Chemical Name
- 2-CHLORO-3-FLUOROBENZOIC ACID
- Synonyms
- CAS:102940-86-3;BUTTPARK 19\01-64;2-Chloro-3-Fluorobenzoic;2-CHLORO-3-FLUOROBENZOIC ACID;Benzoic acid,2-chloro-3-fluoro-;2-Chloro-3-fluorobenzoic Acid >
- CBNumber
- CB8194727
- Molecular Formula
- C7H4ClFO2
- Formula Weight
- 174.56
- MOL File
- 102940-86-3.mol
2-CHLORO-3-FLUOROBENZOIC ACID Property
- Melting point:
- 171 °C
- Boiling point:
- 279.5±20.0 °C(Predicted)
- Density
- 1.477±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- form
- powder to crystal
- pka
- 2.56±0.25(Predicted)
- color
- White to Almost white
- CAS DataBase Reference
- 102940-86-3(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-22
- Safety Statements
- 26-36/37/39-37
- HazardClass
- IRRITANT
- HS Code
- 29163990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- C2128
- Product name
- 2-Chloro-3-fluorobenzoic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 1g
- Price
- $27
- Updated
- 2025/07/31
- Product number
- C2128
- Product name
- 2-Chloro-3-fluorobenzoic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $80
- Updated
- 2025/07/31
- Product number
- C364830
- Product name
- 2-Chloro-3-fluorobenzoic Acid
- Packaging
- 25g
- Price
- $385
- Updated
- 2021/12/16
- Product number
- 002345
- Product name
- 2-Chloro-3-fluorobenzoic acid
- Purity
- 95%
- Packaging
- 1g
- Price
- $9
- Updated
- 2021/12/16
- Product number
- 005185
- Product name
- 2-Chloro-3-fluorobenzoic Acid
- Purity
- 98%
- Packaging
- 1g
- Price
- $10
- Updated
- 2021/12/16
2-CHLORO-3-FLUOROBENZOIC ACID Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
2-Chloro-3-fluorobenzoic Acid is a useful synthetic intermediate. It can be used to synthesize aminobenzhydrol derivatives containing pendant cyclic amines as inhibitors of squalene synthase and cholesterol synthase. It can also be used to prepare aryl aminopyrazole benzamides as oral non-steroidal selective glucocorticoid receptor agonists.
Synthesis
455-38-9
102940-86-3
General procedure for the synthesis of 2-chloro-3-fluorobenzoic acid from m-fluorobenzoic acid: 1. 3-Fluorobenzoic acid (4.02 g, 28.71 mmol) was dissolved in 20 mL of tetrahydrofuran (THF) to prepare a solution. 2. the above solution was slowly added dropwise to a suspension containing tetramethylene diamine (TMEDA) (10.00 mL, 66.3 mmol) and 1.3 M sec-butyllithium (sec-BuLi) (48 mL, 62.4 mmol) at -90 °C. the solution was then dissolved in 20 mL of tetrahydrofuran (THF) to form a solution. 3. 50 mL of THF was added to dilute the reaction mixture, maintaining the temperature at -90°C with continuous stirring for 35 minutes. 4. The reaction mixture was slowly warmed to -78°C followed by the addition of a solution of hexachloroethane (27.0 g, 113.9 mmol) in 50 mL of THF. 5. After the reaction had proceeded for 20 h, the reaction was quenched with water and the reaction mixture was diluted with ether. 6. The pH of the reaction mixture was adjusted to 1-2 using concentrated hydrochloric acid (HCl) to promote stratification. 7. The organic layer was separated, washed sequentially with water and brine, then dried and concentrated to give 30.4 g of crude product (tan solid). 8. The crude product was washed with hexane to yield 3.728 g (74% yield) of the target product 2-chloro-3-fluorobenzoic acid (1a) as a light tan solid. Mass spectrometry (MS) analysis showed m/z 175.2 (M + H).
References
[1] Patent: WO2004/39775, 2004, A2. Location in patent: Page 12
[2] Patent: WO2009/39091, 2009, A1. Location in patent: Page/Page column 13
[3] Patent: WO2007/150015, 2007, A2. Location in patent: Page/Page column 5
[4] Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1995, # 10, p. 1265 - 1272
[5] Bulletin de la Societe Chimique de France, 1996, vol. 133, # 2, p. 133 - 141
2-CHLORO-3-FLUOROBENZOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2-CHLORO-3-FLUOROBENZOIC ACID Suppliers
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- The Netherlands
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View Lastest Price from 2-CHLORO-3-FLUOROBENZOIC ACID manufacturers
- Product
- 2-CHLORO-3-FLUOROBENZOIC ACID 102940-86-3
- Price
- US $10.00-8.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-06
- Product
- 2-Chloro-3-fluorobenzoic acid 102940-86-3
- Price
- US $410.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 300MT/year
- Release date
- 2019-12-24
- Product
- 2-CHLORO-3-FLUOROBENZOIC ACID 102940-86-3
- Price
- US $0.10/KG
- Min. Order
- 0.1KG
- Purity
- 99%
- Supply Ability
- 2000TONS
- Release date
- 2019-12-24