Fmoc-Gly-Gly-OH

Product Name: Fmoc-Gly-Gly-OH
CAS No.: 35665-38-4
Chemical Name: Fmoc-Gly-Gly-OH
Synonyms: Fmoc-G-G;FMoc-Gly4;FMoc-Gly-Gly;FMOC-GLY-GLY-OH;FMOC-GLYCYL-GLYCINE;N-Fmoc-glycylglycine;N-Fmoc-L-glycylglycine;REF DUPL: Fmoc-Gly-Gly-OH;Fmoc-Gly-Gly-OH USP/EP/BP;N-Fmoc-L-glycylglycine，98%
CBNumber: CB8211408
Molecular Formula: C19H18N2O5
Formula Weight: 354.36
MOL File: 35665-38-4.mol

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Fmoc-Gly-Gly-OH Property

Melting point:: 176-177 °C
Boiling point:: 684.1±45.0 °C(Predicted)
Density: 1.338±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
pka: 3.39±0.10(Predicted)
form: Powder
color: White
InChI: InChI=1S/C19H18N2O5/c22-17(20-10-18(23)24)9-21-19(25)26-11-16-14-7-3-1-5-12(14)13-6-2-4-8-15(13)16/h1-8,16H,9-11H2,(H,20,22)(H,21,25)(H,23,24)
InChIKey: FBKUOPULLUJMOC-UHFFFAOYSA-N
SMILES: C(O)(=O)CNC(=O)CNC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O

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Safety

HS Code: 2924297099

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

TCI Chemical

Product number: F1234
Product name: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycylglycine
Packaging: 5G
Price: $42
Updated: 2025/07/31

TCI Chemical

Product number: F1234
Product name: N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycylglycine
Packaging: 25G
Price: $164
Updated: 2025/07/31

TRC

Product number: F620170
Product name: Fmoc-Gly-Gly-OH
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Usbiological

Product number: 277234
Product name: Fmoc-Gly-Gly-OH
Packaging: 1g
Price: $372
Updated: 2021/12/16

BroadPharm

Product number: BP-25472
Product name: Mal-Cyclohexyl-PEG3-Biotin
Purity: 98%
Packaging: 25g
Price: $380
Updated: 2021/12/16

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Fmoc-Gly-Gly-OH Chemical Properties,Usage,Production

Description

Fmoc-Gly-Gly-OH is a peptide linker. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations.

Chemical Properties

White powder

Uses

Fmoc-Gly-Gly-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

Synthesis

556-50-3

28920-43-6

35665-38-4

General procedure for the synthesis of N-fluorenylmethoxycarbonyl-glycyl-glycine from bisglycopeptide and chloroformic acid-9-fluorenylmethyl ester: 15 mL of dioxane was added to a mixture of bisglycopeptide (1 mmol) and chloroformic acid-9-fluorenylmethyl ester (1.2 mmol), cooled to 0 °C and then an equal volume of a 1N Na2CO3 solution was slowly added. The reaction mixture was stirred at room temperature for 12 hours. The progress of the reaction was monitored by thin layer chromatography (TLC) and after confirming the completion of the reaction, the reaction solution was acidified to pH 4-5 with 1 M HCl. The reaction mixture was extracted with ethyl acetate (3 x 70 mL) at 0 °C. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure to afford pure N-fluorenylmethoxycarbonyl-glycyl-glycine in 89% yield.

IC 50

Cleavable Linker

References

[1] Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337. DOI:10.1038/nrd.2016.268

Fmoc-Gly-Gly-OH Preparation Products And Raw materials

Raw materials

Preparation Products

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Fmoc-Gly-Gly-OH Suppliers

Americas 1 China 227 Europe 1 Germany 4 India 4 Japan 2 Switzerland 1 United States 13 Global 253

Chengdu Tachem Co., Ltd

Tel: 19983060238
Email: sales@tachem.cn
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Shanghai Kaipu New Biotechnology Co. , Ltd.

Tel: 17821452002; 17821452002
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Gill polypeptide biopharmaceutical (dalian) co., LTD

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SICHUAN TONGSHENG BIOPHARMACEUTICAL CO., LTD

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CHENGDU AMBOSYNTH CO., LTD.,

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TCI (Shanghai) Development Co., Ltd.

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Energy Chemical

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Beijing Ouhe Technology Co., Ltd

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Jia Xing Isenchem Co.,Ltd

Tel: 0573-85285100 18627885956
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Accela ChemBio Co.,Ltd.

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View Lastest Price from Fmoc-Gly-Gly-OH manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd

Product: Fmoc-Gly-Gly-OH 35665-38-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1T+
Release date: 2024-02-04

Zibo Hangyu Biotechnology Development Co., Ltd

Product: Fmoc-Gly-Gly-OH 35665-38-4
Price: US $80.00-800.00/KG
Min. Order: 10KG
Purity: 0.99
Supply Ability: 20tons
Release date: 2023-10-27

Xian confluore Biological Technology Co., Ltd.

Product: Fmoc-Gly-Gly-OH 35665-38-4
Price: US $0.00/g
Min. Order: 500g
Purity: >95.00%
Supply Ability: 500g
Release date: 2024-04-01

35665-38-4, Fmoc-Gly-Gly-OHRelated Search:

4-Hydroxy-D-(-)-2-phenylglycine Fmoc-Aib-OH 4-Aminophenylacetic acid Glycine N-Carbobenzyloxyglycine Glycylglycine 9-Fluorenylmethyl chloroformate METHOXYFENOZIDE Fmoc-Gly-OH Fmoc-OSu Fmoc FMOC-ALA-ALA-OH Fmoc-Pro-Pro-OH FMOC-LYS(BOC)-LEU-OH FMOC-ALA-PRO-OH FMOC-NLE-NLE-OH FMOC-SER(TBU)-THR(TBU)-OH FMOC-PHE-ARG-OH

N-9-Fluorenylmethoxycarbonylglycylglycine

FMOC-GLYCYL-GLYCINE

FMOC-GLY-GLY-OH

N-[(9H-Fluoren-9-ylmethoxy)carbonyl]glycyl-glycine

2-(2-(((9H-fluoren-9-yl)methoxy)carbonylamino)acetamido)acetic acid

REF DUPL: Fmoc-Gly-Gly-OH

FMoc-Gly-Gly

FMoc-Gly4

Fmoc-Gly-Gly-OH≥ 99% (HPLC)

N-Fmoc-L-glycylglycine

(9H-Fluoren-9-yl)MethOxy]Carbonyl Gly-Gly-OH

N-Fmoc-glycylglycine

(((9H-Fluoren-9-yl)methoxy)carbonyl)glycylglycine

[({[(9H-fluoren-9-ylmethoxy)carbonyl]amino}acetyl)amino]acetic acid

Glycine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]glycyl-

2-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]acetic acid

2-[[2-(9H-fluoren-9-ylmethoxycarbonylamino)acetyl]amino]aceticaci

Fmoc-Gly-Gly-OH USP/EP/BP

N-Fluorene methoxycarbonyl-glycyl-glycine

N-Fmoc-L-glycylglycine, 97%

N-Fmoc-L-glycylglycine，98%

Fmoc-G-G

35665-38-4

Amino Acid Derivatives

ADCs