tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate

Product Name: tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate
CAS No.: 414910-15-9
Chemical Name: tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate
Synonyms: Olapali impurity 9;Olaparib Impurity Z;Olapali impurity 21;Artemether Impurity 13;tert-Butyl 4-(cyclopropanecarbonyl);(4-Boc-1-piperazinyl)(cyclopropyl)methanone;ert-butyl4-(cyclopropanecarbonyl)piperazine-1-carboxylate;tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate;tert-butyl 4-(cyclopropanecarbonyl)piperazine-1-carboxylate;4-Cyclopropanoylpiperazine-1-carboxylic acid tert-butyl ester
CBNumber: CB82122010
Molecular Formula: C13H22N2O3
Formula Weight: 254.33
MOL File: 414910-15-9.mol

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tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate Property

Boiling point:: 388.4±35.0 °C(Predicted)
Density: 1.175±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: -0.25±0.70(Predicted)
Appearance: White to off-white Solid

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: C991524
Product name: 4-Cyclopropanoylpiperazine-1-carboxylicAcidtert-ButylEster
Packaging: 100mg
Price: $70
Updated: 2021/12/16

TRC

Product number: C991524
Product name: 4-Cyclopropanoylpiperazine-1-carboxylicAcidtert-ButylEster
Packaging: 250mg
Price: $140
Updated: 2021/12/16

TRC

Product number: C991524
Product name: 4-Cyclopropanoylpiperazine-1-carboxylicAcidtert-ButylEster
Packaging: 500mg
Price: $235
Updated: 2021/12/16

ChemScene

Product number: CS-M1240
Product name: tert-Butyl4-(cyclopropanecarbonyl)piperazine-1-carboxylate
Purity: 99.23%
Packaging: 10g
Price: $279
Updated: 2021/12/16

AK Scientific

Product number: 5714AB
Product name: tert-Butyl4-(cyclopropanecarbonyl)piperazine-1-carboxylate
Packaging: 5g
Price: $788
Updated: 2021/12/16

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tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate Chemical Properties,Usage,Production

Uses

4-Cyclopropanoylpiperazine-1-carboxylic Acid tert-Butyl Ester is a useful reagent for organic synthesis and other chemical processes. It is used as a reagent in the preparation of propanoyl-quinazolinone scaffold-based novel PARP1 inhibitors.

Synthesis

4023-34-1

57260-71-6

414910-15-9

S1: In a 20L four-necked flask equipped with a mechanical stirrer and a thermometer, N-Boc-piperazine (1.82 kg, 9.77 mol), triethylamine (1.48 kg, 14.66 mol), and dichloromethane (5.46 kg) were added, and the mixture was cooled to 0 °C. Cyclopropanecarbonyl chloride (1.12 kg, 10.75 mol) was slowly added dropwise while maintaining the temperature from 0 °C to 10 °C. After the dropwise addition was completed, the reaction mixture was stirred at 10°C to 20°C for 3 hours. After completion of the reaction, 5 kg of water was added and the pH was adjusted to 8-9 with sodium carbonate. the organic and aqueous phases were separated and the organic phase was collected. Extract again with 1.50kg of aqueous phase and combine all dichloromethane phases. The combined organic phases were washed sequentially with 2 kg of 0.05 M dilute hydrochloric acid and 2 kg of water. The dichloromethane phase was concentrated to give tert-butyl 4-(cyclopropanecarbonyl)piperazine-1-carboxylate (2.43 kg, 98% yield). The NMR spectrum was consistent with the standard spectrum.

References

[1] Patent: CN108341792, 2018, A. Location in patent: Paragraph 0028; 0033
[2] Patent: US2010/35883, 2010, A1. Location in patent: Page/Page column 56
[3] Patent: WO2011/130661, 2011, A1. Location in patent: Page/Page column 102
[4] Patent: US2004/14770, 2004, A1. Location in patent: Page/Page column 11

tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate Preparation Products And Raw materials

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View Lastest Price from tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate manufacturers

Career Henan Chemical Co

Product: tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate 414910-15-9
Price: US $1.00/kg
Min. Order: 1kg
Purity: 95%-99%
Supply Ability: 100kg
Release date: 2018-12-20

414910-15-9, tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylateRelated Search:

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tert-butyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate

tert-butyl 4-(cyclopropanecarbonyl)piperazine-1-carboxylate

4-(cyclopropylcarbonyl)-1-Piperazinecarboxylic acid 1,1-dimethylethyl ester

4-Cyclopropanoylpiperazine-1-carboxylic acid tert-butyl ester

tert-Butyl 4-(cyclopropanecarbonyl)

(4-Boc-1-piperazinyl)(cyclopropyl)methanone

1-Piperazinecarboxylic acid, 4-(cyclopropylcarbonyl)-, 1,1-dimethylethyl ester

Olaparib Impurity Z

ert-butyl4-(cyclopropanecarbonyl)piperazine-1-carboxylate

Olapali impurity 9

1,1-Dimethylethyl 4-(cyclopropylcarbonyl)-1-piperazinecarboxylate

Artemether Impurity 13

tert-Butyl 4-(cyclopropanecarbonyl)piperazine-1-carboxylate (Olaparib Impurity)

Olapali impurity 21

414910-15-9