ChemicalBook > CAS DataBase List > Ethyl (R)-3-hydroxybutyrate

Ethyl (R)-3-hydroxybutyrate

Product Name
Ethyl (R)-3-hydroxybutyrate
CAS No.
24915-95-5
Chemical Name
Ethyl (R)-3-hydroxybutyrate
Synonyms
grape butyrate;(R)-grape butyrate;2-ethyl-3-hydroxybutanoate;ETHYL (R)-3-HYDROXYBUTYRATE;ETHYL (R)-3-HYDROXYBUTYLATE;ethyl (3R)-3-hydroxybutanoate;ETHYL R-(-)-3-HYDROXYBUTANOATE;(R)-(-)-Ethyl 3-Hydrobutyrate;Ethyl (R)-3-hydroxybutyrate,98%;ETHYL (R)-(-)-3-HYDROXYBUTYRATE
CBNumber
CB8214494
Molecular Formula
C6H12O3
Formula Weight
132.16
MOL File
24915-95-5.mol
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Ethyl (R)-3-hydroxybutyrate Property

alpha 
-45.5 º (589nm, c=1, CHCl3)
Boiling point:
75-76 °C/12 mmHg (lit.)
Density 
1.017 g/mL at 25 °C (lit.)
vapor pressure 
17.2Pa at 20℃
refractive index 
n20/D 1.42(lit.)
Flash point:
148 °F
storage temp. 
2-8°C
pka
14.45±0.20(Predicted)
form 
Liquid
color 
Clear, Colorless
Specific Gravity
1.017
optical activity
[α]20/D 46°, c = 1 in chloroform
Water Solubility 
soluble
LogP
0.341 at 20℃
CAS DataBase Reference
24915-95-5(CAS DataBase Reference)
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Safety

Risk Statements 
36/37/38-52
Safety Statements 
24/25
RIDADR 
1993
WGK Germany 
3
HS Code 
29181990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H227Combustible liquid

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P403+P235Store in a well-ventilated place. Keep cool.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
347329
Product name
Ethyl (R)-(?)-3-hydroxybutyrate
Purity
98%
Packaging
1g
Price
$10.64
Updated
2024/03/01
Sigma-Aldrich
Product number
347329
Product name
Ethyl (R)-(?)-3-hydroxybutyrate
Purity
98%
Packaging
5g
Price
$51.48
Updated
2024/03/01
TCI Chemical
Product number
H1029
Product name
Ethyl (R)-(-)-3-Hydroxybutyrate
Purity
>98.0%(GC)
Packaging
1g
Price
$64
Updated
2024/03/01
TCI Chemical
Product number
H1029
Product name
Ethyl (R)-(-)-3-Hydroxybutyrate
Purity
>98.0%(GC)
Packaging
5g
Price
$132
Updated
2024/03/01
Alfa Aesar
Product number
J63400
Product name
Ethyl (R)-(-)-3-hydroxybutyrate
Packaging
5g
Price
$129
Updated
2021/12/16
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Ethyl (R)-3-hydroxybutyrate Chemical Properties,Usage,Production

Description

Ethyl (R)-(-)-3-Hydroxybutyrate is a chiral starting material for the production of numerous biologically active compounds.

Chemical Properties

clear colorless liquid

Uses

Ethyl (R)-(-)-3-hydroxybutyrate is a chiral building block for the preparation of bioactive compounds used in the pharmaceutical industry. It is formed during the hydrolysis of poly-3-hydroxybutyrate.

Definition

ChEBI: Ethyl (R)-3-hydroxybutanoate is an ethyl 3-hydroxybutyrate. It is functionally related to a (R)-3-hydroxybutyric acid.

General Description

Ethyl (R)-3-hydroxybutyrate is an enantiomer of 3-hydroxybutyric acid. It is synthesized from diethyl succinate in a one-pot, stereoselective, high-yield process by using asymmetric synthesis and hydrogenation. The reaction vessel used for this synthesis is a reaction solution that has been optimized to be resistant to high pressure and temperature. This product can be used as a renewable feedstock in the production of polyesters and other polymers.

Synthesis

(R)-β-Butryrolactone (20 g, 230 mmol) was dissolved in 500 mLethanol with 1.0 mL H2SO4 and stirred at room temperature. Aliquots(100 μL) were added to 1.0 mL of methanol and analyzed by GC-MS for conversion of the lactone. Upon completion (> 48 h), a small amount of solid sodium bicarbonate was added and the solvent removed by rotary evaporation. The residue was taken up in dichloromethane and washed with water. The water layer was extracted twice with ethyl acetate. The pooled organic layers were dried with magnesium sulfate, which was then filtered and the solvent removed by rotary evaporation to yield Ethyl (R)-3-hydroxybutyrate as a clear oil (20.2 g, 66%).

Ethyl (R)-3-hydroxybutyrate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl (R)-3-hydroxybutyrate Suppliers

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View Lastest Price from Ethyl (R)-3-hydroxybutyrate manufacturers

Hebei Chuanghai Biotechnology Co,.LTD
Product
Ethyl (R)-3-Hydroxybutyrate 24915-95-5
Price
US $5.00-2.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
10000kg
Release date
2024-08-15
Hebei Mojin Biotechnology Co., Ltd
Product
Ethyl (R)-3-hydroxybutyrate 24915-95-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2024-09-26
ChiRial Biomaterial Co Ltd
Product
Ethyl (R)-3-Hydroxybutyrate 24915-95-5
Price
US $0.00-0.00/g
Min. Order
1g
Purity
97%
Supply Ability
10 tons
Release date
2023-03-23

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