Ethyl S-4-chloro-3-hydroxybutyrate

Product Name: Ethyl S-4-chloro-3-hydroxybutyrate
CAS No.: 86728-85-0
Chemical Name: Ethyl S-4-chloro-3-hydroxybutyrate
Synonyms: ETHYL (S)-4-CHLORO-3-HYDROXYBUTANOATE;ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE;ETHYL (S)-(-)-4-CHLORO-3-HYDROXYBUTYRATE;SECHB;AST-4;PEFC-026;(S)-(?)-4-chL;(S)-Ethyl 4-chloro-3-;oro-3-hydroxybutyrate;4-chloro-3-hydroxyhexanoate
CBNumber: CB9448087
Molecular Formula: C6H11ClO3
Formula Weight: 166.6
MOL File: 86728-85-0.mol

More

Less

Ethyl S-4-chloro-3-hydroxybutyrate Property

alpha: -14.5 º (c=neat)
Boiling point:: 93-95 °C5 mm Hg(lit.)
Density: 1.19 g/mL at 25 °C(lit.)
refractive index: n20/D 1.453(lit.)
Flash point:: 109 °C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
form: Liquid
pka: 13.23±0.20(Predicted)
color: Clear colorless to yellow
optical activity: [α]23/D 14°, neat
BRN: 4657170
InChI: InChI=1S/C6H11ClO3/c1-2-10-6(9)3-5(8)4-7/h5,8H,2-4H2,1H3/t5-/m0/s1
InChIKey: ZAJNMXDBJKCCAT-YFKPBYRVSA-N
SMILES: C(OCC)(=O)C[C@H](O)CCl
CAS DataBase Reference: 86728-85-0(CAS DataBase Reference)

More

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 41-22
Safety Statements: 26-36-39
RIDADR: 2810
WGK Germany: 3
HazardClass: 6.1
PackingGroup: III
HS Code: 29181990

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 460524
Product name: Ethyl (S)-(?)-4-chloro-3-hydroxybutyrate
Purity: 96%
Packaging: 1g
Price: $15.48
Updated: 2024/03/01

Sigma-Aldrich

Product number: 460524
Product name: Ethyl (S)-(?)-4-chloro-3-hydroxybutyrate
Purity: 96%
Packaging: 5g
Price: $29.12
Updated: 2024/03/01

TCI Chemical

Product number: C1717
Product name: Ethyl (S)-4-Chloro-3-hydroxybutyrate
Purity: >95.0%(GC)
Packaging: 5g
Price: $47
Updated: 2024/03/01

TCI Chemical

Product number: C1717
Product name: Ethyl (S)-4-Chloro-3-hydroxybutyrate
Purity: >95.0%(GC)
Packaging: 25g
Price: $85
Updated: 2024/03/01

Alfa Aesar

Product number: L18554
Product name: Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate, 98%, ee 98%
Packaging: 1g
Price: $25.65
Updated: 2024/03/01

More

Less

Ethyl S-4-chloro-3-hydroxybutyrate Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liqui

Uses

Atorvastatin Intermediate

Uses

Ethyl (S)-(?)-4-chloro-3-hydroxybutyrate can be used as a starting material in the synthesis of 4-amino-3-hydroxybutyric acid, a compound of pharmacological importance.

Biosynthesis

Bioreductions catalyzed by alcohol dehydrogenases (ADHs) play an essential role in synthesizing chiral alcohols. A novel ADH, SmADH31, obtained from the Stenotrophomonas maltophilia genome, which can tolerate extremely high concentrations (6 M) of both substrate and product. The coexpression of SmADH31 and glucose dehydrogenase from Bacillus subtilis in Escherichia coli meant that as much as 660 g L–1 (4.0 M) ethyl 4-chloroacetoacetate was completely converted into ethyl (S)-4-chloro-3-hydroxybutyrate [(S)-CHBE] in a monophasic aqueous system with a >99.9% ee value and a high space-time yield (2664 g L–1 d–1). In the 100 ml-scale monophasic aqueous system (in triplicate), 66.0 g COBE (single batch charge) can be completely converted to (S)-CHBE (ee >99.9%) in only 6 h with 2 g of the SmADH31/GDH co-expressing cells. After extraction and evaporation, 61.6 g (S)-CHBE was isolated with 92% yield[1].

General Description

Ethyl (S)-4-chloro-3-hydroxybutanoate is a chiral intermediate generally used to prepare atorvastatin, a cholesterol-lowering drug.

References

[1] Zeyu Yang. “Efficient Asymmetric Synthesis of Ethyl (S)-4-Chloro-3-hydroxybutyrate Using Alcohol Dehydrogenase SmADH31 with High Tolerance of Substrate and Product in a Monophasic Aqueous System.” Organic Process Research & Development 24 6 (2020): 1068–1076.

Ethyl S-4-chloro-3-hydroxybutyrate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Ethyl S-4-chloro-3-hydroxybutyrate Suppliers

Americas 1 Belgium 2 Canada 2 China 343 Europe 2 France 2 Germany 9 India 16 Japan 9 Slovakia 1 South Korea 2 Switzerland 3 The Netherlands 1 United Kingdom 13 United States 41 Global 447

TaiZhou ZhiCheng Chemicals & Technology Co., LTD.

Tel: 0523-82837785 13365232216
Fax: 0523-87913272
Email: info@jszchg.com
Country: China
ProdList: 245
Advantage: 60

Hangzhou XunDa Bio-Technology Co., Ltd.

Tel: 0571-86932585
Fax: 0571-86932585
Email: xuandasales@163.com
Country: China
ProdList: 41
Advantage: 58

Taizhou Jiecheng Chemical Co., Ltd.

Tel: 0576-88203651 15967007102
Email: 103858443@qq.com
Country: China
ProdList: 190
Advantage: 58

Jiaxing Xinbelai Biotechnology Co., LTD

Tel: 18167156872
Email: guopeng@synbiolab.cn
Country: China
ProdList: 38
Advantage: 58

Shanghai Hongbang Pharmaceutical Co., Ltd.

Tel: 021-64975436 18917636693
Fax: 021-24280809
Email: 1377976036@qq.com
Country: China
ProdList: 299
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

PharmaBlock Sciences (Nanjing),Inc.

Tel: 400-0255188 4000255188
Fax: 86-025-86918232
Email: sales@pharmablock.com
Country: China
ProdList: 4986
Advantage: 55

Meryer (Shanghai) Chemical Technology Co., Ltd.

Tel: 021-61259108 18621169109
Fax: 86-21-61259102
Email: market03@meryer.com
Country: China
ProdList: 40240
Advantage: 62

JIANGXI AIFEIMU TECHNOLOGY CO.,LTD

Tel: 570-6040289 13735087952
Fax: +86-570-6259526
Email: sales@afmpharm.com
Country: China
ProdList: 96
Advantage: 61

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30132
Advantage: 84

More

Less

View Lastest Price from Ethyl S-4-chloro-3-hydroxybutyrate manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD

Product: Afatinib impurity 38 86728-85-0
Price: US $0.00-0.00/mg
Min. Order: 10mg
Purity: 98%
Supply Ability: 500mg
Release date: 2024-06-04

Henan Fengda Chemical Co., Ltd

Product: Ethyl S-4-chloro-3-hydroxybutyrate 86728-85-0
Price: US $8.00-3.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-03

Hangzhou ICH Biofarm Co., Ltd

Product: Ehyl-4-(-)chloro-3-hydroxybutyrate 86728-85-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1000
Release date: 2023-07-05

86728-85-0, Ethyl S-4-chloro-3-hydroxybutyrateRelated Search:

4-Cyanophenol 4-Hydroxybenzoic acid Ethyl acrylate Hydroxy silicone oil Ethyl acetate 2,3,4-Trihydroxybenzoic acid Ethyl isobutyrate Ethanol ETHYL 4-CHLOROBUTYRATE HYDROXYAPATITE TYPE I Ethyl butyrate Ethylbenzene Glycolic acid Ethyl formate Ethylparaben Ethyl 3-hydroxybutyrate 2,3,4,6-TETRA-O-PIVALOYL-ALPHA-D-GLUCOPYRANOSYL BROMIDE Acetoxy Empagliflozin

ethyl()-4-chloro-3-hydroxybutanoate

Ethyl(S)-4-chloro-3-hydroxybutylate

S-4-Chloro-3-hydroxybutyrate

ETHYL (S)-(-)-4-CHLORO-3-HYDROXYBUTANOATE

ETHYL (S)-4-CHLORO-3-HYDROXYBUTANOATE

(-)-ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE

ETHYL (S)-(-)-4-CHLORO-3-HYDROXYBUTYRATE

ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE

BUTANOIC ACID, 4-CHLORO-3-HYDROXY-, ETHYL ESTER, (S)

SECHB

Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate, 97% 1GR

)-4-chloro-3-hydroxybutyrate

(S)-Ethyl 4-chloro-3-

AST-4

Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate 96%

Butanoic acid,4-chloro-3-hydroxy-, ethyl ester, (3S)-

(S) - (-) - chlorine - 4-3 - hydroxy ethyl butyrate

Ethyl (3S)-(-)-4-chloro-3-hydroxybutyrate

(S)-(-)-ETHYL-4-CHLORO 3-HYDROXYBUTANOATE

(S)-ETHYL 4-CHLORO-3-HYDROXYBUTYRATE

(S)-(-)-4-CHLORO-3-HYDROXYBUTYRIC ACID ETHYL ESTER

(S)-4-CHLORO-3-HYDROXYBUTYRIC ACID ETHYL ESTER

Oxiracetam (S(-)-4-chloro-3-hydroxybutyric acid ethyl ester)

(S)-4-CHLORO-3-HYDROXY-N-BUTYRIC ACID ETHYL ESTER

Ehyl-4-(-)chloro-3-hydroxybutyrate

Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate, 96% (97% EE/GLC)

(2R,4R)-2,4-PENTANEDIOL EE 99+%

Ethyl(S)-(-)-4-chloro-3-Hydrox

ETHYL(S)-4-CHLORO-3-HYDROXY-BUTYRATE/ATS-4

ETHYL (S)-(-)-4-CHLORO-3-HYDROXYBUTYRATE , EE 98%

methyl 3S-4-chloro-3-hydroxybutanoate

Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate, 98%, ee 98%

Ethyl (3S)-4-chloro-3-hydroxybutanoate

Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate,97%

(S)-(-)-ethyl-4-chloro 3-hydroxybutanoate(ATS-4)

Ethyl (S)-(-)-4-chloro-3-hydroxybutyrate, 96%, ee 98%

Ethyl S-4-chloro-3-hydroxybutyate

4-chloro-3-hydroxyhexanoate

(S)-4-Chloro-3-Hydroxy-Butyric Acid Enthylester

PEFC-026

Ethyl (S)-4-Chloro-3-hydroxybutyrate &gt

(S)-(?)-4-chL

oro-3-hydroxybutyrate

(-)-ETHYL (S)-4-CHLORO-3-HYDROXYBUTYRATE

Butanoic acid, 4-chloro-3-hydroxy-, ethyl ester, (3S)- (9CI, ACI)

4-chloro-3-hydroxy-Butanoic acid ethyl ester (3S)- (9CI ACI)

(S)-4-Chloro-3-hydroxybutyric Acid Ethyl Ester(ATS-4)

(3S)-4-Chloro-3-hydroxy-butanoic acid ethyl ester

Ethyl-(S)-4 chloro-3-hydroxy-Butyrarte

Ethyl-S-(-)chloro-3-hydroxybutyrate

S (-) -4-chloro-3-hydroxybutyrate ethyl ester

86728-85-0

96728-85-0

C6H11ClO3

Organic Building Blocks

Esters

Asymmetric Synthesis

Chiral Building Blocks