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N-BOC-4,4'-BIPIPERIDINE

Product Name
N-BOC-4,4'-BIPIPERIDINE
CAS No.
171049-35-7
Chemical Name
N-BOC-4,4'-BIPIPERIDINE
Synonyms
tert-butyl 4-(piperidin-4-yl)piperidine-1-carboxylate;-bipiperidine;N-Boc-4,4’N-Boc-4,4'-bipiperidine;N-Boc-4,4'-Bipiperidine;1-Boc- 4,4\'-bipiperidine;4,4'-Bipiperidine, 1-BOC protected;N-Boc-4,4′-bipiperidine, CAS 171049-35-7;1-(tert-Butoxycarbonyl)-4,4'-bipiperidine;tert-Butyl 4,4'-bipiperidine-1-carboxylate
CBNumber
CB8221249
Molecular Formula
C15H28N2O2
Formula Weight
268.39
MOL File
171049-35-7.mol
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N-BOC-4,4'-BIPIPERIDINE Property

Boiling point:
363℃
Density 
1.028
Flash point:
173℃
storage temp. 
2-8°C(protect from light)
pka
10.38±0.10(Predicted)
form 
solid
color 
Cream
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Safety

Hazard Codes 
Xi
HazardClass 
IRRITANT
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B200895
Product name
N-Boc-4,4''-bipiperidine
Packaging
250mg
Price
$95
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB51004
Product name
N-Boc-4,4'-bipiperidine
Packaging
250mg
Price
$90
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB51004
Product name
N-Boc-4,4'-bipiperidine
Packaging
2g
Price
$300
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB51004
Product name
N-Boc-4,4'-bipiperidine
Packaging
500mg
Price
$120
Updated
2021/12/16
Matrix Scientific
Product number
045893
Product name
4-(4'-Piperid-1-yl)-1-tert-butoxycarbonyl-piperidine
Purity
>95%
Packaging
500mg
Price
$127
Updated
2021/12/16
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N-BOC-4,4'-BIPIPERIDINE Chemical Properties,Usage,Production

Synthesis

24424-99-5

78619-84-8

171049-35-7

The general procedure for the synthesis of tert-butyl [4,4'-bipiperidinyl]-1-carboxylate from di-tert-butyl dicarbonate and 4,4'-bipiperidinium dihydrochloride is as follows: 1. prepare 4-(4-piperidinyl)-1-piperidine carboxylic acid, 1,1-dimethylethyl ester (LXXXIX). 2. dissolve 41 g (0.17 mol) of 4,4'-bipiperidine dihydrochloride in 250 mL of ethanol and 250 mL of 2N sodium hydroxide solution. 3. 18.5 g (0.085 mol) of tert-butyl dicarbonate was slowly added to a 100 mL ethanol solution at 0°C. 4. The reaction mixture was stirred at 10 °C for 1 hour. 5. The ethanol was removed using a rotary evaporator. 6. The residual aqueous phase was saturated with sodium chloride and extracted with ethyl acetate. 7. The organic phases were combined, dried with magnesium sulfate and concentrated under reduced pressure. 8. The crude product was purified by silica gel column chromatography, the eluent being a mixture of dichloromethane/methanol/ammonia (8:2:0.4, v/v). 9. 16.5 g of the target compound tert-butyl [4,4'-bipiperidine]-1-carboxylate was finally obtained as a white solid in 72% yield, with a melting point of 70-71°C. The product was purified by silica gel column chromatography.

References

[1] Patent: US2006/178360, 2006, A1. Location in patent: Page/Page column 17
[2] Patent: US6008213, 1999, A
[3] Journal of Medicinal Chemistry, 2016, vol. 59, # 7, p. 3489 - 3498
[4] Patent: WO2017/83219, 2017, A1. Location in patent: Page/Page column 43; 44

N-BOC-4,4'-BIPIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BOC-4,4'-BIPIPERIDINE Suppliers

Canada 1 China 63 Germany 2 India 1 Japan 1 Switzerland 1 United Kingdom 6 United States 16 Global 91
Sumitomo Chemical Singapore Pte Ltd
Tel
--
Fax
--
Email
schp_contact@ya.sumitomo-chem.co.jp
Country
Japan
ProdList
175
Advantage
81
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View Lastest Price from N-BOC-4,4'-BIPIPERIDINE manufacturers

Career Henan Chemical Co
Product
N-BOC-4,4'-BIPIPERIDINE 171049-35-7
Price
US $0.01/KG
Min. Order
500g
Purity
98%; 99%
Supply Ability
500g；1kg； 10kg; 25kg
Release date
2020-01-08

171049-35-7, N-BOC-4,4'-BIPIPERIDINERelated Search:

N-BOC-2-(4-BROMO-PHENYL)-ETHYLAMINE N-BOC-4-PIPERIDINEACETALDEHYDE N-BOC-L-Arginine hydrochloride N-Boc-3-bromo-4-fluoroaniline N-Boc-2-piperidinecarboxylic acid N-Boc-3-Ethylpiperazine N-BOC-4,4-difluoro-L-proline N-Boc-5-amino-2-fluoropyridine 1-Boc-3-piperidinecarboxylic acid 1-Boc-3-hydroxypiperidine TERT-BUTYL 3-BROMOPHENETHYLCARBAMATE (3-IODO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER 1-N-Boc-3-Methylpiperidine-3-carboxylic acid N-Boc-cis-2,6-Diethyl-4-piperidone N-BOC-DL-SERINE TERT-BUTYL 4-(3-AMINOPROPYL)PIPERIDINE-1-CARBOXYLATE N-BOC-4,4'-BIPIPERIDINE Tert-butyl 3-(piperidin-4-yl)propylcarbamate

  • [4,4']BIPIPERIDINYL-1-CARBOXYLIC ACID TERT-BUTYL ESTER
  • 4-(4'-PIPERID-1-YL)-1-TERT-BUTOXYCARBONYL PIPERIDINE
  • N-(tert-Butoxycarbonyl)-4,4''-bipiperidine
  • tert-Butyl 4,4'-bipiperidine-1-carboxylate
  • tert-Butyl 4,4'-bipiperidine-1-carboxylate, 4-(tert-Butoxycarbonyl)-4-piperidin-4-ylpiperidine
  • [4,4'-Bipiperidine]-1-carboxylic acid 1,1-dimethylethyl ester
  • 1-(tert-Butoxycarbonyl)-4,4'-bipiperidine
  • 1,1-Dimethylethyl 4,4'-bipiperidine-1-carboxylate
  • 4-(4-Piperidinyl)-1-piperidinecarboxylic acid 1,1-dimethylethyl ester
  • 4,4'-Bipiperidine, 1-BOC protected
  • tert-Butyl 4,4'-bipiperidine-1-carboxylate, 1-(tert-Butoxycarbonyl)-4,4'-bipiperidine
  • tert-butyl 4-(piperidin-4-yl)piperidine-1-carboxylate
  • 1-Boc- 4,4\'-bipiperidine
  • 4-Piperidin-4-ylpiperidine, N-BOC protected
  • 4-(1-piperidinyl)-1-piperidinecarboxylic acid tert-butyl ester
  • -bipiperidine
  • N-Boc-4,4&rsquo
  • N-Boc-4,4'-bipiperidine
  • tert-Butyl [4,4'-bipiperidine]-1-carboxylate
  • tert-butyl 4-(4-piperidyl)piperidine-1-carboxylate
  • 4,4'Bipiperidinyl-1-carboxylic acid tert-butyl ester
  • N-Boc-4,4′-bipiperidine, CAS 171049-35-7
  • N-Boc-4,4'-Bipiperidine
  • 171049-35-7
  • C15H28N2O2
  • pharmacetical