4-(Pyridin-3-yl)pyrimidin-2-amine

Product Name: 4-(Pyridin-3-yl)pyrimidin-2-amine
CAS No.: 66521-66-2
Chemical Name: 4-(Pyridin-3-yl)pyrimidin-2-amine
Synonyms: 4-(PYRIDIN-3-YL)PYRIMIDIN-2-AMINE;BUTTPARK 41\09-83;)-2-pyrimidine amine;4-(3-Pyridyl)-2-pyrimidinamine;Nilotinib 3-Pyridinyl Impurity;4-(3-Pyridyl)-2-pyrimidineamine;2-Amino-4-(3-pyridyl)pyrimidine;4-(3-PYRIDINYL)-2-PYRIMIDINAMINE;4-(3-Pyridinyl)-2-aminopyrimidine;2-PyriMidinaMine,4-(3-pyridinyl)-
CBNumber: CB8228031
Molecular Formula: C9H8N4
Formula Weight: 172.19
MOL File: 66521-66-2.mol

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4-(Pyridin-3-yl)pyrimidin-2-amine Property

Melting point:: 189-191 °C
Boiling point:: 439.9±37.0 °C(Predicted)
Density: 1.259±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 2.76±0.10(Predicted)
color: Off-White to Pale Yellow
InChI: InChI=1S/C9H8N4/c10-9-12-5-3-8(13-9)7-2-1-4-11-6-7/h1-6H,(H2,10,12,13)
InChIKey: LQHQKYWYKPLKCH-UHFFFAOYSA-N
SMILES: C1(N)=NC=CC(C2=CC=CN=C2)=N1

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Safety

Hazard Codes: T
Risk Statements: 25-20/21/22
Safety Statements: 45-36/37
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: P2666
Product name: 4-(Pyridin-3-yl)pyrimidin-2-amine
Packaging: 1G
Price: $87
Updated: 2024/03/01

TCI Chemical

Product number: P2666
Product name: 4-(Pyridin-3-yl)pyrimidin-2-amine
Packaging: 5G
Price: $303
Updated: 2024/03/01

TRC

Product number: P991700
Product name: 4-(3-Pyridinyl)-2-pyrimidinamine
Packaging: 500mg
Price: $525
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-1-1J
Product name: 4-(Pyridin-3-yl)pyrimidin-2-amine
Packaging: 25g
Price: $592
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 61465
Product name: 4-(3-Pyridinyl)-2-pyrimidinamine
Packaging: 100mg
Price: $620
Updated: 2021/12/16

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4-(Pyridin-3-yl)pyrimidin-2-amine Chemical Properties,Usage,Production

Chemical Properties

White to off-white or brown solid.

Uses

4-(3-Pyridinyl)-2-pyrimidinamine serves as an intermediate compound during the synthesis of Nilotinib. Nilotinib is a selective tyrosine kinase receptor inhibitor used in the therapy of chronic myelogenous leukemia.

Synthesis

3-(Dimethylamino)-1-(pyridine-3-yl) prop-2-en-1-one (15.4 g, 0.088 mol), guanidine nitrate (10.7 g, 0.088 mol), and sodium hydroxide (3.5 g, 0.088 mol) were dissolved in n-butanol (120 mL). The mixture was heated to reflux with stirring and maintained for 16 hours. The reaction mixture was then cooled to room temperature. The solid was collected and washed with water (400 mL). The desired product was dried under vacuum for three days, and 12.7 g of yellow crystals of 4-(Pyridin-3-yl)pyrimidin-2-amine was obtained (yield: 85 %).

4-(Pyridin-3-yl)pyrimidin-2-amine Preparation Products And Raw materials

Raw materials

Ethanol N,N-Dimethylformamide Sodium N,N-Dimethylformamide dimethyl acetal 3-Acetylpyridine

Preparation Products

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4-(Pyridin-3-yl)pyrimidin-2-amine Suppliers

Canada 1 China 142 India 7 Japan 1 United Kingdom 4 United States 18 Global 173

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View Lastest Price from 4-(Pyridin-3-yl)pyrimidin-2-amine manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 4-(Pyridin-3-yl)pyrimidin-2-amine 66521-66-2
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-11-13

WUHAN FORTUNA CHEMICAL CO., LTD

Product: 4-(3-Pyridinyl)-2-aminopyrimidine 66521-66-2
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%min
Supply Ability: 1000kg
Release date: 2021-11-20

Dideu Industries Group Limited

Product: 4-(3-Pyridinyl)-2-aminopyrimidine 66521-66-2
Price: US $1.10/g
Min. Order: 1g
Purity: 99.00%
Supply Ability: 100 Tons Min
Release date: 2021-12-10

66521-66-2, 4-(Pyridin-3-yl)pyrimidin-2-amineRelated Search:

2-Aminopyrimidine 3-Aminopyridine Molasses 2-Aminopyridine 4-Dimethylaminopyridine Nilotinib N-Oxide Nilotinib Impurity 4 Benzenamine, 3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)- Nilotinib 3-(5-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)benzenaMine 3-Iodo-4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl]benzamide 3-(2,4-dimethyl-1H-imidazol-1-yl)-5-(trifluoromethyl)-Benzenamine N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidineamine N-(2-Methyl-5-nitrophenyl)-4-(pyridin-3-yl)pyrimidin-2-amine Imatinib N-Desmethyl Imatinib 2-METHYL-N1-[4-(3-PYRIDINYL)-2-PYRIMIDINYL]-1,4-BENZENEDIAMINE 4-METHYL-6-PYRIDIN-3-YLPYRIMIDIN-2-AMINE

BUTTPARK 41\09-83

4-(3-PYRIDINYL)-2-PYRIMIDINAMINE

4-(3-PYRIDINYL)-2-PYRIMIDINE AMINE

4-(3-PYRIDINYL)-2-PYRIMIDINYLAMINE

4-(PYRIDIN-3-YL)PYRIMIDIN-2-AMINE

4-(3-Pyridyl)-2-pyrimidinamine

4-(3-Pyridinyl)-2-aminopyrimidine

4-(3-Pyridyl)-2-pyrimidineamine

4-(3-Pyridinyl)-2-pyrimidine amine ,97%

2-amino-4-(3-pyridinyl)-pyrimidine

4-Pyridin-3-yl-pyriMidin-2-ylaMine

2-PyriMidinaMine,4-(3-pyridinyl)-

2-Amino-4-(3-pyridyl)pyrimidine

4-(3-piridinyl)-2-pirimidine amine

4-(3-Pyridinyl)-2-pyrimidine amine, 97%, reagent grade

)-2-pyrimidine amine

Nilotinib 3-Pyridinyl Impurity

4-(3-Pyridinyl)-2-aminopyrimidine ISO 9001：2015 REACH

4-(3-Pyridinyl)-2-aminopyrimidineQ: What is 4-(3-Pyridinyl)-2-aminopyrimidine Q: What is the CAS Number of 4-(3-Pyridinyl)-2-aminopyrimidine Q: What is the storage condition of 4-(3-Pyridinyl)-2-aminopyrimidine Q: What are the applications of 4-(3-Pyridinyl)-2-aminopyrimidine

66521-66-2

C9H8N4

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals